Increased concentration of plasma homocysteine in children with systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43314 http://www.clinexprheumatol.org/article.asp?a=2968 |
Resumo: | ObjectiveStudies in adults with SLE have evidenced increase of homocysteine related, mainly, to thromboembolic events. The aim of our study was to evaluate plasma homocysteine concentration in children with systemic lupus erythematosus (SLE) and its correlation with renal involvement, serum and erythrocyte folate, vitamin B12, antiphospholipid antibodies, estimated creatinine clearance and dyslipidemia.MethodsThirty-two children (29 females) with SLE and 32 healthy controls (29 females) matched for age and sex were included in the study. The mean age of patients and controls was 14.2 years (range from 10 to 18 years). Only one patient presented one thrombotic event. Plasma homocysteine, erythrocyte and serum folate, vitamin B12, lipid profile, antiphospholipid antibodies and estimated creatinine clearance were evaluated. Raised homocysteine concentration was defined as equal or more than 12.9 mol/L.ResultsRaised homocysteine concentration was detected in 15 (46.9%) children with SLE with an important statistical difference in relation to control group (p < 0.001). A positive correlation was found between plasma homocysteine concentration and renal involvement (odds ratio 11.1 [95% CI 1.50-82.24], p = 0.01) based on the presence of renal biopsy, abnormalities of urine sediment and/or serum creatinine. However when we performed the estimated creatinine clearance the correlation with homocysteine concentration was not positive. We did not observe abnormalities in serum and erythrocyte folate and vitamin B12 in our patients. However they presented significant higher concentrations of TC total cholesterol (p = 0.005) and of LDL low-density lipoprotein (p = 0.02) than controls.ConclusionsElevated plasma homocysteine concentration is frequent in children with SLE. We believe that these results may signalize to the possibility of complications in our patients later in life. Further long-term and prospective studies are needed in order to determine the real role of the homocysteine concentration as a risk factor in children. |
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Prado, Rogério do [UNIFESP]D'Almeida, V. M.Guerra-Shinohara, E.Galdieri, Luciano de Camargo [UNIFESP]Terreri, Maria Teresa Ramos Ascensão [UNIFESP]Hilário, Maria Odete Esteves [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2018-06-15T16:52:41Z2018-06-15T16:52:41Z2006-09-01Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 24, n. 5, p. 594-598, 2006.0392-856Xhttp://repositorio.unifesp.br/11600/43314http://www.clinexprheumatol.org/article.asp?a=2968WOS:000242691600019ObjectiveStudies in adults with SLE have evidenced increase of homocysteine related, mainly, to thromboembolic events. The aim of our study was to evaluate plasma homocysteine concentration in children with systemic lupus erythematosus (SLE) and its correlation with renal involvement, serum and erythrocyte folate, vitamin B12, antiphospholipid antibodies, estimated creatinine clearance and dyslipidemia.MethodsThirty-two children (29 females) with SLE and 32 healthy controls (29 females) matched for age and sex were included in the study. The mean age of patients and controls was 14.2 years (range from 10 to 18 years). Only one patient presented one thrombotic event. Plasma homocysteine, erythrocyte and serum folate, vitamin B12, lipid profile, antiphospholipid antibodies and estimated creatinine clearance were evaluated. Raised homocysteine concentration was defined as equal or more than 12.9 mol/L.ResultsRaised homocysteine concentration was detected in 15 (46.9%) children with SLE with an important statistical difference in relation to control group (p < 0.001). A positive correlation was found between plasma homocysteine concentration and renal involvement (odds ratio 11.1 [95% CI 1.50-82.24], p = 0.01) based on the presence of renal biopsy, abnormalities of urine sediment and/or serum creatinine. However when we performed the estimated creatinine clearance the correlation with homocysteine concentration was not positive. We did not observe abnormalities in serum and erythrocyte folate and vitamin B12 in our patients. However they presented significant higher concentrations of TC total cholesterol (p = 0.005) and of LDL low-density lipoprotein (p = 0.02) than controls.ConclusionsElevated plasma homocysteine concentration is frequent in children with SLE. We believe that these results may signalize to the possibility of complications in our patients later in life. Further long-term and prospective studies are needed in order to determine the real role of the homocysteine concentration as a risk factor in children.Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, BrazilUniv Sao Paulo, Fac Pharmaceut Sci, Dept Clin Chem & Toxicol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Pediat, Sao Paulo, BrazilWeb of Science594-598engClinical & Exper RheumatologyClinical And Experimental RheumatologySystemic lupus erythematosushomocysteineChildrendyslipidemiaIncreased concentration of plasma homocysteine in children with systemic lupus erythematosusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/433142022-09-19 22:26:28.44metadata only accessoai:repositorio.unifesp.br:11600/43314Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:43:05.704924Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus |
title |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus |
spellingShingle |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus Prado, Rogério do [UNIFESP] Systemic lupus erythematosus homocysteine Children dyslipidemia |
title_short |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus |
title_full |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus |
title_fullStr |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus |
title_full_unstemmed |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus |
title_sort |
Increased concentration of plasma homocysteine in children with systemic lupus erythematosus |
author |
Prado, Rogério do [UNIFESP] |
author_facet |
Prado, Rogério do [UNIFESP] D'Almeida, V. M. Guerra-Shinohara, E. Galdieri, Luciano de Camargo [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] |
author_role |
author |
author2 |
D'Almeida, V. M. Guerra-Shinohara, E. Galdieri, Luciano de Camargo [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Prado, Rogério do [UNIFESP] D'Almeida, V. M. Guerra-Shinohara, E. Galdieri, Luciano de Camargo [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] |
dc.subject.eng.fl_str_mv |
Systemic lupus erythematosus homocysteine Children dyslipidemia |
topic |
Systemic lupus erythematosus homocysteine Children dyslipidemia |
description |
ObjectiveStudies in adults with SLE have evidenced increase of homocysteine related, mainly, to thromboembolic events. The aim of our study was to evaluate plasma homocysteine concentration in children with systemic lupus erythematosus (SLE) and its correlation with renal involvement, serum and erythrocyte folate, vitamin B12, antiphospholipid antibodies, estimated creatinine clearance and dyslipidemia.MethodsThirty-two children (29 females) with SLE and 32 healthy controls (29 females) matched for age and sex were included in the study. The mean age of patients and controls was 14.2 years (range from 10 to 18 years). Only one patient presented one thrombotic event. Plasma homocysteine, erythrocyte and serum folate, vitamin B12, lipid profile, antiphospholipid antibodies and estimated creatinine clearance were evaluated. Raised homocysteine concentration was defined as equal or more than 12.9 mol/L.ResultsRaised homocysteine concentration was detected in 15 (46.9%) children with SLE with an important statistical difference in relation to control group (p < 0.001). A positive correlation was found between plasma homocysteine concentration and renal involvement (odds ratio 11.1 [95% CI 1.50-82.24], p = 0.01) based on the presence of renal biopsy, abnormalities of urine sediment and/or serum creatinine. However when we performed the estimated creatinine clearance the correlation with homocysteine concentration was not positive. We did not observe abnormalities in serum and erythrocyte folate and vitamin B12 in our patients. However they presented significant higher concentrations of TC total cholesterol (p = 0.005) and of LDL low-density lipoprotein (p = 0.02) than controls.ConclusionsElevated plasma homocysteine concentration is frequent in children with SLE. We believe that these results may signalize to the possibility of complications in our patients later in life. Further long-term and prospective studies are needed in order to determine the real role of the homocysteine concentration as a risk factor in children. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-09-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T16:52:41Z |
dc.date.available.fl_str_mv |
2018-06-15T16:52:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 24, n. 5, p. 594-598, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43314 http://www.clinexprheumatol.org/article.asp?a=2968 |
dc.identifier.issn.none.fl_str_mv |
0392-856X |
dc.identifier.wos.none.fl_str_mv |
WOS:000242691600019 |
identifier_str_mv |
Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 24, n. 5, p. 594-598, 2006. 0392-856X WOS:000242691600019 |
url |
http://repositorio.unifesp.br/11600/43314 http://www.clinexprheumatol.org/article.asp?a=2968 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Clinical And Experimental Rheumatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
594-598 |
dc.publisher.none.fl_str_mv |
Clinical & Exper Rheumatology |
publisher.none.fl_str_mv |
Clinical & Exper Rheumatology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460330759782400 |