Helicobacter spp. and gastric lesions association in minipigs
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência Rural |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300451 |
Resumo: | ABSTRACT: Due to their similarity to humans, studies regarding gastric ulcers in pigs have become of great interest. It is known that Helicobacter spp. is related to the occurrence of these ulcers, as they possess a high prevalence in pigs. This study aimed to associate gastric lesions findings naturally occurring in minipigs related to or not related to the presence of Helicobacter spp., through the ultra-rapid urease test and immunohistochemical analysis, reaffirming the disease in swine as a natural biomedical model for human cases. For this, samples of formalin-fixed paraffin-embedded gastric tissues from 40 minipigs were obtained at the Laboratório de Morfologia e Patologia Animal (LMPA) in the Universidade Estadual do Norte Fluminense (UENF). Regarding the ultra-rapid urease test, no animal was positive in all regions. However, 18 were positive in at least one: six (15%) were positive in the aglandular region, eight (20%) in the antrum region, 13 (32.5%) in the region of the cardiac gland, and one (2.5%) in the region of the fundic gland. Regarding immunohistochemical analysis, only one animal was positive in all regions, and 32 animals were positive in at least one: four (10%) were positive in the aglandular region, 10 (25%) in the antrum region, 23 (57.5%) in the region of the cardiac gland, and three (7.5%) in the region of the fundic gland. The gastric lesion findings showed a close relationship with Helicobacter spp., enriching the laboratory animal pathologies list. The immunostaining of the bacteria not associated with gastric lesions in certain regions demonstrated the saprophytic and opportunisitic nature of Helicobacter. |
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Helicobacter spp. and gastric lesions association in minipigsgastric ulcerHelicobacterimmunohistochemistryswineultrarapid urease testABSTRACT: Due to their similarity to humans, studies regarding gastric ulcers in pigs have become of great interest. It is known that Helicobacter spp. is related to the occurrence of these ulcers, as they possess a high prevalence in pigs. This study aimed to associate gastric lesions findings naturally occurring in minipigs related to or not related to the presence of Helicobacter spp., through the ultra-rapid urease test and immunohistochemical analysis, reaffirming the disease in swine as a natural biomedical model for human cases. For this, samples of formalin-fixed paraffin-embedded gastric tissues from 40 minipigs were obtained at the Laboratório de Morfologia e Patologia Animal (LMPA) in the Universidade Estadual do Norte Fluminense (UENF). Regarding the ultra-rapid urease test, no animal was positive in all regions. However, 18 were positive in at least one: six (15%) were positive in the aglandular region, eight (20%) in the antrum region, 13 (32.5%) in the region of the cardiac gland, and one (2.5%) in the region of the fundic gland. Regarding immunohistochemical analysis, only one animal was positive in all regions, and 32 animals were positive in at least one: four (10%) were positive in the aglandular region, 10 (25%) in the antrum region, 23 (57.5%) in the region of the cardiac gland, and three (7.5%) in the region of the fundic gland. The gastric lesion findings showed a close relationship with Helicobacter spp., enriching the laboratory animal pathologies list. The immunostaining of the bacteria not associated with gastric lesions in certain regions demonstrated the saprophytic and opportunisitic nature of Helicobacter.Universidade Federal de Santa Maria2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300451Ciência Rural v.51 n.3 2021reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20200385info:eu-repo/semantics/openAccessSilveira,Renato LuizCruz,Ana Claudia de MenezesLeandro,Hassan JerdyPetronilha,Mariah Bianchi Reis GusmãoRodrigues,Rachel Bittencourt RibeiroSilva,Maria Aparecida daMedina,Raphael MansurKnackfuss,Fabiana BatalhaCarvalho,Eulógio Carlos Queiroz deeng2021-01-27T00:00:00ZRevista |
dc.title.none.fl_str_mv |
Helicobacter spp. and gastric lesions association in minipigs |
title |
Helicobacter spp. and gastric lesions association in minipigs |
spellingShingle |
Helicobacter spp. and gastric lesions association in minipigs Silveira,Renato Luiz gastric ulcer Helicobacter immunohistochemistry swine ultrarapid urease test |
title_short |
Helicobacter spp. and gastric lesions association in minipigs |
title_full |
Helicobacter spp. and gastric lesions association in minipigs |
title_fullStr |
Helicobacter spp. and gastric lesions association in minipigs |
title_full_unstemmed |
Helicobacter spp. and gastric lesions association in minipigs |
title_sort |
Helicobacter spp. and gastric lesions association in minipigs |
author |
Silveira,Renato Luiz |
author_facet |
Silveira,Renato Luiz Cruz,Ana Claudia de Menezes Leandro,Hassan Jerdy Petronilha,Mariah Bianchi Reis Gusmão Rodrigues,Rachel Bittencourt Ribeiro Silva,Maria Aparecida da Medina,Raphael Mansur Knackfuss,Fabiana Batalha Carvalho,Eulógio Carlos Queiroz de |
author_role |
author |
author2 |
Cruz,Ana Claudia de Menezes Leandro,Hassan Jerdy Petronilha,Mariah Bianchi Reis Gusmão Rodrigues,Rachel Bittencourt Ribeiro Silva,Maria Aparecida da Medina,Raphael Mansur Knackfuss,Fabiana Batalha Carvalho,Eulógio Carlos Queiroz de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Silveira,Renato Luiz Cruz,Ana Claudia de Menezes Leandro,Hassan Jerdy Petronilha,Mariah Bianchi Reis Gusmão Rodrigues,Rachel Bittencourt Ribeiro Silva,Maria Aparecida da Medina,Raphael Mansur Knackfuss,Fabiana Batalha Carvalho,Eulógio Carlos Queiroz de |
dc.subject.por.fl_str_mv |
gastric ulcer Helicobacter immunohistochemistry swine ultrarapid urease test |
topic |
gastric ulcer Helicobacter immunohistochemistry swine ultrarapid urease test |
description |
ABSTRACT: Due to their similarity to humans, studies regarding gastric ulcers in pigs have become of great interest. It is known that Helicobacter spp. is related to the occurrence of these ulcers, as they possess a high prevalence in pigs. This study aimed to associate gastric lesions findings naturally occurring in minipigs related to or not related to the presence of Helicobacter spp., through the ultra-rapid urease test and immunohistochemical analysis, reaffirming the disease in swine as a natural biomedical model for human cases. For this, samples of formalin-fixed paraffin-embedded gastric tissues from 40 minipigs were obtained at the Laboratório de Morfologia e Patologia Animal (LMPA) in the Universidade Estadual do Norte Fluminense (UENF). Regarding the ultra-rapid urease test, no animal was positive in all regions. However, 18 were positive in at least one: six (15%) were positive in the aglandular region, eight (20%) in the antrum region, 13 (32.5%) in the region of the cardiac gland, and one (2.5%) in the region of the fundic gland. Regarding immunohistochemical analysis, only one animal was positive in all regions, and 32 animals were positive in at least one: four (10%) were positive in the aglandular region, 10 (25%) in the antrum region, 23 (57.5%) in the region of the cardiac gland, and three (7.5%) in the region of the fundic gland. The gastric lesion findings showed a close relationship with Helicobacter spp., enriching the laboratory animal pathologies list. The immunostaining of the bacteria not associated with gastric lesions in certain regions demonstrated the saprophytic and opportunisitic nature of Helicobacter. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300451 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782021000300451 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-8478cr20200385 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
Ciência Rural v.51 n.3 2021 reponame:Ciência Rural instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Ciência Rural |
collection |
Ciência Rural |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1749140555651088384 |