Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos

Detalhes bibliográficos
Autor(a) principal: Silva, Aleksandro Schafer da
Data de Publicação: 2009
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações do UFSM
Texto Completo: http://repositorio.ufsm.br/handle/1/27310
Resumo: Changes in blood, plasma and brain cholinesterase activities in Trypanosoma evansi infected cats were investigated. Seven animals were infected with 108 trypomastigote forms each and six were used as control. Animals were monitored for 56 days by examining daily blood smears. The evolution of the disease was monitored by performing hematocrit measurements the day 0, 7, 21, 35 and 49. Blood samples were collected at days 28 and 56 post-inoculation to determine the activity of acetylcholinesterase (AChE) in blood and the activity of butyrylcholinesterase (BChE) in plasma. AChE was also evaluated in brain. A decrease in hematocrit values was observed in the T. evansi infected cats after day 7 (P < 0.05). The activity of AChE in blood and brain, and the activity of BChE in plasma significantly reduced in the infected cats. Therefore, the infection by T. evansi influenced cholinesterases of felines indicating changes in the responses of the cholinergic system.
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spelling 2022-12-13T11:35:13Z2022-12-13T11:35:13Z2009-08-07http://repositorio.ufsm.br/handle/1/27310Changes in blood, plasma and brain cholinesterase activities in Trypanosoma evansi infected cats were investigated. Seven animals were infected with 108 trypomastigote forms each and six were used as control. Animals were monitored for 56 days by examining daily blood smears. The evolution of the disease was monitored by performing hematocrit measurements the day 0, 7, 21, 35 and 49. Blood samples were collected at days 28 and 56 post-inoculation to determine the activity of acetylcholinesterase (AChE) in blood and the activity of butyrylcholinesterase (BChE) in plasma. AChE was also evaluated in brain. A decrease in hematocrit values was observed in the T. evansi infected cats after day 7 (P < 0.05). The activity of AChE in blood and brain, and the activity of BChE in plasma significantly reduced in the infected cats. Therefore, the infection by T. evansi influenced cholinesterases of felines indicating changes in the responses of the cholinergic system.Este estudo objetivou avaliar a atividade das colinesterases no sangue, plasma e cérebro de gatos infectados com Trypanosoma evansi. Sete animais foram infectados com 108 formas tripomastigotas cada um e seis foram utilizados como controle. Os animais foram monitorados por 56 dias, examinando diariamente o esfregaço sanguíneo. A evolução da doença foi controlada por hematócrito realizado nos dia 0, 7, 21, 35 e 49. As amostras de sangue foram coletadas nos dias 28 e 56 pós-inoculação (PI) para determinar a atividade da acetilcolinesterase (AChE) no sangue e da atividade da butirilcolinesterase (BChE) no plasma. AChE também foi avaliada no cérebro. A redução do hematócrito foi observada a partir do sétimo dia PI nos gatos infectados com T. evansi (P < 0,05). A atividade da AChE no sangue e cérebro e da BChE no plasma estava reduzida significativamente nos gatos infectados. Desta forma, a infecção por T. evansi influencia nas atividades de enzimas do sistema colinérgico de felinos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências RuraisPrograma de Pós-Graduação em Medicina VeterináriaUFSMBrasilMedicina VeterináriaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessTrypanosoma evansiGatoAcetilcolinesteraseButirilcolinesteraseCatAcetylcholinesteraseButyrylcholinesteraseCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAInfluência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatosInfluence of Trypanosoma evansi infection on cholinesterase's blood, plasma and brain in catsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisMonteiro, Silvia Gonzalezhttp://lattes.cnpq.br/3762606653182779Leal, Daniela Bitencourt RosaMazzanti, Cinthia Melazzohttp://lattes.cnpq.br/3485147800868305Silva, Aleksandro Schafer da500500000007600600600600600f658c142-7522-4cd5-a133-f2479652bf315a715c1e-0c79-4f72-a603-9969593b23cc2dbfa8b1-3511-410e-8203-4bb0cf639ac806219c3e-9788-4345-8060-bf224f77f2e3reponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGMV_2009_SILVA_ALEKSANDRO.pdfDIS_PPGMV_2009_SILVA_ALEKSANDRO.pdfDissertação de Mestradoapplication/pdf175970http://repositorio.ufsm.br/bitstream/1/27310/1/DIS_PPGMV_2009_SILVA_ALEKSANDRO.pdf1eb67185d92724a55f72d92bb965c2c8MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/27310/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/27310/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD531/273102022-12-13 08:35:13.488oai:repositorio.ufsm.br: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 Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-12-13T11:35:13Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false
dc.title.por.fl_str_mv Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
dc.title.alternative.eng.fl_str_mv Influence of Trypanosoma evansi infection on cholinesterase's blood, plasma and brain in cats
title Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
spellingShingle Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
Silva, Aleksandro Schafer da
Trypanosoma evansi
Gato
Acetilcolinesterase
Butirilcolinesterase
Cat
Acetylcholinesterase
Butyrylcholinesterase
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
title_short Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
title_full Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
title_fullStr Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
title_full_unstemmed Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
title_sort Influência da infecção por Trypanosoma evansi sobre as colinesterases no sangue, plasma e cérebro de gatos
author Silva, Aleksandro Schafer da
author_facet Silva, Aleksandro Schafer da
author_role author
dc.contributor.advisor1.fl_str_mv Monteiro, Silvia Gonzalez
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/3762606653182779
dc.contributor.referee1.fl_str_mv Leal, Daniela Bitencourt Rosa
dc.contributor.referee2.fl_str_mv Mazzanti, Cinthia Melazzo
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3485147800868305
dc.contributor.author.fl_str_mv Silva, Aleksandro Schafer da
contributor_str_mv Monteiro, Silvia Gonzalez
Leal, Daniela Bitencourt Rosa
Mazzanti, Cinthia Melazzo
dc.subject.por.fl_str_mv Trypanosoma evansi
Gato
Acetilcolinesterase
Butirilcolinesterase
topic Trypanosoma evansi
Gato
Acetilcolinesterase
Butirilcolinesterase
Cat
Acetylcholinesterase
Butyrylcholinesterase
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
dc.subject.eng.fl_str_mv Cat
Acetylcholinesterase
Butyrylcholinesterase
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
description Changes in blood, plasma and brain cholinesterase activities in Trypanosoma evansi infected cats were investigated. Seven animals were infected with 108 trypomastigote forms each and six were used as control. Animals were monitored for 56 days by examining daily blood smears. The evolution of the disease was monitored by performing hematocrit measurements the day 0, 7, 21, 35 and 49. Blood samples were collected at days 28 and 56 post-inoculation to determine the activity of acetylcholinesterase (AChE) in blood and the activity of butyrylcholinesterase (BChE) in plasma. AChE was also evaluated in brain. A decrease in hematocrit values was observed in the T. evansi infected cats after day 7 (P < 0.05). The activity of AChE in blood and brain, and the activity of BChE in plasma significantly reduced in the infected cats. Therefore, the infection by T. evansi influenced cholinesterases of felines indicating changes in the responses of the cholinergic system.
publishDate 2009
dc.date.issued.fl_str_mv 2009-08-07
dc.date.accessioned.fl_str_mv 2022-12-13T11:35:13Z
dc.date.available.fl_str_mv 2022-12-13T11:35:13Z
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dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Rurais
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Medicina Veterinária
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dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Medicina Veterinária
publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Rurais
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