Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/11196 |
Resumo: | In last years, selenium organic compounds of selenium have been targets of interest in organic synthesis because of their synthetic application and their pharmacological properties. Diphenyl diselenide (PhSe)2 is an organic compound of selenium that has several pharmacological effects; however the poor water-solubility and low oral bioavailability can be a limit for its clinical utility. Polymeric nanoparticles has been an impotant model to carry drugs with advantages such as increase bioavailability, targeting to specific sites and the possibility of encapsulation of lipophilic compounds quite efficiently. In view of the quest for developing a system to control drug release and improve its oral bioavailability, this study aims to prepare nanospheres and nanocapsules of (PhSe)2 by the interfacial deposition method of preformed polymer cores using different oils (miglyol, canola oil and omega-3) as the oil core. The nanocapsules will be characterized by measuring the pH, mean particle size, polydispersity index, zeta potential, rate of association and determination of (PhSe)2. By adjusting the process parameters, the results of the optimized formulation showed a size distribution with a polydispersity index of up to 0.2, an average diameter of less than 330 nm, zeta potential was greater at -16 mV, and encapsulation rate efficiency of 99.9 % found for all formulations developed. The biological tests performed in mice with the nanocapsules of (PhSe)2 containing canola oil as the oil core, showed increased bioavailability of the (PhSe)2 compared with the (PhSe)2 free, showing a proeminent influence of nanoparticle systems for biological properties of organochalcogenium compounds. |
id |
UFSM_d803a8097543a5f0d2d5109e9a993367 |
---|---|
oai_identifier_str |
oai:repositorio.ufsm.br:1/11196 |
network_acronym_str |
UFSM |
network_name_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
repository_id_str |
|
spelling |
2013-01-312013-01-312012-03-30ALVES, Camila Ferrazza. DIPHENYL DISELENIDE NANOCAPSULES AND NANOSPHERES: SYNTHESIS AND BIOLOGICAL DITRIBUTION. 2012. 127 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Santa Maria, Santa Maria, 2012.http://repositorio.ufsm.br/handle/1/11196In last years, selenium organic compounds of selenium have been targets of interest in organic synthesis because of their synthetic application and their pharmacological properties. Diphenyl diselenide (PhSe)2 is an organic compound of selenium that has several pharmacological effects; however the poor water-solubility and low oral bioavailability can be a limit for its clinical utility. Polymeric nanoparticles has been an impotant model to carry drugs with advantages such as increase bioavailability, targeting to specific sites and the possibility of encapsulation of lipophilic compounds quite efficiently. In view of the quest for developing a system to control drug release and improve its oral bioavailability, this study aims to prepare nanospheres and nanocapsules of (PhSe)2 by the interfacial deposition method of preformed polymer cores using different oils (miglyol, canola oil and omega-3) as the oil core. The nanocapsules will be characterized by measuring the pH, mean particle size, polydispersity index, zeta potential, rate of association and determination of (PhSe)2. By adjusting the process parameters, the results of the optimized formulation showed a size distribution with a polydispersity index of up to 0.2, an average diameter of less than 330 nm, zeta potential was greater at -16 mV, and encapsulation rate efficiency of 99.9 % found for all formulations developed. The biological tests performed in mice with the nanocapsules of (PhSe)2 containing canola oil as the oil core, showed increased bioavailability of the (PhSe)2 compared with the (PhSe)2 free, showing a proeminent influence of nanoparticle systems for biological properties of organochalcogenium compounds.Nos últimos anos, os compostos orgânicos de selênio têm sido alvos de interesse em síntese orgânica em virtude da descoberta de suas aplicações sintéticas e de suas propriedades farmacológicas. O disseleneto de difenila (PhSe)2 é um composto orgânico de selênio que apresenta diversos efeitos farmacológicos descritos, porém a pouca solubilidade em água e baixa biodisponibilidade oral podem ser um limite para seu uso clínico. Nanopartículas poliméricas vem sendo um importante modelo para o carreamento de fármacos, apresentando vantagens como maior biodisponibilidade, direcionamento a sítios específicos e possibilidade de encapsulamento de compostos lipofílicos de maneira bastante eficiente. Tendo em vista a busca pelo desenvolvimento de um sistema de controle da liberação de fármacos, este trabalho teve como objetivo preparar nanoesferas e nanocápsulas de (PhSe)2 através do método de deposição interfacial do polímero pré-formado utilizando diferentes óleos (miglyol, óleo de canola e ômega-3) como como núcleo oleoso. As nanocápsulas foram caracterizadas através da medida do pH, tamanho médio de partícula, índice de polidispersão, potencial zeta, taxa de associação e doseamento do (PhSe)2. Os resultados das formulações desenvolvidas apresentaram uma distribuição do tamanho de partícula com um índice de polidispersão de até 0,2; diâmetro médio inferior a 330 nm; o potencial zeta foi superior a -16 mV, onde a taxa de encapsulamento encontrada foi de 99,9% para todas as formulações desenvolvidas. Os ensaios biológicos feitos em camundongos com as nanocápsulas de (PhSe)2 contendo óleo de canola como núcleo oleoso mostraram maior biodisponibilidade das nanocápsulas de (PhSe)2 em comparação com o (PhSe)2 livre, mostrando uma proeminente influencia dos sistemas nanoparticulados nas propriedades biológicas de compostos organocalcogênio.Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorapplication/pdfporUniversidade Federal de Santa MariaPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica ToxicológicaUFSMBRBioquímicaDisseleneto de difenilaNanocápsulaNanoesferaExcreçãoDistribuiçãoDiphenyl diselenideNanocapsulesNanospheresExcretionDistributionCNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICANanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológicaDiphenyl diselenide nanocapsules and nanospheres: synthesis and biological ditributioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisRodrigues, Oscar Endrigo Dorneleshttp://lattes.cnpq.br/6536519955416085Luchese, Cristianehttp://lattes.cnpq.br/3420684025232526Dornelles, Lucianohttp://lattes.cnpq.br/7629319262073140http://lattes.cnpq.br/9399465304106331Alves, Camila Ferrazza20080000000240050030050050009fef019-ac43-4d8b-83d3-3565e4686d7b52c99926-a40a-4a85-85c3-454e9e236d186394c49e-1d1b-44ff-89fb-e3d4c9a0f1314a671e0c-bfb0-436b-bd8f-ab5645f4229einfo:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações do UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSMORIGINALALVES, CAMILA FERRAZZA.pdfapplication/pdf3953268http://repositorio.ufsm.br/bitstream/1/11196/1/ALVES%2c%20CAMILA%20FERRAZZA.pdf852265afda67252b4edd4c4eae058a7aMD51TEXTALVES, CAMILA FERRAZZA.pdf.txtALVES, CAMILA FERRAZZA.pdf.txtExtracted texttext/plain144619http://repositorio.ufsm.br/bitstream/1/11196/2/ALVES%2c%20CAMILA%20FERRAZZA.pdf.txt8a0027efaf0ec215543b8d7a023212ebMD52THUMBNAILALVES, CAMILA FERRAZZA.pdf.jpgALVES, CAMILA FERRAZZA.pdf.jpgIM Thumbnailimage/jpeg5041http://repositorio.ufsm.br/bitstream/1/11196/3/ALVES%2c%20CAMILA%20FERRAZZA.pdf.jpg046c7d7c77024ea6f8df7348a18ccd17MD531/111962022-06-28 08:37:35.33oai:repositorio.ufsm.br:1/11196Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2022-06-28T11:37:35Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.por.fl_str_mv |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica |
dc.title.alternative.eng.fl_str_mv |
Diphenyl diselenide nanocapsules and nanospheres: synthesis and biological ditribution |
title |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica |
spellingShingle |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica Alves, Camila Ferrazza Disseleneto de difenila Nanocápsula Nanoesfera Excreção Distribuição Diphenyl diselenide Nanocapsules Nanospheres Excretion Distribution CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
title_short |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica |
title_full |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica |
title_fullStr |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica |
title_full_unstemmed |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica |
title_sort |
Nanocápsulas e nanoesferas de disseleneto de difenila: síntese e distribuição biológica |
author |
Alves, Camila Ferrazza |
author_facet |
Alves, Camila Ferrazza |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Rodrigues, Oscar Endrigo Dorneles |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6536519955416085 |
dc.contributor.referee1.fl_str_mv |
Luchese, Cristiane |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/3420684025232526 |
dc.contributor.referee2.fl_str_mv |
Dornelles, Luciano |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/7629319262073140 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/9399465304106331 |
dc.contributor.author.fl_str_mv |
Alves, Camila Ferrazza |
contributor_str_mv |
Rodrigues, Oscar Endrigo Dorneles Luchese, Cristiane Dornelles, Luciano |
dc.subject.por.fl_str_mv |
Disseleneto de difenila Nanocápsula Nanoesfera Excreção Distribuição Diphenyl diselenide Nanocapsules Nanospheres Excretion Distribution |
topic |
Disseleneto de difenila Nanocápsula Nanoesfera Excreção Distribuição Diphenyl diselenide Nanocapsules Nanospheres Excretion Distribution CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
dc.subject.cnpq.fl_str_mv |
CNPQ::CIENCIAS BIOLOGICAS::BIOQUIMICA |
description |
In last years, selenium organic compounds of selenium have been targets of interest in organic synthesis because of their synthetic application and their pharmacological properties. Diphenyl diselenide (PhSe)2 is an organic compound of selenium that has several pharmacological effects; however the poor water-solubility and low oral bioavailability can be a limit for its clinical utility. Polymeric nanoparticles has been an impotant model to carry drugs with advantages such as increase bioavailability, targeting to specific sites and the possibility of encapsulation of lipophilic compounds quite efficiently. In view of the quest for developing a system to control drug release and improve its oral bioavailability, this study aims to prepare nanospheres and nanocapsules of (PhSe)2 by the interfacial deposition method of preformed polymer cores using different oils (miglyol, canola oil and omega-3) as the oil core. The nanocapsules will be characterized by measuring the pH, mean particle size, polydispersity index, zeta potential, rate of association and determination of (PhSe)2. By adjusting the process parameters, the results of the optimized formulation showed a size distribution with a polydispersity index of up to 0.2, an average diameter of less than 330 nm, zeta potential was greater at -16 mV, and encapsulation rate efficiency of 99.9 % found for all formulations developed. The biological tests performed in mice with the nanocapsules of (PhSe)2 containing canola oil as the oil core, showed increased bioavailability of the (PhSe)2 compared with the (PhSe)2 free, showing a proeminent influence of nanoparticle systems for biological properties of organochalcogenium compounds. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-03-30 |
dc.date.accessioned.fl_str_mv |
2013-01-31 |
dc.date.available.fl_str_mv |
2013-01-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ALVES, Camila Ferrazza. DIPHENYL DISELENIDE NANOCAPSULES AND NANOSPHERES: SYNTHESIS AND BIOLOGICAL DITRIBUTION. 2012. 127 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufsm.br/handle/1/11196 |
identifier_str_mv |
ALVES, Camila Ferrazza. DIPHENYL DISELENIDE NANOCAPSULES AND NANOSPHERES: SYNTHESIS AND BIOLOGICAL DITRIBUTION. 2012. 127 f. Dissertação (Mestrado em Ciências Biológicas) - Universidade Federal de Santa Maria, Santa Maria, 2012. |
url |
http://repositorio.ufsm.br/handle/1/11196 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.cnpq.fl_str_mv |
200800000002 |
dc.relation.confidence.fl_str_mv |
400 500 300 500 500 |
dc.relation.authority.fl_str_mv |
09fef019-ac43-4d8b-83d3-3565e4686d7b 52c99926-a40a-4a85-85c3-454e9e236d18 6394c49e-1d1b-44ff-89fb-e3d4c9a0f131 4a671e0c-bfb0-436b-bd8f-ab5645f4229e |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica |
dc.publisher.initials.fl_str_mv |
UFSM |
dc.publisher.country.fl_str_mv |
BR |
dc.publisher.department.fl_str_mv |
Bioquímica |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria |
dc.source.none.fl_str_mv |
reponame:Biblioteca Digital de Teses e Dissertações do UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Biblioteca Digital de Teses e Dissertações do UFSM |
collection |
Biblioteca Digital de Teses e Dissertações do UFSM |
bitstream.url.fl_str_mv |
http://repositorio.ufsm.br/bitstream/1/11196/1/ALVES%2c%20CAMILA%20FERRAZZA.pdf http://repositorio.ufsm.br/bitstream/1/11196/2/ALVES%2c%20CAMILA%20FERRAZZA.pdf.txt http://repositorio.ufsm.br/bitstream/1/11196/3/ALVES%2c%20CAMILA%20FERRAZZA.pdf.jpg |
bitstream.checksum.fl_str_mv |
852265afda67252b4edd4c4eae058a7a 8a0027efaf0ec215543b8d7a023212eb 046c7d7c77024ea6f8df7348a18ccd17 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Biblioteca Digital de Teses e Dissertações do UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1791086294378479616 |