cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/3174 http://dx.doi.org/10.1590/S1413-86702006000400008 |
Resumo: | Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development. |
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Gatti, Luciano Lobo [UNIFESP]Lábio, Roger Willian deSilva, Luiz Carlos daSmith, Marilia de Arruda Cardoso [UNIFESP]Payão, Spencer Luiz Marques [UNIFESP]School of Medicine of Marília Department of Genetic and Molecular Biology HemocentroUniversidade Federal de São Paulo (UNIFESP)FAMEMA Department of Pathology2015-06-14T13:36:21Z2015-06-14T13:36:21Z2006-08-01Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 254-258, 2006.1413-8670http://repositorio.unifesp.br/handle/11600/3174http://dx.doi.org/10.1590/S1413-86702006000400008S1413-86702006000400008.pdfS1413-8670200600040000810.1590/S1413-86702006000400008Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)School of Medicine of Marília Department of Genetic and Molecular Biology HemocentroUNIFESP-EPM Department of GeneticFAMEMA Department of PathologyUNIFESP, EPM, Department of GeneticSciELO254-258engBrazilian Society of Infectious DiseasesBrazilian Journal of Infectious DiseasesHelicobacter pylori infectioncagAinflammatory infiltratecagA positive Helicobacter pylori in Brazilian children related to chronic gastritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1413-86702006000400008.pdfapplication/pdf78674${dspace.ui.url}/bitstream/11600/3174/1/S1413-86702006000400008.pdfabdd746e64b89148bdfbb1d98b451671MD51open accessTEXTS1413-86702006000400008.pdf.txtS1413-86702006000400008.pdf.txtExtracted texttext/plain20087${dspace.ui.url}/bitstream/11600/3174/2/S1413-86702006000400008.pdf.txt515d93ca056d2b56d1f6706a65c214e8MD52open access11600/31742022-02-08 17:45:32.281open accessoai:repositorio.unifesp.br:11600/3174Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:10:09.040564Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
spellingShingle |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis Gatti, Luciano Lobo [UNIFESP] Helicobacter pylori infection cagA inflammatory infiltrate |
title_short |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_full |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_fullStr |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_full_unstemmed |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
title_sort |
cagA positive Helicobacter pylori in Brazilian children related to chronic gastritis |
author |
Gatti, Luciano Lobo [UNIFESP] |
author_facet |
Gatti, Luciano Lobo [UNIFESP] Lábio, Roger Willian de Silva, Luiz Carlos da Smith, Marilia de Arruda Cardoso [UNIFESP] Payão, Spencer Luiz Marques [UNIFESP] |
author_role |
author |
author2 |
Lábio, Roger Willian de Silva, Luiz Carlos da Smith, Marilia de Arruda Cardoso [UNIFESP] Payão, Spencer Luiz Marques [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
School of Medicine of Marília Department of Genetic and Molecular Biology Hemocentro Universidade Federal de São Paulo (UNIFESP) FAMEMA Department of Pathology |
dc.contributor.author.fl_str_mv |
Gatti, Luciano Lobo [UNIFESP] Lábio, Roger Willian de Silva, Luiz Carlos da Smith, Marilia de Arruda Cardoso [UNIFESP] Payão, Spencer Luiz Marques [UNIFESP] |
dc.subject.eng.fl_str_mv |
Helicobacter pylori infection cagA inflammatory infiltrate |
topic |
Helicobacter pylori infection cagA inflammatory infiltrate |
description |
Helicobacter pylori is a spiral-shaped Gram-negative bacterium. It colonizes the gastric mucosa of humans and persists for decades if not treated. Helicobacter pylori infection affects more than half of the world's population and invariably results in chronic gastritis. The cagA gene is present in about 60 to 70% of H. pylori strains; it encodes a high-molecular-weight protein (120 to 140 kDa) and several investigators have noted a correlation between strains that possess cagA and the severity of gastric mucosal inflammation. We examined the relation between cagA status in H. pylori strains and chronic gastritis with inflammatory processes in children from Marília, São Paulo, Brazil. One-hundred-twenty-one children were analyzed histopathologically and by polymerase chain reaction (PCR) to detect H. pylori and cagA. We then looked for an association between cagA presence and inflammatory infiltration. Using histology and PCR, we found 47% H. pylori positive infection; 29 children were diagnosed with chronic gastritis, while 28 showed normal mucosa by histopathological analysis. CagA presence was genotyped in both groups, and an inflammatory infiltrate was studied in all infected children with chronic gastritis. We found cagA strains in 20 of 29 (69%) children with chronic gastritis and 18 of 28 (64%) with normal mucosa, demonstrating a strong relationship between the strains and the inflammatory process. We found a positive association between an inflammatory process associated with H. pylori of cagA+ strains and chronic gastritis development. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-08-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:36:21Z |
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2015-06-14T13:36:21Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 254-258, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/3174 http://dx.doi.org/10.1590/S1413-86702006000400008 |
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1413-8670 |
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S1413-86702006000400008.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1413-86702006000400008 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1413-86702006000400008 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 4, p. 254-258, 2006. 1413-8670 S1413-86702006000400008.pdf S1413-86702006000400008 10.1590/S1413-86702006000400008 |
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http://repositorio.unifesp.br/handle/11600/3174 http://dx.doi.org/10.1590/S1413-86702006000400008 |
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eng |
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Brazilian Journal of Infectious Diseases |
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254-258 |
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Brazilian Society of Infectious Diseases |
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Brazilian Society of Infectious Diseases |
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