Eficácia da metilxantina no controle da eimeriose em frangos de corte

Detalhes bibliográficos
Autor(a) principal: Shibuya, Fabio Yuji
Data de Publicação: 2023
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações do UFSM
Texto Completo: http://repositorio.ufsm.br/handle/1/28298
Resumo: Coccidiosis is a common disease in poultry industry and the etiology is Eimeria sp. The disease is known for its enteric lesions, reduction of the intestinal epithelium reducing the poultry growthing and increasing mortality. The poultry industry is demanding for alternative and natural products in order to treat and/or control avian diseases. Methylxanthine is an alcaloid with stimulant properties and extracted from coffee, tea, chocolate, cocoa tea, guarana or citrus sp. There are several benefits of its use such as the immunomodulatory potential in innate and adaptative immunity like stimulating the production of some cytokines in response to coccidiosis infection. The objective of this study was to evaluate the efficacy of Methylxanthine in the Eimeria acervuline and Eimeria tenella control. Therefore, we compared 60 chicks separated in 3 treatments and maintained for 28 days. Group T (negative control); Group T2 (infected with Eimeria acervuline and Eimeria tenella); and Group T3 (infected with Eimeria acervuline and Eimeria tenella and treated with Methylxanthine dilutes in water (30 ml/L). At 28 days of observation, performance data was obtained and the chicken were euthanized. At the necropsy, intestines and cecum samples were submitted to histopathological analysis. The Mehylxanthine treatment reduced the performance losses and intestinal lesions from Eimeria acervuline and Eimeria tenella as observed in the treated group (T3). The treatment with Methylxantine proved efficacy in the infection control of coccidiosis in broiler.
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spelling 2023-03-20T19:25:42Z2023-03-20T19:25:42Z2023-02-10http://repositorio.ufsm.br/handle/1/28298Coccidiosis is a common disease in poultry industry and the etiology is Eimeria sp. The disease is known for its enteric lesions, reduction of the intestinal epithelium reducing the poultry growthing and increasing mortality. The poultry industry is demanding for alternative and natural products in order to treat and/or control avian diseases. Methylxanthine is an alcaloid with stimulant properties and extracted from coffee, tea, chocolate, cocoa tea, guarana or citrus sp. There are several benefits of its use such as the immunomodulatory potential in innate and adaptative immunity like stimulating the production of some cytokines in response to coccidiosis infection. The objective of this study was to evaluate the efficacy of Methylxanthine in the Eimeria acervuline and Eimeria tenella control. Therefore, we compared 60 chicks separated in 3 treatments and maintained for 28 days. Group T (negative control); Group T2 (infected with Eimeria acervuline and Eimeria tenella); and Group T3 (infected with Eimeria acervuline and Eimeria tenella and treated with Methylxanthine dilutes in water (30 ml/L). At 28 days of observation, performance data was obtained and the chicken were euthanized. At the necropsy, intestines and cecum samples were submitted to histopathological analysis. The Mehylxanthine treatment reduced the performance losses and intestinal lesions from Eimeria acervuline and Eimeria tenella as observed in the treated group (T3). The treatment with Methylxantine proved efficacy in the infection control of coccidiosis in broiler.A coccidiose é uma doença de alta incidência na avicultura comercial. É causada pelo protozoário Eimeria sp., caracterizada por quadro entérico, lesão de mucosa intestinal dos frangos, diminuição do desenvolvimento, inclusive podendo causar a morte das aves, e o seu controle é ainda um desafio para a avicultura. Na procura por alternativas terapêuticas para a coccidiose, são utilizados produtos naturais como a metilxantina, um alcaloide com efeitos estimulantes encontrada no café, chá, cacau, guaraná e erva-mate. Dentre seus benefícios estão a capacidade de modular a imunidade inata e adaptativa, inclusive, estimulando a produção das citocinas, que são reativas a coccidiose. O objetivo deste estudo foi mensurar a eficácia da metilxantina no controle da coccidiose, em frangos de corte infectados por Eimeria acervulina e Eimeria tenella. Para tanto, realizou-se um estudo com 60 pintos de um dia de idade, mantidos por 28 dias, dispostos em 3 tratamentos: T1: controle negativo; T2: desafio via oral com Eimeria acervulina e Eimeria tenella; e T3: desafio via oral com Eimeria acervulina e Eimeria tenella e tratados com solução diluída (0,0105 g/L diluída em água a 30 ml/L) de metilxantina. Dados de ganho de peso foram coletados com 28 dias de idade, assim como abate e suas necropsias, onde foram separadas amostras de intestino e ceco para exame histopatológico. Os animais do T1 e T3, ao contrário do T2, apresentaram pesos estatisticamente similares para 95% de confiança (α = 0,05) e não foram observadas lesões características de coccidiose e oocistos em suas alças intestinais e cecos. O T2 apresentou inflamação em sua mucosa, presença de protozoários compatíveis com Eimeria acervulina e perda significativa de performance no peso dos animais aos 28 dias. Desta forma, o tratamento com metilxantina se mostrou eficaz no controle dos sinais clínicos e lesões de Eimeria acervulina e Eimeria tenella.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESporUniversidade Federal de Santa MariaCentro de Ciências RuraisPrograma de Pós-Graduação em Medicina VeterináriaUFSMBrasilMedicina VeterináriaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessEimeria acervulinaEimeria tenellaCoccidioseMetilxantinaFrangos de corteCoccidiosisMethylxanthineBroilerCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAEficácia da metilxantina no controle da eimeriose em frangos de corteEffect of methylxanthine against coccidiosis in broilerinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisSantos, Helton Fernandes doshttp://lattes.cnpq.br/6201699995834067Lovato, MaristelaDilkin, Paulohttp://lattes.cnpq.br/2241377032063464Shibuya, Fabio Yuji50050000000760060060060060053e185d4-d01c-4f73-ac01-5c2a868afd0db527cf75-903d-4fab-abee-69a241cfd7ea2d5fc944-35a9-4304-a1ab-286538ac9c432d36f22e-512c-444f-ab39-bd1f19826f02reponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALDIS_PPGMV_2023_SHIBUYA_FABIO.pdfDIS_PPGMV_2023_SHIBUYA_FABIO.pdfDissertação de Mestradoapplication/pdf1536427http://repositorio.ufsm.br/bitstream/1/28298/1/DIS_PPGMV_2023_SHIBUYA_FABIO.pdf8561c22c8505a577525f53b8043c785fMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81956http://repositorio.ufsm.br/bitstream/1/28298/3/license.txt2f0571ecee68693bd5cd3f17c1e075dfMD53CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.ufsm.br/bitstream/1/28298/2/license_rdf4460e5956bc1d1639be9ae6146a50347MD521/282982023-03-20 16:25:42.288oai:repositorio.ufsm.br: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 Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-03-20T19:25:42Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false
dc.title.por.fl_str_mv Eficácia da metilxantina no controle da eimeriose em frangos de corte
dc.title.alternative.eng.fl_str_mv Effect of methylxanthine against coccidiosis in broiler
title Eficácia da metilxantina no controle da eimeriose em frangos de corte
spellingShingle Eficácia da metilxantina no controle da eimeriose em frangos de corte
Shibuya, Fabio Yuji
Eimeria acervulina
Eimeria tenella
Coccidiose
Metilxantina
Frangos de corte
Coccidiosis
Methylxanthine
Broiler
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
title_short Eficácia da metilxantina no controle da eimeriose em frangos de corte
title_full Eficácia da metilxantina no controle da eimeriose em frangos de corte
title_fullStr Eficácia da metilxantina no controle da eimeriose em frangos de corte
title_full_unstemmed Eficácia da metilxantina no controle da eimeriose em frangos de corte
title_sort Eficácia da metilxantina no controle da eimeriose em frangos de corte
author Shibuya, Fabio Yuji
author_facet Shibuya, Fabio Yuji
author_role author
dc.contributor.advisor1.fl_str_mv Santos, Helton Fernandes dos
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/6201699995834067
dc.contributor.referee1.fl_str_mv Lovato, Maristela
dc.contributor.referee2.fl_str_mv Dilkin, Paulo
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/2241377032063464
dc.contributor.author.fl_str_mv Shibuya, Fabio Yuji
contributor_str_mv Santos, Helton Fernandes dos
Lovato, Maristela
Dilkin, Paulo
dc.subject.por.fl_str_mv Eimeria acervulina
Eimeria tenella
Coccidiose
Metilxantina
Frangos de corte
topic Eimeria acervulina
Eimeria tenella
Coccidiose
Metilxantina
Frangos de corte
Coccidiosis
Methylxanthine
Broiler
CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
dc.subject.eng.fl_str_mv Coccidiosis
Methylxanthine
Broiler
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA
description Coccidiosis is a common disease in poultry industry and the etiology is Eimeria sp. The disease is known for its enteric lesions, reduction of the intestinal epithelium reducing the poultry growthing and increasing mortality. The poultry industry is demanding for alternative and natural products in order to treat and/or control avian diseases. Methylxanthine is an alcaloid with stimulant properties and extracted from coffee, tea, chocolate, cocoa tea, guarana or citrus sp. There are several benefits of its use such as the immunomodulatory potential in innate and adaptative immunity like stimulating the production of some cytokines in response to coccidiosis infection. The objective of this study was to evaluate the efficacy of Methylxanthine in the Eimeria acervuline and Eimeria tenella control. Therefore, we compared 60 chicks separated in 3 treatments and maintained for 28 days. Group T (negative control); Group T2 (infected with Eimeria acervuline and Eimeria tenella); and Group T3 (infected with Eimeria acervuline and Eimeria tenella and treated with Methylxanthine dilutes in water (30 ml/L). At 28 days of observation, performance data was obtained and the chicken were euthanized. At the necropsy, intestines and cecum samples were submitted to histopathological analysis. The Mehylxanthine treatment reduced the performance losses and intestinal lesions from Eimeria acervuline and Eimeria tenella as observed in the treated group (T3). The treatment with Methylxantine proved efficacy in the infection control of coccidiosis in broiler.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-03-20T19:25:42Z
dc.date.available.fl_str_mv 2023-03-20T19:25:42Z
dc.date.issued.fl_str_mv 2023-02-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Rurais
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Medicina Veterinária
dc.publisher.initials.fl_str_mv UFSM
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Medicina Veterinária
publisher.none.fl_str_mv Universidade Federal de Santa Maria
Centro de Ciências Rurais
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