The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study

Detalhes bibliográficos
Autor(a) principal: Hernandes, Fabiana Rodrigues [UNIFESP]
Data de Publicação: 2017
Outros Autores: Fernandes Canziani, Maria Eugenia [UNIFESP], Barreto, Fellype Carvalho [UNIFESP], Santos, Rodrigo Oliveira [UNIFESP], Moreira, Valeria de Melo, Rochitte, Carlos Eduardo, Carvalho, Aluizio Barbosa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/54724
http://dx.doi.org/10.1371/journal.pone.0174811
Resumo: Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential consequence on the progression of VC in hemodialysis patients. In this prospective study, 19 hemodialysis patients with severe secondary hyperparathyroidism (sHPT) were evaluated. All patients underwent laboratorial tests and coronary tomography at baseline and, 6 and 12 months after PTX
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spelling Hernandes, Fabiana Rodrigues [UNIFESP]Fernandes Canziani, Maria Eugenia [UNIFESP]Barreto, Fellype Carvalho [UNIFESP]Santos, Rodrigo Oliveira [UNIFESP]Moreira, Valeria de MeloRochitte, Carlos EduardoCarvalho, Aluizio Barbosa2020-07-17T14:02:17Z2020-07-17T14:02:17Z2017Plos One. San Francisco, v. 12, n. 4, p. -, 2017.1932-6203https://repositorio.unifesp.br/handle/11600/54724http://dx.doi.org/10.1371/journal.pone.0174811WOS000399371900040.pdf10.1371/journal.pone.0174811WOS:000399371900040Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential consequence on the progression of VC in hemodialysis patients. In this prospective study, 19 hemodialysis patients with severe secondary hyperparathyroidism (sHPT) were evaluated. All patients underwent laboratorial tests and coronary tomography at baseline and, 6 and 12 months after PTXbone biopsy was performed at baseline and 12-month. At baseline, all patients had increased PTH levels up to 2500 pg/mL and high turnover bone disease in their bone biopsies. Fourteen (74%) patients had VC. During the follow-up, there was a significant decrease of PTH at 6 and 12-month. At 12-month, 90% of the patients evolved to low turnover bone disease. During the period of the hungry bone syndrome (first 6 months), no change of coronary calcium score was observed. However, calcium score increased significantly thereafter (12(th) month). There was an association between VC progression and the severity of low turnover bone disease. In conclusion, the shift from high to low turnover bone disease after PTX occurs in parallel to VC progression, contributing to the understanding of the complex pathophysiology involving mineral metabolism and cardiovascular disease in hemodialysis patients.National Counsel of Technological and Scientific Development (CNPq)Univ Fed Sao Paulo, Nephrol Div, Sao Paulo, BrazilUniv Fed Parana, Nephrol Div, Curitiba, Parana, BrazilUniv Fed Sao Paulo, Head & Neck Surg Div, Sao Paulo, BrazilUniv Sao Paulo, Cardiol Div, Sao Paulo, BrazilUniv Fed Sao Paulo, Nephrol Div, Sao Paulo, BrazilWeb of Science-engPublic Library SciencePlos OneThe shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSan Francisco124info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000399371900040.pdfapplication/pdf984066${dspace.ui.url}/bitstream/11600/54724/1/WOS000399371900040.pdf2895391fcc6403f176139153cba0514cMD51open accessTEXTWOS000399371900040.pdf.txtWOS000399371900040.pdf.txtExtracted texttext/plain31834${dspace.ui.url}/bitstream/11600/54724/2/WOS000399371900040.pdf.txtaa9ca4c93d7d5578d7929a51bf69d69eMD52open accessTHUMBNAILWOS000399371900040.pdf.jpgWOS000399371900040.pdf.jpgIM Thumbnailimage/jpeg7662${dspace.ui.url}/bitstream/11600/54724/4/WOS000399371900040.pdf.jpg4aa7a35d71c7b0d1fad96753ae3c4036MD54open access11600/547242022-08-01 06:01:33.515open accessoai:repositorio.unifesp.br:11600/54724Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:13:24.518913Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
title The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
spellingShingle The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
Hernandes, Fabiana Rodrigues [UNIFESP]
title_short The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
title_full The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
title_fullStr The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
title_full_unstemmed The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
title_sort The shift from high to low turnover bone disease after parathyroidectomy is associated with the progression of vascular calcification in hemodialysis patients: A 12-month follow-up study
author Hernandes, Fabiana Rodrigues [UNIFESP]
author_facet Hernandes, Fabiana Rodrigues [UNIFESP]
Fernandes Canziani, Maria Eugenia [UNIFESP]
Barreto, Fellype Carvalho [UNIFESP]
Santos, Rodrigo Oliveira [UNIFESP]
Moreira, Valeria de Melo
Rochitte, Carlos Eduardo
Carvalho, Aluizio Barbosa
author_role author
author2 Fernandes Canziani, Maria Eugenia [UNIFESP]
Barreto, Fellype Carvalho [UNIFESP]
Santos, Rodrigo Oliveira [UNIFESP]
Moreira, Valeria de Melo
Rochitte, Carlos Eduardo
Carvalho, Aluizio Barbosa
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Hernandes, Fabiana Rodrigues [UNIFESP]
Fernandes Canziani, Maria Eugenia [UNIFESP]
Barreto, Fellype Carvalho [UNIFESP]
Santos, Rodrigo Oliveira [UNIFESP]
Moreira, Valeria de Melo
Rochitte, Carlos Eduardo
Carvalho, Aluizio Barbosa
description Parathyroidectomy (PTX) may cause low levels of PTH, leading to an excessive reduction of bone turnover, which is associated with poor outcomes in dialysis patients, including vascular calcification (VC). We aimed to prospectively investigate the impact of PTX on bone remodeling and its potential consequence on the progression of VC in hemodialysis patients. In this prospective study, 19 hemodialysis patients with severe secondary hyperparathyroidism (sHPT) were evaluated. All patients underwent laboratorial tests and coronary tomography at baseline and, 6 and 12 months after PTX
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2020-07-17T14:02:17Z
dc.date.available.fl_str_mv 2020-07-17T14:02:17Z
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dc.identifier.citation.fl_str_mv Plos One. San Francisco, v. 12, n. 4, p. -, 2017.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/54724
http://dx.doi.org/10.1371/journal.pone.0174811
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.file.none.fl_str_mv WOS000399371900040.pdf
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0174811
dc.identifier.wos.none.fl_str_mv WOS:000399371900040
identifier_str_mv Plos One. San Francisco, v. 12, n. 4, p. -, 2017.
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WOS000399371900040.pdf
10.1371/journal.pone.0174811
WOS:000399371900040
url https://repositorio.unifesp.br/handle/11600/54724
http://dx.doi.org/10.1371/journal.pone.0174811
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dc.publisher.none.fl_str_mv Public Library Science
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instname:Universidade Federal de São Paulo (UNIFESP)
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