Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36204 http://dx.doi.org/10.1016/j.bbrc.2013.03.001 |
Resumo: | Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved. |
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Souza, Lucas R. deMelo, Pollyana Maria Saud [UNIFESP]Paschoalin, Thaysa [UNIFESP]Carmona, Adriana Karaoglanovic [UNIFESP]Kondo, Marcia Yuri [UNIFESP]Hirata, Izaura Yoshico [UNIFESP]Blaber, MichaelTersariol, Ivarne Luis dos Santos [UNIFESP]Takatsuka, JoyceJuliano, Maria Aparecida [UNIFESP]Juliano, Luiz [UNIFESP]Gomes, Roseli A.Puzer, LucianoUniversidade Federal do ABC (UFABC)Universidade Federal de São Paulo (UNIFESP)Florida State UnivUniv Mogi das CruzesUniv Fed Triangulo Mineiro2016-01-24T14:31:34Z2016-01-24T14:31:34Z2013-04-12Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013.0006-291Xhttp://repositorio.unifesp.br/handle/11600/36204http://dx.doi.org/10.1016/j.bbrc.2013.03.001WOS000318190400012.pdf10.1016/j.bbrc.2013.03.001WOS:000318190400012Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Univ Fed ABC, Ctr Ciencias Nat & Humanas, Santo Andre, SP, BrazilUniversidade Federal de São Paulo, Dept Biofis, Sao Carlos, SP, BrazilFlorida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USAUniv Mogi das Cruzes, Ctr Interdisciplinar Invest Bioquim, São Paulo, BrazilUniv Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Uberaba, MG, BrazilUniversidade Federal de São Paulo, Dept Biofis, Sao Carlos, SP, BrazilFAPESP: Proc 2011/51297-8CNPq: 312701/2009-8Web of Science333-337engElsevier B.V.Biochemical and Biophysical Research Communicationshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessPlasminogenPlasminKallikreinProteaseHuman tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000318190400012.pdfapplication/pdf515619${dspace.ui.url}/bitstream/11600/36204/1/WOS000318190400012.pdf9036f36793d37f89be7d889be0cd4acbMD51open accessTEXTWOS000318190400012.pdf.txtWOS000318190400012.pdf.txtExtracted texttext/plain22400${dspace.ui.url}/bitstream/11600/36204/2/WOS000318190400012.pdf.txtfd9a72cd5fa8117ce2916722e3bc722bMD52open access11600/362042022-06-02 10:24:16.124open accessoai:repositorio.unifesp.br:11600/36204Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:16:40.184883Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin |
title |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin |
spellingShingle |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin Souza, Lucas R. de Plasminogen Plasmin Kallikrein Protease |
title_short |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin |
title_full |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin |
title_fullStr |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin |
title_full_unstemmed |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin |
title_sort |
Human tissue kallikreins 3 and 5 can act as plasminogen activator releasing active plasmin |
author |
Souza, Lucas R. de |
author_facet |
Souza, Lucas R. de Melo, Pollyana Maria Saud [UNIFESP] Paschoalin, Thaysa [UNIFESP] Carmona, Adriana Karaoglanovic [UNIFESP] Kondo, Marcia Yuri [UNIFESP] Hirata, Izaura Yoshico [UNIFESP] Blaber, Michael Tersariol, Ivarne Luis dos Santos [UNIFESP] Takatsuka, Joyce Juliano, Maria Aparecida [UNIFESP] Juliano, Luiz [UNIFESP] Gomes, Roseli A. Puzer, Luciano |
author_role |
author |
author2 |
Melo, Pollyana Maria Saud [UNIFESP] Paschoalin, Thaysa [UNIFESP] Carmona, Adriana Karaoglanovic [UNIFESP] Kondo, Marcia Yuri [UNIFESP] Hirata, Izaura Yoshico [UNIFESP] Blaber, Michael Tersariol, Ivarne Luis dos Santos [UNIFESP] Takatsuka, Joyce Juliano, Maria Aparecida [UNIFESP] Juliano, Luiz [UNIFESP] Gomes, Roseli A. Puzer, Luciano |
author2_role |
author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal do ABC (UFABC) Universidade Federal de São Paulo (UNIFESP) Florida State Univ Univ Mogi das Cruzes Univ Fed Triangulo Mineiro |
dc.contributor.author.fl_str_mv |
Souza, Lucas R. de Melo, Pollyana Maria Saud [UNIFESP] Paschoalin, Thaysa [UNIFESP] Carmona, Adriana Karaoglanovic [UNIFESP] Kondo, Marcia Yuri [UNIFESP] Hirata, Izaura Yoshico [UNIFESP] Blaber, Michael Tersariol, Ivarne Luis dos Santos [UNIFESP] Takatsuka, Joyce Juliano, Maria Aparecida [UNIFESP] Juliano, Luiz [UNIFESP] Gomes, Roseli A. Puzer, Luciano |
dc.subject.eng.fl_str_mv |
Plasminogen Plasmin Kallikrein Protease |
topic |
Plasminogen Plasmin Kallikrein Protease |
description |
Human tissue kallikreins (KLKs) are a group of serine proteases found in many tissues and biological fluids and are differentially expressed in several specific pathologies. Here, we present evidences of the ability of these enzymes to activate plasminogen. Kallikreins 3 and 5 were able to induce plasmin activity after hydrolyzing plasminogen, and we also verified that plasminogen activation was potentiated in the presence of glycosaminoglycans compared with plasminogen activation by tPA. This finding can shed new light on the plasminogen/plasmin system and its involvement in tumor metastasis, in which kallikreins appear to be upregulated. (C) 2013 Elsevier Inc. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-04-12 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:34Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36204 http://dx.doi.org/10.1016/j.bbrc.2013.03.001 |
dc.identifier.issn.none.fl_str_mv |
0006-291X |
dc.identifier.file.none.fl_str_mv |
WOS000318190400012.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.bbrc.2013.03.001 |
dc.identifier.wos.none.fl_str_mv |
WOS:000318190400012 |
identifier_str_mv |
Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 433, n. 3, p. 333-337, 2013. 0006-291X WOS000318190400012.pdf 10.1016/j.bbrc.2013.03.001 WOS:000318190400012 |
url |
http://repositorio.unifesp.br/handle/11600/36204 http://dx.doi.org/10.1016/j.bbrc.2013.03.001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Biochemical and Biophysical Research Communications |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
dc.format.none.fl_str_mv |
333-337 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
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Elsevier B.V. |
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