The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/7914 http://dx.doi.org/10.1590/1516-4446-2012-0922 |
Resumo: | Objective: Functional neuroimaging techniques represent fundamental tools in the context of translational research integrating neurobiology, psychopathology, neuropsychology, and therapeutics. In addition, cognitive-behavioral therapy (CBT) has proven its efficacy in the treatment of anxiety disorders and may be useful in phobias. The literature has shown that feelings and behaviors are mediated by specific brain circuits, and changes in patterns of interaction should be associated with cerebral alterations. Based on these concepts, a systematic review was conducted aiming to evaluate the impact of CBT on phobic disorders measured by functional neuroimaging techniques. Methods: A systematic review of the literature was conducted including studies published between January 1980 and April 2012. Studies written in English, Spanish or Portuguese evaluating changes in the pattern of functional neuroimaging before and after CBT in patients with phobic disorders were included. Results: The initial search strategy retrieved 45 studies. Six of these studies met all inclusion criteria. Significant deactivations in the amygdala, insula, thalamus and hippocampus, as well as activation of the medial orbitofrontal cortex, were observed after CBT in phobic patients when compared with controls. Conclusion: In spite of their technical limitations, neuroimaging techniques provide neurobiological support for the efficacy of CBT in the treatment of phobic disorders. Further studies are needed to confirm this conclusion. |
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Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP]Araujo Filho, Gerardo Maria de [UNIFESP]Berberian, Arthur de Almeida [UNIFESP]Trezsniak, ClarissaNery-Fernandes, FabianaAraujo Neto, Cesar AugustoJackowski, Andrea Parolin [UNIFESP]Miranda-Scippa, Ângela Marisa de Aquino [UNIFESP]Oliveira, Irismar Reis deUniversidade Federal da Bahia School of Medicine Department of Neurosciences and Mental HealthUniversidade Federal de São Paulo (UNIFESP)Faculdade de Medicina de São José do Rio Preto Department of Psychiatry and Medical PsychologyUniversidade de São Paulo (USP)King's College London Institute of Psychiatry Department of Psychosis StudiesUFBA Medical School Department of Imaging Diagnosis2015-06-14T13:45:35Z2015-06-14T13:45:35Z2013-09-01Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 3, p. 279-283, 2013.1516-4446http://repositorio.unifesp.br/handle/11600/7914http://dx.doi.org/10.1590/1516-4446-2012-0922S1516-44462013000300279.pdfS1516-4446201300030027910.1590/1516-4446-2012-0922Objective: Functional neuroimaging techniques represent fundamental tools in the context of translational research integrating neurobiology, psychopathology, neuropsychology, and therapeutics. In addition, cognitive-behavioral therapy (CBT) has proven its efficacy in the treatment of anxiety disorders and may be useful in phobias. The literature has shown that feelings and behaviors are mediated by specific brain circuits, and changes in patterns of interaction should be associated with cerebral alterations. Based on these concepts, a systematic review was conducted aiming to evaluate the impact of CBT on phobic disorders measured by functional neuroimaging techniques. Methods: A systematic review of the literature was conducted including studies published between January 1980 and April 2012. Studies written in English, Spanish or Portuguese evaluating changes in the pattern of functional neuroimaging before and after CBT in patients with phobic disorders were included. Results: The initial search strategy retrieved 45 studies. Six of these studies met all inclusion criteria. Significant deactivations in the amygdala, insula, thalamus and hippocampus, as well as activation of the medial orbitofrontal cortex, were observed after CBT in phobic patients when compared with controls. Conclusion: In spite of their technical limitations, neuroimaging techniques provide neurobiological support for the efficacy of CBT in the treatment of phobic disorders. Further studies are needed to confirm this conclusion.Universidade Federal da Bahia School of Medicine Department of Neurosciences and Mental HealthUniversidade Federal de São Paulo (UNIFESP) Department of Psychiatry Interdisciplinary Laboratory of Clinical NeurosciencesFaculdade de Medicina de São José do Rio Preto Department of Psychiatry and Medical PsychologyUniversidade de São Paulo School of Medicine Department of Neuroscience and Behavior and National Science and Technology Institute for Translational MedicineKing's College London Institute of Psychiatry Department of Psychosis StudiesUFBA Medical School Department of Imaging DiagnosisUNIFESP, Department of Psychiatry Interdisciplinary Laboratory of Clinical NeurosciencesSciELO279-283engAssociação Brasileira de Psiquiatria - ABPRevista Brasileira de PsiquiatriaPhobiacognitive therapyfunctional magnetic resonance imagingpositron-emission tomographyThe impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1516-44462013000300279.pdfapplication/pdf164507${dspace.ui.url}/bitstream/11600/7914/1/S1516-44462013000300279.pdfdbb0a760880d9177e10f03395172095cMD51open accessTEXTS1516-44462013000300279.pdf.txtS1516-44462013000300279.pdf.txtExtracted texttext/plain22455${dspace.ui.url}/bitstream/11600/7914/2/S1516-44462013000300279.pdf.txt4821c9eff055886ef9af3fce068bbc20MD52open access11600/79142021-10-05 21:53:32.001open accessoai:repositorio.unifesp.br:11600/7914Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:08:34.941329Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review |
title |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review |
spellingShingle |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] Phobia cognitive therapy functional magnetic resonance imaging positron-emission tomography |
title_short |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review |
title_full |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review |
title_fullStr |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review |
title_full_unstemmed |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review |
title_sort |
The impacts of cognitive-behavioral therapy on the treatment of phobic disorders measured by functional neuroimaging techniques: a systematic review |
author |
Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] |
author_facet |
Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Berberian, Arthur de Almeida [UNIFESP] Trezsniak, Clarissa Nery-Fernandes, Fabiana Araujo Neto, Cesar Augusto Jackowski, Andrea Parolin [UNIFESP] Miranda-Scippa, Ângela Marisa de Aquino [UNIFESP] Oliveira, Irismar Reis de |
author_role |
author |
author2 |
Araujo Filho, Gerardo Maria de [UNIFESP] Berberian, Arthur de Almeida [UNIFESP] Trezsniak, Clarissa Nery-Fernandes, Fabiana Araujo Neto, Cesar Augusto Jackowski, Andrea Parolin [UNIFESP] Miranda-Scippa, Ângela Marisa de Aquino [UNIFESP] Oliveira, Irismar Reis de |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal da Bahia School of Medicine Department of Neurosciences and Mental Health Universidade Federal de São Paulo (UNIFESP) Faculdade de Medicina de São José do Rio Preto Department of Psychiatry and Medical Psychology Universidade de São Paulo (USP) King's College London Institute of Psychiatry Department of Psychosis Studies UFBA Medical School Department of Imaging Diagnosis |
dc.contributor.author.fl_str_mv |
Almeida, Amanda Cristina Galvão Oliveira de [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Berberian, Arthur de Almeida [UNIFESP] Trezsniak, Clarissa Nery-Fernandes, Fabiana Araujo Neto, Cesar Augusto Jackowski, Andrea Parolin [UNIFESP] Miranda-Scippa, Ângela Marisa de Aquino [UNIFESP] Oliveira, Irismar Reis de |
dc.subject.eng.fl_str_mv |
Phobia cognitive therapy functional magnetic resonance imaging positron-emission tomography |
topic |
Phobia cognitive therapy functional magnetic resonance imaging positron-emission tomography |
description |
Objective: Functional neuroimaging techniques represent fundamental tools in the context of translational research integrating neurobiology, psychopathology, neuropsychology, and therapeutics. In addition, cognitive-behavioral therapy (CBT) has proven its efficacy in the treatment of anxiety disorders and may be useful in phobias. The literature has shown that feelings and behaviors are mediated by specific brain circuits, and changes in patterns of interaction should be associated with cerebral alterations. Based on these concepts, a systematic review was conducted aiming to evaluate the impact of CBT on phobic disorders measured by functional neuroimaging techniques. Methods: A systematic review of the literature was conducted including studies published between January 1980 and April 2012. Studies written in English, Spanish or Portuguese evaluating changes in the pattern of functional neuroimaging before and after CBT in patients with phobic disorders were included. Results: The initial search strategy retrieved 45 studies. Six of these studies met all inclusion criteria. Significant deactivations in the amygdala, insula, thalamus and hippocampus, as well as activation of the medial orbitofrontal cortex, were observed after CBT in phobic patients when compared with controls. Conclusion: In spite of their technical limitations, neuroimaging techniques provide neurobiological support for the efficacy of CBT in the treatment of phobic disorders. Further studies are needed to confirm this conclusion. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-09-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:45:35Z |
dc.date.available.fl_str_mv |
2015-06-14T13:45:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 3, p. 279-283, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/7914 http://dx.doi.org/10.1590/1516-4446-2012-0922 |
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1516-4446 |
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S1516-44462013000300279.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1516-44462013000300279 |
dc.identifier.doi.none.fl_str_mv |
10.1590/1516-4446-2012-0922 |
identifier_str_mv |
Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 3, p. 279-283, 2013. 1516-4446 S1516-44462013000300279.pdf S1516-44462013000300279 10.1590/1516-4446-2012-0922 |
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http://repositorio.unifesp.br/handle/11600/7914 http://dx.doi.org/10.1590/1516-4446-2012-0922 |
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279-283 |
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Associação Brasileira de Psiquiatria - ABP |
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Associação Brasileira de Psiquiatria - ABP |
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