Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/34537 http://dx.doi.org/10.1371/journal.pone.0030292 |
Resumo: | Introduction: Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.Methods: A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. the HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/mu L.Results: Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4,350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4.350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4.350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.Conclusions: Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions. |
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Sucupira, Maria Cecilia Araripe [UNIFESP]Sanabani, SabriCortes, Rodrigo M. [UNIFESP]Giret, Maria Teresa MaidanaTomiyama, Helena [UNIFESP]Sauer, Mariana M. [UNIFESP]Sabino, Ester CerdeiraJanini, Luiz Mario [UNIFESP]Kallas, Esper Georges [UNIFESP]Diaz, Ricardo Sobhie [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Fundacao Pro SangueUniversidade de São Paulo (USP)2016-01-24T14:17:49Z2016-01-24T14:17:49Z2012-01-26Plos One. San Francisco: Public Library Science, v. 7, n. 1, 9 p., 2012.1932-6203http://repositorio.unifesp.br/handle/11600/34537http://dx.doi.org/10.1371/journal.pone.0030292WOS000301703800012.pdf10.1371/journal.pone.0030292WOS:000301703800012Introduction: Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.Methods: A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. the HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/mu L.Results: Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4,350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4.350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4.350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.Conclusions: Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions.Brazilian Program for STD and AIDSMinistry of HealthSão Paulo City Health DepartmentFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Brazilian Ministry of EducationUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilFundacao Pro Sangue, São Paulo Blood Bank, São Paulo, BrazilUniv São Paulo, Div Clin Immunol & Allergy, São Paulo, BrazilUniv São Paulo, Div Infect Dis, São Paulo, BrazilUniversidade Federal de São Paulo, Div Microbiol, São Paulo, BrazilUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilUniversidade Federal de São Paulo, Div Microbiol, São Paulo, BrazilMinistry of Health: 914/BRA/3014-UNESCO/KallasSão Paulo City Health Department: 2004-0.168.922-7/KallasFAPESP: 04/15856-9/DiazWeb of Science9engPublic Library SciencePlos OneFaster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000301703800012.pdfapplication/pdf356168${dspace.ui.url}/bitstream/11600/34537/1/WOS000301703800012.pdf1a41799c94f789168092de663e616c30MD51open accessTEXTWOS000301703800012.pdf.txtWOS000301703800012.pdf.txtExtracted texttext/plain47678${dspace.ui.url}/bitstream/11600/34537/2/WOS000301703800012.pdf.txtac1a13e6af7cf7aba8f45c5367368675MD52open access11600/345372023-02-15 10:46:35.611open accessoai:repositorio.unifesp.br:11600/34537Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:17.401885Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains |
title |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains |
spellingShingle |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains Sucupira, Maria Cecilia Araripe [UNIFESP] |
title_short |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains |
title_full |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains |
title_fullStr |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains |
title_full_unstemmed |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains |
title_sort |
Faster HIV-1 Disease Progression among Brazilian Individuals Recently Infected with CXCR4-Utilizing Strains |
author |
Sucupira, Maria Cecilia Araripe [UNIFESP] |
author_facet |
Sucupira, Maria Cecilia Araripe [UNIFESP] Sanabani, Sabri Cortes, Rodrigo M. [UNIFESP] Giret, Maria Teresa Maidana Tomiyama, Helena [UNIFESP] Sauer, Mariana M. [UNIFESP] Sabino, Ester Cerdeira Janini, Luiz Mario [UNIFESP] Kallas, Esper Georges [UNIFESP] Diaz, Ricardo Sobhie [UNIFESP] |
author_role |
author |
author2 |
Sanabani, Sabri Cortes, Rodrigo M. [UNIFESP] Giret, Maria Teresa Maidana Tomiyama, Helena [UNIFESP] Sauer, Mariana M. [UNIFESP] Sabino, Ester Cerdeira Janini, Luiz Mario [UNIFESP] Kallas, Esper Georges [UNIFESP] Diaz, Ricardo Sobhie [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Fundacao Pro Sangue Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Sucupira, Maria Cecilia Araripe [UNIFESP] Sanabani, Sabri Cortes, Rodrigo M. [UNIFESP] Giret, Maria Teresa Maidana Tomiyama, Helena [UNIFESP] Sauer, Mariana M. [UNIFESP] Sabino, Ester Cerdeira Janini, Luiz Mario [UNIFESP] Kallas, Esper Georges [UNIFESP] Diaz, Ricardo Sobhie [UNIFESP] |
description |
Introduction: Primary HIV infection is usually caused by R5 viruses, and there is an association between the emergence of CCXR4-utilizing strains and faster disease progression. We characterized HIV-1 from a cohort of recently infected individuals in Brazil, predicted the virus's co-receptor use based on the env genotype and attempted to correlate virus profiles with disease progression.Methods: A total of 72 recently infected HIV patients were recruited based on the Serologic Testing Algorithm for Recent HIV Seroconversion and were followed every three to four months for up to 78 weeks. the HIV-1 V3 region was characterized by sequencing nine to twelve weeks after enrollment. Disease progression was characterized by CD4+ T-cell count decline to levels consistently below 350 cells/mu L.Results: Twelve out of 72 individuals (17%) were predicted to harbor CXCR4-utilizing strains; a baseline CD4,350 was more frequent among these individuals (p = 0.03). Fifty-seven individuals that were predicted to have CCR5-utilizing viruses and 10 individuals having CXCR4-utilizing strains presented with baseline CD4.350; after 78 weeks, 33 individuals with CCR5 strains and one individual with CXCR4 strains had CD4.350 (p = 0.001). There was no association between CD4 decline and demographic characteristics or HIV-1 subtype.Conclusions: Our findings confirm the presence of strains with higher in vitro pathogenicity during early HIV infection, suggesting that even among recently infected individuals, rapid progression may be a consequence of the early emergence of CXCR4-utilizing strains. Characterizing the HIV-1 V3 region by sequencing may be useful in predicting disease progression and guiding treatment initiation decisions. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-01-26 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:49Z |
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2016-01-24T14:17:49Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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dc.identifier.citation.fl_str_mv |
Plos One. San Francisco: Public Library Science, v. 7, n. 1, 9 p., 2012. |
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http://repositorio.unifesp.br/handle/11600/34537 http://dx.doi.org/10.1371/journal.pone.0030292 |
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1932-6203 |
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WOS000301703800012.pdf |
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10.1371/journal.pone.0030292 |
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Plos One. San Francisco: Public Library Science, v. 7, n. 1, 9 p., 2012. 1932-6203 WOS000301703800012.pdf 10.1371/journal.pone.0030292 WOS:000301703800012 |
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http://repositorio.unifesp.br/handle/11600/34537 http://dx.doi.org/10.1371/journal.pone.0030292 |
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