Jucara pulp supplementation improves glucose tolerance in mice
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/58542 https://doi.org/10.1186/s13098-015-0122-4 |
Resumo: | Background: The consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Jucara (Euterpe edulis Mart), could be a tool to prevent the deleterious effect of high white adipose deposition. The aim of the present study was to evaluate the effect of administration of jucara pulp in mice fed a high-fat, high-calorie diet on glucose tolerance and adipose tissue inflammatory status. Methods: Mice were distributed into the following groups: control diet; control diet plus 0.5 % of jucara; control diet plus 2 % of jucara; hypercaloric and hyperlipidic diet; hypercaloric and hyperlipidic diet plus 0.5 % of jucara and hypercaloric and hyperlipidic diet plus 2 % of jucara. Treatments started when mice were 8 weeks old and carried on for a total period of 10 weeks. The serum glucose, triacylglycerol, total cholesterol, insulin, adiponectin, lipopolysaccharides and free fatty acids concentrations were measured. Oral glucose tolerance test was performed. TNF-alpha, IL-6, and IL-10 protein level were determined by ELISA on mesenteric and epididymal white adipose tissues. Determination of catalase activity was realized in the same tissues. Data were analysed using one-way analysis of variance and post hoc analysis was performed with the Tukey's test. Results: The addition of 0.5 % jucara improved glycemic response in animals that consumed normocaloric as well as hypercaloric and hyperlipidic diets (HC). Supplementation with 0.5 and 2 % did not change the body composition of animals that received the HC diet; however, the animals fed the normocaloric diet with 2 % jucara gained body mass. An intake of 2 % jucara in the HC diet promoted a reduction of catalase activity and IL-10 level in epididymal adipose tissue. Conclusions: These results suggest that with the administration of 0.5 % jucara, the beneficial effects of polyphenols overcome the deleterious effects of macronutrient composition of jucara, whereas with the administration of 2 % jucara promotes damage by the composition of the fruit and overshadows the beneficial effects of polyphenols on glucose metabolism. On the other hand, higher jucara supplementation improves the inflammatory status targeted by the HC diet. |
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Oyama, Lila Missae [UNIFESP]Silva, Fernanda Pinheiro da [UNIFESP]Carnier, June [UNIFESP]Miranda, Danielle Araujo de [UNIFESP]Santamarina, Aline Boveto [UNIFESP]Ribeiro, Eliane Beraldi [UNIFESP]Nascimento, Claudia Maria da Penha Oller do [UNIFESP]Rosso, Veridiana Vera de [UNIFESP]2020-10-30T18:46:38Z2020-10-30T18:46:38Z2016Diabetology & Metabolic Syndrome. London, v. 8, p. -, 2016.1758-5996https://repositorio.unifesp.br/handle/11600/58542https://doi.org/10.1186/s13098-015-0122-4WOS000368572700002.pdf10.1186/s13098-015-0122-4WOS:000368572700002Background: The consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Jucara (Euterpe edulis Mart), could be a tool to prevent the deleterious effect of high white adipose deposition. The aim of the present study was to evaluate the effect of administration of jucara pulp in mice fed a high-fat, high-calorie diet on glucose tolerance and adipose tissue inflammatory status. Methods: Mice were distributed into the following groups: control diet; control diet plus 0.5 % of jucara; control diet plus 2 % of jucara; hypercaloric and hyperlipidic diet; hypercaloric and hyperlipidic diet plus 0.5 % of jucara and hypercaloric and hyperlipidic diet plus 2 % of jucara. Treatments started when mice were 8 weeks old and carried on for a total period of 10 weeks. The serum glucose, triacylglycerol, total cholesterol, insulin, adiponectin, lipopolysaccharides and free fatty acids concentrations were measured. Oral glucose tolerance test was performed. TNF-alpha, IL-6, and IL-10 protein level were determined by ELISA on mesenteric and epididymal white adipose tissues. Determination of catalase activity was realized in the same tissues. Data were analysed using one-way analysis of variance and post hoc analysis was performed with the Tukey's test. Results: The addition of 0.5 % jucara improved glycemic response in animals that consumed normocaloric as well as hypercaloric and hyperlipidic diets (HC). Supplementation with 0.5 and 2 % did not change the body composition of animals that received the HC diet; however, the animals fed the normocaloric diet with 2 % jucara gained body mass. An intake of 2 % jucara in the HC diet promoted a reduction of catalase activity and IL-10 level in epididymal adipose tissue. Conclusions: These results suggest that with the administration of 0.5 % jucara, the beneficial effects of polyphenols overcome the deleterious effects of macronutrient composition of jucara, whereas with the administration of 2 % jucara promotes damage by the composition of the fruit and overshadows the beneficial effects of polyphenols on glucose metabolism. On the other hand, higher jucara supplementation improves the inflammatory status targeted by the HC diet.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Rua Botucatu,862 Vila Clementino, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Fisiol, Rua Botucatu,862 Vila Clementino, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Inst Saude & Soc, Dept Biociencias, Sao Paulo, BrazilFAPESP: 2009/53884-8FAPESP: 2013/12325-1Web of Science-engBiomed Central LtdDiabetology & Metabolic SyndromeJucaraEuterpe edulis MartObesityInflammationMiceAnthocyaninsJucara pulp supplementation improves glucose tolerance in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondon8info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000368572700002.pdfapplication/pdf1032174${dspace.ui.url}/bitstream/11600/58542/1/WOS000368572700002.pdf350d1f119a8343c15826afdf82b61153MD51open accessTEXTWOS000368572700002.pdf.txtWOS000368572700002.pdf.txtExtracted texttext/plain38018${dspace.ui.url}/bitstream/11600/58542/5/WOS000368572700002.pdf.txtb601fbd4c4899b5af70fcea99c87e186MD55open accessTHUMBNAILWOS000368572700002.pdf.jpgWOS000368572700002.pdf.jpgIM Thumbnailimage/jpeg6994${dspace.ui.url}/bitstream/11600/58542/7/WOS000368572700002.pdf.jpgfdbf0f1bd08a7a489468062c8c0690b3MD57open access11600/585422023-06-05 19:13:05.03open accessoai:repositorio.unifesp.br:11600/58542Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:13:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Jucara pulp supplementation improves glucose tolerance in mice |
title |
Jucara pulp supplementation improves glucose tolerance in mice |
spellingShingle |
Jucara pulp supplementation improves glucose tolerance in mice Oyama, Lila Missae [UNIFESP] Jucara Euterpe edulis Mart Obesity Inflammation Mice Anthocyanins |
title_short |
Jucara pulp supplementation improves glucose tolerance in mice |
title_full |
Jucara pulp supplementation improves glucose tolerance in mice |
title_fullStr |
Jucara pulp supplementation improves glucose tolerance in mice |
title_full_unstemmed |
Jucara pulp supplementation improves glucose tolerance in mice |
title_sort |
Jucara pulp supplementation improves glucose tolerance in mice |
author |
Oyama, Lila Missae [UNIFESP] |
author_facet |
Oyama, Lila Missae [UNIFESP] Silva, Fernanda Pinheiro da [UNIFESP] Carnier, June [UNIFESP] Miranda, Danielle Araujo de [UNIFESP] Santamarina, Aline Boveto [UNIFESP] Ribeiro, Eliane Beraldi [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Rosso, Veridiana Vera de [UNIFESP] |
author_role |
author |
author2 |
Silva, Fernanda Pinheiro da [UNIFESP] Carnier, June [UNIFESP] Miranda, Danielle Araujo de [UNIFESP] Santamarina, Aline Boveto [UNIFESP] Ribeiro, Eliane Beraldi [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Rosso, Veridiana Vera de [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Oyama, Lila Missae [UNIFESP] Silva, Fernanda Pinheiro da [UNIFESP] Carnier, June [UNIFESP] Miranda, Danielle Araujo de [UNIFESP] Santamarina, Aline Boveto [UNIFESP] Ribeiro, Eliane Beraldi [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Rosso, Veridiana Vera de [UNIFESP] |
dc.subject.eng.fl_str_mv |
Jucara Euterpe edulis Mart Obesity Inflammation Mice Anthocyanins |
topic |
Jucara Euterpe edulis Mart Obesity Inflammation Mice Anthocyanins |
description |
Background: The consumption of hyperlipidic and hypercaloric diet is considered a major factor to promote obesity and the consumption of food with antioxidant properties, like Jucara (Euterpe edulis Mart), could be a tool to prevent the deleterious effect of high white adipose deposition. The aim of the present study was to evaluate the effect of administration of jucara pulp in mice fed a high-fat, high-calorie diet on glucose tolerance and adipose tissue inflammatory status. Methods: Mice were distributed into the following groups: control diet; control diet plus 0.5 % of jucara; control diet plus 2 % of jucara; hypercaloric and hyperlipidic diet; hypercaloric and hyperlipidic diet plus 0.5 % of jucara and hypercaloric and hyperlipidic diet plus 2 % of jucara. Treatments started when mice were 8 weeks old and carried on for a total period of 10 weeks. The serum glucose, triacylglycerol, total cholesterol, insulin, adiponectin, lipopolysaccharides and free fatty acids concentrations were measured. Oral glucose tolerance test was performed. TNF-alpha, IL-6, and IL-10 protein level were determined by ELISA on mesenteric and epididymal white adipose tissues. Determination of catalase activity was realized in the same tissues. Data were analysed using one-way analysis of variance and post hoc analysis was performed with the Tukey's test. Results: The addition of 0.5 % jucara improved glycemic response in animals that consumed normocaloric as well as hypercaloric and hyperlipidic diets (HC). Supplementation with 0.5 and 2 % did not change the body composition of animals that received the HC diet; however, the animals fed the normocaloric diet with 2 % jucara gained body mass. An intake of 2 % jucara in the HC diet promoted a reduction of catalase activity and IL-10 level in epididymal adipose tissue. Conclusions: These results suggest that with the administration of 0.5 % jucara, the beneficial effects of polyphenols overcome the deleterious effects of macronutrient composition of jucara, whereas with the administration of 2 % jucara promotes damage by the composition of the fruit and overshadows the beneficial effects of polyphenols on glucose metabolism. On the other hand, higher jucara supplementation improves the inflammatory status targeted by the HC diet. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-10-30T18:46:38Z |
dc.date.available.fl_str_mv |
2020-10-30T18:46:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Diabetology & Metabolic Syndrome. London, v. 8, p. -, 2016. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/58542 https://doi.org/10.1186/s13098-015-0122-4 |
dc.identifier.issn.none.fl_str_mv |
1758-5996 |
dc.identifier.file.none.fl_str_mv |
WOS000368572700002.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1186/s13098-015-0122-4 |
dc.identifier.wos.none.fl_str_mv |
WOS:000368572700002 |
identifier_str_mv |
Diabetology & Metabolic Syndrome. London, v. 8, p. -, 2016. 1758-5996 WOS000368572700002.pdf 10.1186/s13098-015-0122-4 WOS:000368572700002 |
url |
https://repositorio.unifesp.br/handle/11600/58542 https://doi.org/10.1186/s13098-015-0122-4 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.ispartof.none.fl_str_mv |
Diabetology & Metabolic Syndrome |
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openAccess |
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London |
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Biomed Central Ltd |
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Biomed Central Ltd |
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