Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels
Autor(a) principal: | |
---|---|
Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/3282 https://dx.doi.org/10.1590/S0100-879X2006001000006 |
Resumo: | Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were re-analyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54% according to criteria used to define it (serum creatinine> or = 1.5 mg/dL and creatinine clearance <60 mL/min). Mean serum creatinine was 1.61 ± 1.31 mg/dL (range 0.7 to 9.8 mg/dL) and calculated and measured creatinine clearances were 67.7 ± 25.9 and 61.18 ± 25.04 mL min-1 (1.73 m²)-1, respectively. Sixteen of the 43 patients who completed the follow-up (37.2%) had tubular dysfunction detected by increased levels of uRBP (median 1.06, 0.412-6.396 mg/dL). Eleven of the 16 patients (68.7%) with elevated uRBP had poorer renal function after 18 months of follow-up, compared with only eight of the 27 patients (29.6%) with normal uRBP (RR = 3.47, P = 0.0095). Interestingly, cyclosporine trough levels were not different between patients with or without tubular and glomerular dysfunction. Renal function impairment is common after heart transplantation. Tubular dysfunction, assessed by uRBP, correlates with a worsening of glomerular filtration and can be a useful tool for early detection of renal dysfunction. |
id |
UFSP_23aea7cf4df09c124ec146e6539de45a |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/3282 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Chinen, Rogerio [UNIFESP]Câmara, Niels Olsen Saraiva [UNIFESP]Nishida, Sonia Kiyomi [UNIFESP]Silva, Marcelo de Souza [UNIFESP]Rodrigues, Dirceu Almeida [UNIFESP]Pereira, Aparecido Bernardo [UNIFESP]Pacheco-Silva, Alvaro [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:36:28Z2015-06-14T13:36:28Z2006-10-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1305-1313, 2006.0100-879Xhttps://repositorio.unifesp.br/handle/11600/3282https://dx.doi.org/10.1590/S0100-879X2006001000006S0100-879X2006001000006.pdfS0100-879X200600100000610.1590/S0100-879X2006001000006WOS:000242173300006Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were re-analyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54% according to criteria used to define it (serum creatinine> or = 1.5 mg/dL and creatinine clearance <60 mL/min). Mean serum creatinine was 1.61 ± 1.31 mg/dL (range 0.7 to 9.8 mg/dL) and calculated and measured creatinine clearances were 67.7 ± 25.9 and 61.18 ± 25.04 mL min-1 (1.73 m²)-1, respectively. Sixteen of the 43 patients who completed the follow-up (37.2%) had tubular dysfunction detected by increased levels of uRBP (median 1.06, 0.412-6.396 mg/dL). Eleven of the 16 patients (68.7%) with elevated uRBP had poorer renal function after 18 months of follow-up, compared with only eight of the 27 patients (29.6%) with normal uRBP (RR = 3.47, P = 0.0095). Interestingly, cyclosporine trough levels were not different between patients with or without tubular and glomerular dysfunction. Renal function impairment is common after heart transplantation. Tubular dysfunction, assessed by uRBP, correlates with a worsening of glomerular filtration and can be a useful tool for early detection of renal dysfunction.Universidade Federal de São Paulo (UNIFESP) Disciplina de Nefrologia Laboratório de Imunologia Clínica e ExperimentalUniversidade Federal de São Paulo (UNIFESP) Disciplina de CardiologiaUNIFESP, Disciplina de Nefrologia Laboratório de Imunologia Clínica e ExperimentalUNIFESP, Disciplina de CardiologiaSciELO1305-1313engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchRenal functionUrinary retinol-binding proteinHeart transplantGraft survivalChronic renal failureDetermination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levelsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2006001000006.pdfapplication/pdf502812${dspace.ui.url}/bitstream/11600/3282/1/S0100-879X2006001000006.pdfd8a8939c1f74da449066208ed77aa306MD51open accessTEXTS0100-879X2006001000006.pdf.txtS0100-879X2006001000006.pdf.txtExtracted texttext/plain36879${dspace.ui.url}/bitstream/11600/3282/2/S0100-879X2006001000006.pdf.txt154a7965fa6d8f610f979d61bece6df4MD52open access11600/32822023-08-14 20:31:41.861open accessRepositório InstitucionalPUB |
dc.title.en.fl_str_mv |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels |
title |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels |
spellingShingle |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels Chinen, Rogerio [UNIFESP] Renal function Urinary retinol-binding protein Heart transplant Graft survival Chronic renal failure |
title_short |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels |
title_full |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels |
title_fullStr |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels |
title_full_unstemmed |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels |
title_sort |
Determination of renal function in long-term heart transplant patients by measurement of urinary retinol-binding protein levels |
author |
Chinen, Rogerio [UNIFESP] |
author_facet |
Chinen, Rogerio [UNIFESP] Câmara, Niels Olsen Saraiva [UNIFESP] Nishida, Sonia Kiyomi [UNIFESP] Silva, Marcelo de Souza [UNIFESP] Rodrigues, Dirceu Almeida [UNIFESP] Pereira, Aparecido Bernardo [UNIFESP] Pacheco-Silva, Alvaro [UNIFESP] |
author_role |
author |
author2 |
Câmara, Niels Olsen Saraiva [UNIFESP] Nishida, Sonia Kiyomi [UNIFESP] Silva, Marcelo de Souza [UNIFESP] Rodrigues, Dirceu Almeida [UNIFESP] Pereira, Aparecido Bernardo [UNIFESP] Pacheco-Silva, Alvaro [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Chinen, Rogerio [UNIFESP] Câmara, Niels Olsen Saraiva [UNIFESP] Nishida, Sonia Kiyomi [UNIFESP] Silva, Marcelo de Souza [UNIFESP] Rodrigues, Dirceu Almeida [UNIFESP] Pereira, Aparecido Bernardo [UNIFESP] Pacheco-Silva, Alvaro [UNIFESP] |
dc.subject.eng.fl_str_mv |
Renal function Urinary retinol-binding protein Heart transplant Graft survival Chronic renal failure |
topic |
Renal function Urinary retinol-binding protein Heart transplant Graft survival Chronic renal failure |
description |
Significant improvements have been noted in heart transplantation with the advent of cyclosporine. However, cyclosporine use is associated with significant side effects, such as chronic renal failure. We were interested in evaluating the incidence of long-term renal dysfunction in heart transplant recipients. Fifty-three heart transplant recipients were enrolled in the study. Forty-three patients completed the entire evaluation and follow-up. Glomerular (serum creatinine, creatinine clearance measured, and creatinine clearance calculated) and tubular functions (urinary retinol-binding protein, uRBP) were re-analyzed after 18 months. At the enrollment time, the prevalence of renal failure ranged from 37.7 to 54% according to criteria used to define it (serum creatinine> or = 1.5 mg/dL and creatinine clearance <60 mL/min). Mean serum creatinine was 1.61 ± 1.31 mg/dL (range 0.7 to 9.8 mg/dL) and calculated and measured creatinine clearances were 67.7 ± 25.9 and 61.18 ± 25.04 mL min-1 (1.73 m²)-1, respectively. Sixteen of the 43 patients who completed the follow-up (37.2%) had tubular dysfunction detected by increased levels of uRBP (median 1.06, 0.412-6.396 mg/dL). Eleven of the 16 patients (68.7%) with elevated uRBP had poorer renal function after 18 months of follow-up, compared with only eight of the 27 patients (29.6%) with normal uRBP (RR = 3.47, P = 0.0095). Interestingly, cyclosporine trough levels were not different between patients with or without tubular and glomerular dysfunction. Renal function impairment is common after heart transplantation. Tubular dysfunction, assessed by uRBP, correlates with a worsening of glomerular filtration and can be a useful tool for early detection of renal dysfunction. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-10-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:36:28Z |
dc.date.available.fl_str_mv |
2015-06-14T13:36:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1305-1313, 2006. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/3282 https://dx.doi.org/10.1590/S0100-879X2006001000006 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2006001000006.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2006001000006 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2006001000006 |
dc.identifier.wos.none.fl_str_mv |
WOS:000242173300006 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 10, p. 1305-1313, 2006. 0100-879X S0100-879X2006001000006.pdf S0100-879X2006001000006 10.1590/S0100-879X2006001000006 WOS:000242173300006 |
url |
https://repositorio.unifesp.br/handle/11600/3282 https://dx.doi.org/10.1590/S0100-879X2006001000006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1305-1313 |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/3282/1/S0100-879X2006001000006.pdf ${dspace.ui.url}/bitstream/11600/3282/2/S0100-879X2006001000006.pdf.txt |
bitstream.checksum.fl_str_mv |
d8a8939c1f74da449066208ed77aa306 154a7965fa6d8f610f979d61bece6df4 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
|
repository.mail.fl_str_mv |
|
_version_ |
1783460231781548032 |