The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/49561 http://dx.doi.org/10.1155/2016/3797139 |
Resumo: | Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female andmaleWistar rats (n = 108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (mu EDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones. |
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Lodi, Karina BortolinPereira da Silva Marchini, Adriana Mathiasdo Espirito Santo, Ana Maria [UNIFESP]Rode, Sigmar de MelloMarchini, Leonardoda Rocha, Rosilene Fernandes2019-01-21T10:30:04Z2019-01-21T10:30:04Z2016International Journal Of Endocrinology. New York, 2016.1687-8337http://repositorio.unifesp.br/handle/11600/49561http://dx.doi.org/10.1155/2016/3797139WOS000373141900001.pdf10.1155/2016/3797139WOS:000373141900001Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female andmaleWistar rats (n = 108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (mu EDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones.National Council for Scientific and Technological Development (CNPq-Brazil)Brazilian governmental research agency, National Council for Scientific and Technological Development (CNPq-Brazil)Institute of Science and Technology, Department of Biosciences and Diagnostics, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, BrazilInstitute of Environmental Science, Chemical and Pharmaceutical, Department of Mathematical and Earth Sciences, Federal University of São Paulo (UNIFESP), Rua Prof. Artur Riedel 275, 09972-270 Diadema, SP, BrazilInstitute of Research and Development, University of Vale do Paraíba (UNIVAP), Laboratory of Biomedical Vibrational Spectroscopy, Avenida Shishima Hifumi 2911, 12244-000 São José dos Campos, SP, BrazilInstitute of Science and Technology, Department of Dental Materials and Prosthesis, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, BrazilDepartment of Preventive and Community Dentistry, The University of Iowa College of Dentistry and Dental Clinics, N337-1 Dental Science N, 52242 Iowa City, IA, USAInstitute of Environmental Science, Chemical and Pharmaceutical, Department of Mathematical and Earth Sciences, Federal University of São Paulo (UNIFESP), Rua Prof. Artur Riedel 275, 09972-270 Diadema, SP, BrazilWeb of ScienceengHindawi publishing corpInternational Journal Of EndocrinologyAlveolar Bone CrestEstrogen DeficiencyTrabecular BoneCortical BoneBody-WeightPhosphorusFracturesCalciumWomenOsteoporosisThe influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000373141900001.pdfapplication/pdf1433046${dspace.ui.url}/bitstream/11600/49561/1/WOS000373141900001.pdf0d766fb79e07f0595935dfc8d8206ef4MD51open accessTEXTWOS000373141900001.pdf.txtWOS000373141900001.pdf.txtExtracted texttext/plain50046${dspace.ui.url}/bitstream/11600/49561/8/WOS000373141900001.pdf.txt70ff99d577691410524283197755536bMD58open accessTHUMBNAILWOS000373141900001.pdf.jpgWOS000373141900001.pdf.jpgIM Thumbnailimage/jpeg6605${dspace.ui.url}/bitstream/11600/49561/10/WOS000373141900001.pdf.jpg8a6836ac0dacb084e53b95ee070f7604MD510open access11600/495612023-06-05 19:28:32.652open accessoai:repositorio.unifesp.br:11600/49561Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:28:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats |
title |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats |
spellingShingle |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats Lodi, Karina Bortolin Alveolar Bone Crest Estrogen Deficiency Trabecular Bone Cortical Bone Body-Weight Phosphorus Fractures Calcium Women Osteoporosis |
title_short |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats |
title_full |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats |
title_fullStr |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats |
title_full_unstemmed |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats |
title_sort |
The influence of alcohol consumption in conjunction with sex hormone deficiency on ca/p ratio in rats |
author |
Lodi, Karina Bortolin |
author_facet |
Lodi, Karina Bortolin Pereira da Silva Marchini, Adriana Mathias do Espirito Santo, Ana Maria [UNIFESP] Rode, Sigmar de Mello Marchini, Leonardo da Rocha, Rosilene Fernandes |
author_role |
author |
author2 |
Pereira da Silva Marchini, Adriana Mathias do Espirito Santo, Ana Maria [UNIFESP] Rode, Sigmar de Mello Marchini, Leonardo da Rocha, Rosilene Fernandes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Lodi, Karina Bortolin Pereira da Silva Marchini, Adriana Mathias do Espirito Santo, Ana Maria [UNIFESP] Rode, Sigmar de Mello Marchini, Leonardo da Rocha, Rosilene Fernandes |
dc.subject.eng.fl_str_mv |
Alveolar Bone Crest Estrogen Deficiency Trabecular Bone Cortical Bone Body-Weight Phosphorus Fractures Calcium Women Osteoporosis |
topic |
Alveolar Bone Crest Estrogen Deficiency Trabecular Bone Cortical Bone Body-Weight Phosphorus Fractures Calcium Women Osteoporosis |
description |
Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female andmaleWistar rats (n = 108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (mu EDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones. |
publishDate |
2016 |
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2016 |
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2019-01-21T10:30:04Z |
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dc.identifier.citation.fl_str_mv |
International Journal Of Endocrinology. New York, 2016. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/49561 http://dx.doi.org/10.1155/2016/3797139 |
dc.identifier.issn.none.fl_str_mv |
1687-8337 |
dc.identifier.file.none.fl_str_mv |
WOS000373141900001.pdf |
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10.1155/2016/3797139 |
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WOS:000373141900001 |
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International Journal Of Endocrinology. New York, 2016. 1687-8337 WOS000373141900001.pdf 10.1155/2016/3797139 WOS:000373141900001 |
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http://repositorio.unifesp.br/handle/11600/49561 http://dx.doi.org/10.1155/2016/3797139 |
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eng |
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Hindawi publishing corp |
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Hindawi publishing corp |
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