Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/1980-5373-MR-2016-0467 https://repositorio.unifesp.br/handle/11600/53521 |
Resumo: | Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. beta-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, beta-TCP and beta-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (8688%) and pore sizes ranging from 200 to 500 mu m. Even though alumina did not promote improvement in beta-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, beta-TCP and beta-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
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Siqueira, Lilian [UNIFESP]de Paula, Cynthia Guimaraes [UNIFESP]Motisuke, Mariana [UNIFESP]Gouveia, Rubia FigueredoAfonso Camargo, Samira EstevesMoreira Milhan, Noala VicensotoTriches, Eliandra de Sousa [UNIFESP]2020-06-26T16:30:23Z2020-06-26T16:30:23Z2017http://dx.doi.org/10.1590/1980-5373-MR-2016-0467Materials Research-Ibero-American Journal Of Materials. Sao Carlos, v. 20, n. 4, p. 973-983, 2017.1516-1439https://repositorio.unifesp.br/handle/11600/53521S1516-14392017000400973.pdfS1516-1439201700040097310.1590/1980-5373-MR-2016-0467WOS:000410628100016Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. beta-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, beta-TCP and beta-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (8688%) and pore sizes ranging from 200 to 500 mu m. Even though alumina did not promote improvement in beta-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, beta-TCP and beta-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering.Sao Paulo Research Foundation - FAPESPNational Council for Scientific and Technological DevelopmentNational Council for Scientific and Technological DevelopmentUniv Fed Sao Paulo UNIFESP, Sci & Technol Inst ICT, Bioceram Lab BIOCERAM, 330 Talim St, BR-12231280 Sao Jose Dos Campos, SP, BrazilCNPEM, Brazilian Nanotechnol Natl Lab LNNANO, POB 6192, BR-13083970 Campinas, SP, BrazilUniv Estadual Paulista Julio de Mesquita Filho UN, Sch Dent, Dept Biosci & Oral Diag, 777 Engenheiro Francisco Jose Longo Ave, BR-12245000 Sao Jose Dos Campos, SP, BrazilUniv Fed Sao Paulo UNIFESP, Sci & Technol Inst ICT, Bioceram Lab BIOCERAM, 330 Talim St, BR-12231280 Sao Jose Dos Campos, SP, BrazilFAPESP: 2010/00863-0National Council for Scientific and Technological Development: 456461/2014-0]CNPq/PIBITI/UNIFESPWeb of Science973-983engUniv Fed Sao Carlos, Dept Engenharia MaterialsMaterials Research-Ibero-American Journal Of MaterialsTricalcium phosphatealuminagel-casting methodcytocompatibilityscaffoldsPreparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foamsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Carlos204info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1516-14392017000400973.pdfapplication/pdf3152164${dspace.ui.url}/bitstream/11600/53521/1/S1516-14392017000400973.pdfac31574319513b31f475fc00a2dfc1a2MD51open accessTEXTS1516-14392017000400973.pdf.txtS1516-14392017000400973.pdf.txtExtracted texttext/plain37601${dspace.ui.url}/bitstream/11600/53521/8/S1516-14392017000400973.pdf.txt1c112f354c603f150c238c38bce42c99MD58open accessTHUMBNAILS1516-14392017000400973.pdf.jpgS1516-14392017000400973.pdf.jpgIM Thumbnailimage/jpeg5921${dspace.ui.url}/bitstream/11600/53521/10/S1516-14392017000400973.pdf.jpg8978c6011e5e95238215076197f1ba1bMD510open access11600/535212023-06-05 19:09:53.081open accessoai:repositorio.unifesp.br:11600/53521Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:09:53Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
spellingShingle |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams Siqueira, Lilian [UNIFESP] Tricalcium phosphate alumina gel-casting method cytocompatibility scaffolds |
title_short |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_full |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_fullStr |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_full_unstemmed |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
title_sort |
Preparation, Characterization and Biological Studies of B-TCP and B-TCP/Al2O3 Scaffolds Obtained by Gel-Casting of Foams |
author |
Siqueira, Lilian [UNIFESP] |
author_facet |
Siqueira, Lilian [UNIFESP] de Paula, Cynthia Guimaraes [UNIFESP] Motisuke, Mariana [UNIFESP] Gouveia, Rubia Figueredo Afonso Camargo, Samira Esteves Moreira Milhan, Noala Vicensoto Triches, Eliandra de Sousa [UNIFESP] |
author_role |
author |
author2 |
de Paula, Cynthia Guimaraes [UNIFESP] Motisuke, Mariana [UNIFESP] Gouveia, Rubia Figueredo Afonso Camargo, Samira Esteves Moreira Milhan, Noala Vicensoto Triches, Eliandra de Sousa [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Siqueira, Lilian [UNIFESP] de Paula, Cynthia Guimaraes [UNIFESP] Motisuke, Mariana [UNIFESP] Gouveia, Rubia Figueredo Afonso Camargo, Samira Esteves Moreira Milhan, Noala Vicensoto Triches, Eliandra de Sousa [UNIFESP] |
dc.subject.eng.fl_str_mv |
Tricalcium phosphate alumina gel-casting method cytocompatibility scaffolds |
topic |
Tricalcium phosphate alumina gel-casting method cytocompatibility scaffolds |
description |
Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. beta-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, beta-TCP and beta-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (8688%) and pore sizes ranging from 200 to 500 mu m. Even though alumina did not promote improvement in beta-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, beta-TCP and beta-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-06-26T16:30:23Z |
dc.date.available.fl_str_mv |
2020-06-26T16:30:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.].fl_str_mv |
http://dx.doi.org/10.1590/1980-5373-MR-2016-0467 |
dc.identifier.citation.fl_str_mv |
Materials Research-Ibero-American Journal Of Materials. Sao Carlos, v. 20, n. 4, p. 973-983, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/53521 |
dc.identifier.issn.none.fl_str_mv |
1516-1439 |
dc.identifier.file.none.fl_str_mv |
S1516-14392017000400973.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1516-14392017000400973 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1980-5373-MR-2016-0467 |
dc.identifier.wos.none.fl_str_mv |
WOS:000410628100016 |
url |
http://dx.doi.org/10.1590/1980-5373-MR-2016-0467 https://repositorio.unifesp.br/handle/11600/53521 |
identifier_str_mv |
Materials Research-Ibero-American Journal Of Materials. Sao Carlos, v. 20, n. 4, p. 973-983, 2017. 1516-1439 S1516-14392017000400973.pdf S1516-14392017000400973 10.1590/1980-5373-MR-2016-0467 WOS:000410628100016 |
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eng |
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Materials Research-Ibero-American Journal Of Materials |
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info:eu-repo/semantics/openAccess |
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openAccess |
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973-983 |
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Sao Carlos |
dc.publisher.none.fl_str_mv |
Univ Fed Sao Carlos, Dept Engenharia Materials |
publisher.none.fl_str_mv |
Univ Fed Sao Carlos, Dept Engenharia Materials |
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