Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/55502 http://dx.doi.org/10.1155/2017/8429290 |
Resumo: | Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25mg/kg, i.p.). Catalepsy, open field, oralmovements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD. |
id |
UFSP_43bca36dd8727739d7ed51ab71420f6d |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/55502 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Mateus Brandao, Luiz EduardoMorais Ferreira Noga, Diana AlineDierschnabel, Aline Limadas Chagas Campelo, Clarissa LoureiroRodrigues Meurer, Ywlliane da SilvaLima, Ramon HypolitoGalvao Januario Engelberth, Rovena ClaraCavalcante, Jeferson SouzaLima, Clesio AndradeMarchioro, MuriloEstevam, Charles dos SantosSantos, Jose RonaldoSilva, Regina Helena [UNIFESP]Ribeiro, Alessandra Mussi [UNIFESP]2020-07-17T14:03:34Z2020-07-17T14:03:34Z2017Evidence-Based Complementary And Alternative Medicine. London, v. , p. -, 2017.1741-427Xhttps://repositorio.unifesp.br/handle/11600/55502http://dx.doi.org/10.1155/2017/8429290WOS000407322700001.pdf10.1155/2017/8429290WOS:000407322700001Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25mg/kg, i.p.). Catalepsy, open field, oralmovements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Pro-Reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN)Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN/MCT/CNPq/CT-INFRA Grant)Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP)Univ Fed Rio Grande do Norte, Natal, RN, BrazilUniv Fed Sergipe, Sao Cristovao, BrazilUniv Fed Sao Paulo, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Santos, SP, BrazilUniv Fed Sao Paulo, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Santos, SP, BrazilCNPq: 480115/2010-9FAPERN/MCT/CNPq/CT-INFRA Grant: 013/2009FAPESP: 2015/03354-3Web of Science-engHindawi LtdEvidence-Based Complementary And Alternative MedicinePassiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondoninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000407322700001.pdfapplication/pdf2857647${dspace.ui.url}/bitstream/11600/55502/1/WOS000407322700001.pdfd570d4ee90a3053a6016e5eb6930234fMD51open accessTEXTWOS000407322700001.pdf.txtWOS000407322700001.pdf.txtExtracted texttext/plain55736${dspace.ui.url}/bitstream/11600/55502/5/WOS000407322700001.pdf.txt87d3dc4bcebc63e9e4637518e953b76bMD55open accessTHUMBNAILWOS000407322700001.pdf.jpgWOS000407322700001.pdf.jpgIM Thumbnailimage/jpeg6527${dspace.ui.url}/bitstream/11600/55502/7/WOS000407322700001.pdf.jpga04ebccd9a18cc9a46042e5f4657a7baMD57open access11600/555022023-06-05 19:05:57.375open accessoai:repositorio.unifesp.br:11600/55502Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:05:57Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease |
title |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease |
spellingShingle |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease Mateus Brandao, Luiz Eduardo |
title_short |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease |
title_full |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease |
title_fullStr |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease |
title_full_unstemmed |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease |
title_sort |
Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson's Disease |
author |
Mateus Brandao, Luiz Eduardo |
author_facet |
Mateus Brandao, Luiz Eduardo Morais Ferreira Noga, Diana Aline Dierschnabel, Aline Lima das Chagas Campelo, Clarissa Loureiro Rodrigues Meurer, Ywlliane da Silva Lima, Ramon Hypolito Galvao Januario Engelberth, Rovena Clara Cavalcante, Jeferson Souza Lima, Clesio Andrade Marchioro, Murilo Estevam, Charles dos Santos Santos, Jose Ronaldo Silva, Regina Helena [UNIFESP] Ribeiro, Alessandra Mussi [UNIFESP] |
author_role |
author |
author2 |
Morais Ferreira Noga, Diana Aline Dierschnabel, Aline Lima das Chagas Campelo, Clarissa Loureiro Rodrigues Meurer, Ywlliane da Silva Lima, Ramon Hypolito Galvao Januario Engelberth, Rovena Clara Cavalcante, Jeferson Souza Lima, Clesio Andrade Marchioro, Murilo Estevam, Charles dos Santos Santos, Jose Ronaldo Silva, Regina Helena [UNIFESP] Ribeiro, Alessandra Mussi [UNIFESP] |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Mateus Brandao, Luiz Eduardo Morais Ferreira Noga, Diana Aline Dierschnabel, Aline Lima das Chagas Campelo, Clarissa Loureiro Rodrigues Meurer, Ywlliane da Silva Lima, Ramon Hypolito Galvao Januario Engelberth, Rovena Clara Cavalcante, Jeferson Souza Lima, Clesio Andrade Marchioro, Murilo Estevam, Charles dos Santos Santos, Jose Ronaldo Silva, Regina Helena [UNIFESP] Ribeiro, Alessandra Mussi [UNIFESP] |
description |
Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson's disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25mg/kg, i.p.). Catalepsy, open field, oralmovements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-17T14:03:34Z |
dc.date.available.fl_str_mv |
2020-07-17T14:03:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Evidence-Based Complementary And Alternative Medicine. London, v. , p. -, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/55502 http://dx.doi.org/10.1155/2017/8429290 |
dc.identifier.issn.none.fl_str_mv |
1741-427X |
dc.identifier.file.none.fl_str_mv |
WOS000407322700001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1155/2017/8429290 |
dc.identifier.wos.none.fl_str_mv |
WOS:000407322700001 |
identifier_str_mv |
Evidence-Based Complementary And Alternative Medicine. London, v. , p. -, 2017. 1741-427X WOS000407322700001.pdf 10.1155/2017/8429290 WOS:000407322700001 |
url |
https://repositorio.unifesp.br/handle/11600/55502 http://dx.doi.org/10.1155/2017/8429290 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Evidence-Based Complementary And Alternative Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- |
dc.coverage.none.fl_str_mv |
London |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/55502/1/WOS000407322700001.pdf ${dspace.ui.url}/bitstream/11600/55502/5/WOS000407322700001.pdf.txt ${dspace.ui.url}/bitstream/11600/55502/7/WOS000407322700001.pdf.jpg |
bitstream.checksum.fl_str_mv |
d570d4ee90a3053a6016e5eb6930234f 87d3dc4bcebc63e9e4637518e953b76b a04ebccd9a18cc9a46042e5f4657a7ba |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460254165499904 |