What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1186/s12885-017-3391-5 https://repositorio.unifesp.br/handle/11600/53653 |
Resumo: | Background: Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radiotherapy) on clinical outcomes such as survival and recurrence in patients with non-metastatic Ewing sarcoma treated on the first Brazilian Collaborative Group Trial of the Ewing Family of Tumors (EWING1). Methods: Seventy-three patients with localized Ewing sarcoma of bone aged < 30 years were included. The treating physicians defined the modality of local control based on the recommendations of the coordinating center and the patient and tumor characteristics. Possible associations of local control modality with local failure (LF), disease-free survival (DFS), event-free survival (EFS), overall survival (OS), and clinical characteristics were analyzed. Results: Mean patient age was 12.8 years (range, 2 to 25 years) and median follow-up time was 4.5 years (range, 2. 3 to 6.7 years). Forty-seven patients underwent surgery, 13 received radiotherapy, and 13 received both. The 5-year EFS, OS, and DFS for all patients was 62.1%, 63.3%, and 73.1%, respectively. The 5-year cumulative incidence (CI) of LF was 7.6% for surgery, 11.1% for radiotherapy, and 0% for postoperative radiotherapy (PORT) (p = 0.61). The 5-year EFS was 71.7% for surgery, 30.8% for radiotherapy, and 64.1% for PORT (p = 0.009). Conclusions: There was a significant effect of local control modality on EFS and OS in the study. Surgery and PORT modalities yielded very close results. The group treated with radiotherapy alone had considerably worse outcomes. This may be confounded by greater risk factors in these patients. There was no significant effect of local control modality on the CI of LF and DFS. |
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Becker, Ricardo G.Gregianin, Lauro J.Galia, Carlos R.Jesus-Garcia Filho, Reynaldo [UNIFESP]Toller, Eduardo A.Badell, GerardoNakagawa, Suely A.David, AlexandreBaptista, Andre M.Yonamime, Eduardo S.Serafini, Osvaldo A.Penna, ValterSantos, Julie Francine C.Brunetto, Algemir L.2020-06-26T16:30:36Z2020-06-26T16:30:36Z2017http://dx.doi.org/10.1186/s12885-017-3391-5Bmc Cancer. London, v. 17, p. -, 2017.1471-2407https://repositorio.unifesp.br/handle/11600/53653WOS000403379500006.pdf10.1186/s12885-017-3391-5WOS:000403379500006Background: Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radiotherapy) on clinical outcomes such as survival and recurrence in patients with non-metastatic Ewing sarcoma treated on the first Brazilian Collaborative Group Trial of the Ewing Family of Tumors (EWING1). Methods: Seventy-three patients with localized Ewing sarcoma of bone aged < 30 years were included. The treating physicians defined the modality of local control based on the recommendations of the coordinating center and the patient and tumor characteristics. Possible associations of local control modality with local failure (LF), disease-free survival (DFS), event-free survival (EFS), overall survival (OS), and clinical characteristics were analyzed. Results: Mean patient age was 12.8 years (range, 2 to 25 years) and median follow-up time was 4.5 years (range, 2. 3 to 6.7 years). Forty-seven patients underwent surgery, 13 received radiotherapy, and 13 received both. The 5-year EFS, OS, and DFS for all patients was 62.1%, 63.3%, and 73.1%, respectively. The 5-year cumulative incidence (CI) of LF was 7.6% for surgery, 11.1% for radiotherapy, and 0% for postoperative radiotherapy (PORT) (p = 0.61). The 5-year EFS was 71.7% for surgery, 30.8% for radiotherapy, and 64.1% for PORT (p = 0.009). Conclusions: There was a significant effect of local control modality on EFS and OS in the study. Surgery and PORT modalities yielded very close results. The group treated with radiotherapy alone had considerably worse outcomes. This may be confounded by greater risk factors in these patients. There was no significant effect of local control modality on the CI of LF and DFS.Children's Cancer InstituteRafael Accordi Foundation, Porto Alegre, RS, BrazilHCPA, Serv Orthoped & Traumatol, Rua Ramiro Barcelos 2350, BR-90035903 Porto Alegre, RS, BrazilUniv Fed Rio Grande do Sul, HCPA, Dept Pediat, Porto Alegre, RS, BrazilPontificia Univ Catolica Rio Grande Sul PUCRS, Dept Pediat, Hosp Sao Lucas, Porto Alegre, RS, BrazilHCPA, Serv Orthoped & Traumatol, Porto Alegre, RS, BrazilUniv Fed Sao Paulo UNIFESP, Support Grp Children & Adolescents Canc GRAACC, Sao Paulo, SP, BrazilHosp Canc Infantojuvenil, Fundacao Pio 12, Barretos, SP, BrazilCtr Hosp Pereira Rossell, Montevideo, UruguayHosp AC Camargo Canc Ctr, Orthoped Serv, Sao Paulo, SP, BrazilSanta Casa Misericordia Porto Alegre, Serv Orthoped & Traumatol, Porto Alegre, RS, BrazilUniv Sao Paulo, Orthoped Trauma Inst, Hosp Clin Sao Paulo, Sch Med, Sao Paulo, SP, BrazilSanta Casa Misericordia Sao Paulo HSCSP, Dept Orthoped & Traumatol, Sao Paulo, SP, BrazilPontificia Univ Catolica Rio Grande Sul PUCRS, Hosp Sao Lucas, Serv Orthoped & Traumatol, Porto Alegre, RS, BrazilUniv Estadual Paulista UNESP, Hosp Clin Botucatu, Sch Med, Botucatu, SP, BrazilInst Canc Infantil, Porto Alegre, RS, BrazilUniv Fed Sao Paulo UNIFESP, Support Grp Children & Adolescents Canc GRAACC, Sao Paulo, SP, BrazilChildren's Cancer InstituteRafael Accordi Foundation, Porto Alegre, RS, BrazilWeb of Science-engBiomed Central LtdBmc CancerEwing sarcomaLocal controlRadiation oncologySurgeryBone tumorsOrthopedicsWhat is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondon17info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000403379500006.pdfapplication/pdf557601${dspace.ui.url}/bitstream/11600/53653/1/WOS000403379500006.pdfec24d70f5874d52569293e448c7b3e82MD51open accessTEXTWOS000403379500006.pdf.txtWOS000403379500006.pdf.txtExtracted texttext/plain36654${dspace.ui.url}/bitstream/11600/53653/2/WOS000403379500006.pdf.txt3d95be1b4fc2c2abef892d92a5cacd46MD52open accessTHUMBNAILWOS000403379500006.pdf.jpgWOS000403379500006.pdf.jpgIM Thumbnailimage/jpeg6371${dspace.ui.url}/bitstream/11600/53653/4/WOS000403379500006.pdf.jpgbbc1213aef7b07aa69d8d8e47ab41025MD54open access11600/536532022-08-01 09:48:16.938open accessoai:repositorio.unifesp.br:11600/53653Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:20:18.109022Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 |
title |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 |
spellingShingle |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 Becker, Ricardo G. Ewing sarcoma Local control Radiation oncology Surgery Bone tumors Orthopedics |
title_short |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 |
title_full |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 |
title_fullStr |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 |
title_full_unstemmed |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 |
title_sort |
What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group-EWING1 |
author |
Becker, Ricardo G. |
author_facet |
Becker, Ricardo G. Gregianin, Lauro J. Galia, Carlos R. Jesus-Garcia Filho, Reynaldo [UNIFESP] Toller, Eduardo A. Badell, Gerardo Nakagawa, Suely A. David, Alexandre Baptista, Andre M. Yonamime, Eduardo S. Serafini, Osvaldo A. Penna, Valter Santos, Julie Francine C. Brunetto, Algemir L. |
author_role |
author |
author2 |
Gregianin, Lauro J. Galia, Carlos R. Jesus-Garcia Filho, Reynaldo [UNIFESP] Toller, Eduardo A. Badell, Gerardo Nakagawa, Suely A. David, Alexandre Baptista, Andre M. Yonamime, Eduardo S. Serafini, Osvaldo A. Penna, Valter Santos, Julie Francine C. Brunetto, Algemir L. |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Becker, Ricardo G. Gregianin, Lauro J. Galia, Carlos R. Jesus-Garcia Filho, Reynaldo [UNIFESP] Toller, Eduardo A. Badell, Gerardo Nakagawa, Suely A. David, Alexandre Baptista, Andre M. Yonamime, Eduardo S. Serafini, Osvaldo A. Penna, Valter Santos, Julie Francine C. Brunetto, Algemir L. |
dc.subject.eng.fl_str_mv |
Ewing sarcoma Local control Radiation oncology Surgery Bone tumors Orthopedics |
topic |
Ewing sarcoma Local control Radiation oncology Surgery Bone tumors Orthopedics |
description |
Background: Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radiotherapy) on clinical outcomes such as survival and recurrence in patients with non-metastatic Ewing sarcoma treated on the first Brazilian Collaborative Group Trial of the Ewing Family of Tumors (EWING1). Methods: Seventy-three patients with localized Ewing sarcoma of bone aged < 30 years were included. The treating physicians defined the modality of local control based on the recommendations of the coordinating center and the patient and tumor characteristics. Possible associations of local control modality with local failure (LF), disease-free survival (DFS), event-free survival (EFS), overall survival (OS), and clinical characteristics were analyzed. Results: Mean patient age was 12.8 years (range, 2 to 25 years) and median follow-up time was 4.5 years (range, 2. 3 to 6.7 years). Forty-seven patients underwent surgery, 13 received radiotherapy, and 13 received both. The 5-year EFS, OS, and DFS for all patients was 62.1%, 63.3%, and 73.1%, respectively. The 5-year cumulative incidence (CI) of LF was 7.6% for surgery, 11.1% for radiotherapy, and 0% for postoperative radiotherapy (PORT) (p = 0.61). The 5-year EFS was 71.7% for surgery, 30.8% for radiotherapy, and 64.1% for PORT (p = 0.009). Conclusions: There was a significant effect of local control modality on EFS and OS in the study. Surgery and PORT modalities yielded very close results. The group treated with radiotherapy alone had considerably worse outcomes. This may be confounded by greater risk factors in these patients. There was no significant effect of local control modality on the CI of LF and DFS. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-06-26T16:30:36Z |
dc.date.available.fl_str_mv |
2020-06-26T16:30:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.].fl_str_mv |
http://dx.doi.org/10.1186/s12885-017-3391-5 |
dc.identifier.citation.fl_str_mv |
Bmc Cancer. London, v. 17, p. -, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/53653 |
dc.identifier.issn.none.fl_str_mv |
1471-2407 |
dc.identifier.file.none.fl_str_mv |
WOS000403379500006.pdf |
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10.1186/s12885-017-3391-5 |
dc.identifier.wos.none.fl_str_mv |
WOS:000403379500006 |
url |
http://dx.doi.org/10.1186/s12885-017-3391-5 https://repositorio.unifesp.br/handle/11600/53653 |
identifier_str_mv |
Bmc Cancer. London, v. 17, p. -, 2017. 1471-2407 WOS000403379500006.pdf 10.1186/s12885-017-3391-5 WOS:000403379500006 |
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eng |
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eng |
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Bmc Cancer |
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London |
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Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
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