Impact of corticosteroids on late growth of radiofrequency lesions in infant pigs: histopathological and electroanatomical findings

• Autor(a) principal: Arfelli, Elerson [UNIFESP]
• Data de Publicação: 2011
• Outros Autores: Araujo, Sergio de [UNIFESP], Okada, Mieko [UNIFESP], Nascimento, Thais [UNIFESP], Santos, Luis Felipe N. dos [UNIFESP], Franco, Marcello [UNIFESP], Paola, Angelo A. V. de [UNIFESP], Fenelon, Guilherme [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/33189; http://dx.doi.org/10.1093/europace/euq391
• topic: Arrhythmias; Radiofrequency ablation; Electroanatomical mapping; Corticosteroids

Aims Corticosteroids attenuate late growth of radiofrequency (RF) lesions in the thigh muscle of infant rats. We sought to assess the impact of these drugs on the late growth of RF lesions in immature swine myocardium and to determine the electroanatomical mapping (EAM) characteristics of these lesions.Methods and results Radiofrequency (60 degrees C; 60 s) lesions were created in the right atrium (n = 2) and ventricle (n = 2) of 14 piglets (age 65 days; weight 5 kg) and 3 adults. Piglets were divided into: controls (n 7) and treated (n 7), receiving hydrocortisone (10 mg/kg iv after RF) and prednisone (1 mg/kg/day) for 29 days. After 8 months, animals were sacrificed for histological analysis. in four piglets, endocardial and epicardial voltage EAM were performed.In infant groups, the dimensions of atrial (11 +/- 5 vs. 13 +/- 7 mm) and ventricular (12 +/- 3 vs. 11 +/- 3 mm) lesions were similar. in adults, atrial (6 +/- 1 mm) and ventricular (6 +/- 1 mm) lesions were smaller. in controls, ventricular lesions depicted dense fibrosis and multiple strands of fibrous tissue extending from the lesion into normal muscle. Treated piglets revealed scars exhibiting less dense fibrosis with predominance of fibroadipose tissue and less collagen proliferation. Large atrial and ventricular low-voltage areas corresponding to the macroscopic lesions were identified in all animals.Conclusion Radiofrequency lesions in infant pigs reveal late growth and invasion of normal muscle by intense collagen proliferation. Corticosteroids do not prevent late enlargement of the lesions but modulate the fibrotic proliferation. the expressive growth of the lesion may generate low-voltage areas detectable by EAM.