Pupil size following dark adaptation in patients with retinitis pigmentosa
Autor(a) principal: | |
---|---|
Data de Publicação: | 2001 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/26597 http://dx.doi.org/10.1590/S0100-879X2001000800010 |
Resumo: | According to the equivalent light hypothesis, molecular defects in the photoreceptor lead to a continuous activation of the photoreceptor cascade in a manner equivalent to real light. the consequences in diseases such as retinitis pigmentosa (RP) are as disruptive to the cells as real light. Two forms of the equivalent light hypothesis can be distinguished: strong - mutations in rhodopsin or other cascade proteins in some forms of RP continuously excite the visual phototransduction cascade, weak - disruption of outer segments in all patients with RP eliminates circulating dark current and blocks neurotransmitter release in a manner similar to real light. Both forms of the equivalent light hypothesis predict that pupils of patients with RP will be constricted like those of normal subjects in the light. the purpose of this study was to test the equivalent light hypothesis by determining whether steady-state pupil diameter following full dark adaptation is abnormally small in any of a sample of patients with RP. Thirty-five patients with RP and 15 normal subjects were tested. Direct steady-state pupillometric measures were obtained from one eye in a full-field dome after 45 min of dark adaptation by videotaping the pupil with an infrared camera. Mean pupil diameter in the dark was comparable (t = -0.15. P = 0.88) between patients with RP (6.85 +/- 0.58 min) and normal subjects (6.82 +/- 0.76 mm). the results of the present study are clearly counter to the prediction of the second (weaker) form of the equivalent light hypothesis. |
id |
UFSP_27be3bea859312c0804a5b89fe16f5b7 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/26597 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Berezovsky, Adriana [UNIFESP]Salomão, Solange Rios [UNIFESP]Birch, D. G.Universidade Federal de São Paulo (UNIFESP)Retina Fdn SW2016-01-24T12:31:26Z2016-01-24T12:31:26Z2001-08-01Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 34, n. 8, p. 1037-1040, 2001.0100-879Xhttp://repositorio.unifesp.br/handle/11600/26597http://dx.doi.org/10.1590/S0100-879X2001000800010S0100-879X200100080001010.1590/S0100-879X2001000800010WOS:000170731800010According to the equivalent light hypothesis, molecular defects in the photoreceptor lead to a continuous activation of the photoreceptor cascade in a manner equivalent to real light. the consequences in diseases such as retinitis pigmentosa (RP) are as disruptive to the cells as real light. Two forms of the equivalent light hypothesis can be distinguished: strong - mutations in rhodopsin or other cascade proteins in some forms of RP continuously excite the visual phototransduction cascade, weak - disruption of outer segments in all patients with RP eliminates circulating dark current and blocks neurotransmitter release in a manner similar to real light. Both forms of the equivalent light hypothesis predict that pupils of patients with RP will be constricted like those of normal subjects in the light. the purpose of this study was to test the equivalent light hypothesis by determining whether steady-state pupil diameter following full dark adaptation is abnormally small in any of a sample of patients with RP. Thirty-five patients with RP and 15 normal subjects were tested. Direct steady-state pupillometric measures were obtained from one eye in a full-field dome after 45 min of dark adaptation by videotaping the pupil with an infrared camera. Mean pupil diameter in the dark was comparable (t = -0.15. P = 0.88) between patients with RP (6.85 +/- 0.58 min) and normal subjects (6.82 +/- 0.76 mm). the results of the present study are clearly counter to the prediction of the second (weaker) form of the equivalent light hypothesis.Universidade Federal de São Paulo, Dept Oftalmol, BR-04023062 São Paulo, SP, BrazilRetina Fdn SW, Dallas, TX USAUniversidade Federal de São Paulo, Dept Oftalmol, BR-04023062 São Paulo, SP, BrazilWeb of Science1037-1040engAssoc Bras Divulg CientificaBrazilian Journal of Medical and Biological Researchpupilretinaretinitis pigmentosaPupil size following dark adaptation in patients with retinitis pigmentosainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2001000800010.pdfS0100-879X2001000800010.pdfapplication/pdf184887${dspace.ui.url}/bitstream/11600/26597/1/S0100-879X2001000800010.pdf74aaaf2d125a312f1a511836d5d11226MD51metadata only access11600/265972023-02-15 09:30:33.543metadata only accessoai:repositorio.unifesp.br:11600/26597Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:00.289489Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Pupil size following dark adaptation in patients with retinitis pigmentosa |
title |
Pupil size following dark adaptation in patients with retinitis pigmentosa |
spellingShingle |
Pupil size following dark adaptation in patients with retinitis pigmentosa Berezovsky, Adriana [UNIFESP] pupil retina retinitis pigmentosa |
title_short |
Pupil size following dark adaptation in patients with retinitis pigmentosa |
title_full |
Pupil size following dark adaptation in patients with retinitis pigmentosa |
title_fullStr |
Pupil size following dark adaptation in patients with retinitis pigmentosa |
title_full_unstemmed |
Pupil size following dark adaptation in patients with retinitis pigmentosa |
title_sort |
Pupil size following dark adaptation in patients with retinitis pigmentosa |
author |
Berezovsky, Adriana [UNIFESP] |
author_facet |
Berezovsky, Adriana [UNIFESP] Salomão, Solange Rios [UNIFESP] Birch, D. G. |
author_role |
author |
author2 |
Salomão, Solange Rios [UNIFESP] Birch, D. G. |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Retina Fdn SW |
dc.contributor.author.fl_str_mv |
Berezovsky, Adriana [UNIFESP] Salomão, Solange Rios [UNIFESP] Birch, D. G. |
dc.subject.eng.fl_str_mv |
pupil retina retinitis pigmentosa |
topic |
pupil retina retinitis pigmentosa |
description |
According to the equivalent light hypothesis, molecular defects in the photoreceptor lead to a continuous activation of the photoreceptor cascade in a manner equivalent to real light. the consequences in diseases such as retinitis pigmentosa (RP) are as disruptive to the cells as real light. Two forms of the equivalent light hypothesis can be distinguished: strong - mutations in rhodopsin or other cascade proteins in some forms of RP continuously excite the visual phototransduction cascade, weak - disruption of outer segments in all patients with RP eliminates circulating dark current and blocks neurotransmitter release in a manner similar to real light. Both forms of the equivalent light hypothesis predict that pupils of patients with RP will be constricted like those of normal subjects in the light. the purpose of this study was to test the equivalent light hypothesis by determining whether steady-state pupil diameter following full dark adaptation is abnormally small in any of a sample of patients with RP. Thirty-five patients with RP and 15 normal subjects were tested. Direct steady-state pupillometric measures were obtained from one eye in a full-field dome after 45 min of dark adaptation by videotaping the pupil with an infrared camera. Mean pupil diameter in the dark was comparable (t = -0.15. P = 0.88) between patients with RP (6.85 +/- 0.58 min) and normal subjects (6.82 +/- 0.76 mm). the results of the present study are clearly counter to the prediction of the second (weaker) form of the equivalent light hypothesis. |
publishDate |
2001 |
dc.date.issued.fl_str_mv |
2001-08-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:31:26Z |
dc.date.available.fl_str_mv |
2016-01-24T12:31:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 34, n. 8, p. 1037-1040, 2001. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/26597 http://dx.doi.org/10.1590/S0100-879X2001000800010 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2001000800010 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2001000800010 |
dc.identifier.wos.none.fl_str_mv |
WOS:000170731800010 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 34, n. 8, p. 1037-1040, 2001. 0100-879X S0100-879X2001000800010 10.1590/S0100-879X2001000800010 WOS:000170731800010 |
url |
http://repositorio.unifesp.br/handle/11600/26597 http://dx.doi.org/10.1590/S0100-879X2001000800010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1037-1040 |
dc.publisher.none.fl_str_mv |
Assoc Bras Divulg Cientifica |
publisher.none.fl_str_mv |
Assoc Bras Divulg Cientifica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/26597/1/S0100-879X2001000800010.pdf |
bitstream.checksum.fl_str_mv |
74aaaf2d125a312f1a511836d5d11226 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460301481443328 |