Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women

Detalhes bibliográficos
Autor(a) principal: Tomaz, Paulo Roberto Xavier
Data de Publicação: 2018
Outros Autores: Santos, Juliana Rocha, Scholz, Jaqueline, Abe, Tania Ogawa, Gaya, Patricia Viviane, Negrao, Andre Brooking, Krieger, Jose Eduardo, Pereira, Alexandre Costa, Santos, Paulo Caleb Junior Lima [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/55642
http://dx.doi.org/10.1186/s12881-018-0571-3
Resumo: Background: The identification of variants in the nicotinic acetylcholine receptor (nAChR) subunit genes associated with smoking phenotypes are increasingly important for prevention and treatment of nicotine dependence. In the context of personalized medicine, the aims of this study were to evaluate whether cholinergic receptor nicotinic alpha 2 (CHRNA2), cholinergic receptor nicotinic alpha 3 (CHRNA3), cholinergic receptor nicotinic alpha 5 (CHRNA5) and cholinergic receptor nicotinic beta 3 (CHRNB3) polymorphisms were associated with nicotine dependence severity, and to investigate possible pharmacogenetics markers of smoking cessation treatment. Methods: This study cohort enrolled 1049 smoking patients who received pharmacological treatment (varenicline, varenicline plus bupropion, bupropion plus/or nicotine replacement therapy). Smoking cessation success was considered for patients who completed 6 months of continuous abstinence. Fagerstrom test for nicotine dependence (FTND) and Issa situational smoking scores (Issa score) were analyzed for nicotine dependence. CHRNA2 (rs2472553), CHRNA3 (rs1051730), CHRNA5 (rs16969968 and rs2036527) and CHRNB3 (rs6474413) polymorphisms were genotyped by high resolution melting analysis. Results: Females with GA and AA genotypes for CHRNA5 rs16969968 and rs2036527 polymorphisms had higher success rate in smoking cessation treatment: 44.0% and 56.3% (rs16969968), 41.5% and 56.5% (rs2036527), respectively, compared with carriers of the GG genotypes: 35.7% (rs16969968), 34.8% (rs2036527), (P = 0.03, n = 389
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spelling Tomaz, Paulo Roberto XavierSantos, Juliana RochaScholz, JaquelineAbe, Tania OgawaGaya, Patricia VivianeNegrao, Andre BrookingKrieger, Jose EduardoPereira, Alexandre CostaSantos, Paulo Caleb Junior Lima [UNIFESP]2020-07-20T16:31:01Z2020-07-20T16:31:01Z2018Bmc Medical Genetics. London, v. 19, p. -, 2018.1471-2350https://repositorio.unifesp.br/handle/11600/55642http://dx.doi.org/10.1186/s12881-018-0571-3WOS000429568100001.pdf10.1186/s12881-018-0571-3WOS:000429568100001Background: The identification of variants in the nicotinic acetylcholine receptor (nAChR) subunit genes associated with smoking phenotypes are increasingly important for prevention and treatment of nicotine dependence. In the context of personalized medicine, the aims of this study were to evaluate whether cholinergic receptor nicotinic alpha 2 (CHRNA2), cholinergic receptor nicotinic alpha 3 (CHRNA3), cholinergic receptor nicotinic alpha 5 (CHRNA5) and cholinergic receptor nicotinic beta 3 (CHRNB3) polymorphisms were associated with nicotine dependence severity, and to investigate possible pharmacogenetics markers of smoking cessation treatment. Methods: This study cohort enrolled 1049 smoking patients who received pharmacological treatment (varenicline, varenicline plus bupropion, bupropion plus/or nicotine replacement therapy). Smoking cessation success was considered for patients who completed 6 months of continuous abstinence. Fagerstrom test for nicotine dependence (FTND) and Issa situational smoking scores (Issa score) were analyzed for nicotine dependence. CHRNA2 (rs2472553), CHRNA3 (rs1051730), CHRNA5 (rs16969968 and rs2036527) and CHRNB3 (rs6474413) polymorphisms were genotyped by high resolution melting analysis. Results: Females with GA and AA genotypes for CHRNA5 rs16969968 and rs2036527 polymorphisms had higher success rate in smoking cessation treatment: 44.0% and 56.3% (rs16969968), 41.5% and 56.5% (rs2036527), respectively, compared with carriers of the GG genotypes: 35.7% (rs16969968), 34.8% (rs2036527), (P = 0.03, n = 389P = 0.01, n = 391). The GA or AA genotypes for the rs16969968 and rs2036527 were associated with higher odds ratio for success in women (OR = 1.6395% CI = 1.04 to 2.54P = 0.03 and OR = 1.59, 95% CI = 1.02 to 2.48P = 0.04respectively). We did not find association of these polymorphisms with nicotine dependence related scores. Polymorphisms in the CHRNA2, CHRNA3 and CHRNB3 genes were not associated with the phenotypes studied. Conclusion: CHRNA5 rs16969968 and rs2036527 were associated with higher success rate in the smoking cessation treatment in women. These findings might contribute to advances in personalized medicine.FAPESPCNPq, BrazilCAPES, BrazilUniv Sao Paulo, Hosp Clin, Fac Med, Inst Coracao InCor,Lab Genet & Mol Cardiol, Sao Paulo, SP, BrazilUniv Sao Paulo, Hosp Clin, Fac Med, Inst Coracao InCor,Smoking Cessat Program Dept, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, SP, BrazilFAPESP: 2013-09295-3FAPESP: 2013-20614-3CNPq: 470410/2013-2CNPq: 167587/2013-7Web of Science-engBiomed Central LtdBmc Medical GeneticsCHRNA5Nicotine dependenceSmoking cessationPolymorphismCholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondonv. 19info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000429568100001.pdfapplication/pdf415523${dspace.ui.url}/bitstream/11600/55642/1/WOS000429568100001.pdfc2fd9a8c834b864ced46ca438f225983MD51open accessTEXTWOS000429568100001.pdf.txtWOS000429568100001.pdf.txtExtracted texttext/plain43578${dspace.ui.url}/bitstream/11600/55642/2/WOS000429568100001.pdf.txt7be389c6e905590ea184a213bf18fe3fMD52open accessTHUMBNAILWOS000429568100001.pdf.jpgWOS000429568100001.pdf.jpgIM Thumbnailimage/jpeg6498${dspace.ui.url}/bitstream/11600/55642/4/WOS000429568100001.pdf.jpg6cfec59da92b0bf012466d957e4c72cdMD54open access11600/556422022-08-01 02:42:50.292open accessoai:repositorio.unifesp.br:11600/55642Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:07:34.496534Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
title Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
spellingShingle Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
Tomaz, Paulo Roberto Xavier
CHRNA5
Nicotine dependence
Smoking cessation
Polymorphism
title_short Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
title_full Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
title_fullStr Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
title_full_unstemmed Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
title_sort Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women
author Tomaz, Paulo Roberto Xavier
author_facet Tomaz, Paulo Roberto Xavier
Santos, Juliana Rocha
Scholz, Jaqueline
Abe, Tania Ogawa
Gaya, Patricia Viviane
Negrao, Andre Brooking
Krieger, Jose Eduardo
Pereira, Alexandre Costa
Santos, Paulo Caleb Junior Lima [UNIFESP]
author_role author
author2 Santos, Juliana Rocha
Scholz, Jaqueline
Abe, Tania Ogawa
Gaya, Patricia Viviane
Negrao, Andre Brooking
Krieger, Jose Eduardo
Pereira, Alexandre Costa
Santos, Paulo Caleb Junior Lima [UNIFESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tomaz, Paulo Roberto Xavier
Santos, Juliana Rocha
Scholz, Jaqueline
Abe, Tania Ogawa
Gaya, Patricia Viviane
Negrao, Andre Brooking
Krieger, Jose Eduardo
Pereira, Alexandre Costa
Santos, Paulo Caleb Junior Lima [UNIFESP]
dc.subject.eng.fl_str_mv CHRNA5
Nicotine dependence
Smoking cessation
Polymorphism
topic CHRNA5
Nicotine dependence
Smoking cessation
Polymorphism
description Background: The identification of variants in the nicotinic acetylcholine receptor (nAChR) subunit genes associated with smoking phenotypes are increasingly important for prevention and treatment of nicotine dependence. In the context of personalized medicine, the aims of this study were to evaluate whether cholinergic receptor nicotinic alpha 2 (CHRNA2), cholinergic receptor nicotinic alpha 3 (CHRNA3), cholinergic receptor nicotinic alpha 5 (CHRNA5) and cholinergic receptor nicotinic beta 3 (CHRNB3) polymorphisms were associated with nicotine dependence severity, and to investigate possible pharmacogenetics markers of smoking cessation treatment. Methods: This study cohort enrolled 1049 smoking patients who received pharmacological treatment (varenicline, varenicline plus bupropion, bupropion plus/or nicotine replacement therapy). Smoking cessation success was considered for patients who completed 6 months of continuous abstinence. Fagerstrom test for nicotine dependence (FTND) and Issa situational smoking scores (Issa score) were analyzed for nicotine dependence. CHRNA2 (rs2472553), CHRNA3 (rs1051730), CHRNA5 (rs16969968 and rs2036527) and CHRNB3 (rs6474413) polymorphisms were genotyped by high resolution melting analysis. Results: Females with GA and AA genotypes for CHRNA5 rs16969968 and rs2036527 polymorphisms had higher success rate in smoking cessation treatment: 44.0% and 56.3% (rs16969968), 41.5% and 56.5% (rs2036527), respectively, compared with carriers of the GG genotypes: 35.7% (rs16969968), 34.8% (rs2036527), (P = 0.03, n = 389
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2020-07-20T16:31:01Z
dc.date.available.fl_str_mv 2020-07-20T16:31:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv Bmc Medical Genetics. London, v. 19, p. -, 2018.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/55642
http://dx.doi.org/10.1186/s12881-018-0571-3
dc.identifier.issn.none.fl_str_mv 1471-2350
dc.identifier.file.none.fl_str_mv WOS000429568100001.pdf
dc.identifier.doi.none.fl_str_mv 10.1186/s12881-018-0571-3
dc.identifier.wos.none.fl_str_mv WOS:000429568100001
identifier_str_mv Bmc Medical Genetics. London, v. 19, p. -, 2018.
1471-2350
WOS000429568100001.pdf
10.1186/s12881-018-0571-3
WOS:000429568100001
url https://repositorio.unifesp.br/handle/11600/55642
http://dx.doi.org/10.1186/s12881-018-0571-3
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Bmc Medical Genetics
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dc.coverage.none.fl_str_mv London
dc.publisher.none.fl_str_mv Biomed Central Ltd
publisher.none.fl_str_mv Biomed Central Ltd
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instname:Universidade Federal de São Paulo (UNIFESP)
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