Effect of oral diacerein (DAR) in an experimental hip chondrolysis model
Main Author: | |
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Publication Date: | 2006 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/28913 http://dx.doi.org/10.1002/jor.20180 |
Summary: | We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin inhibitor, diacerein (DAR) in the ensuing articular cartilage lesion. Twenty immature beagles were submitted to a surgical K-wire implantation in the hip with the material left in the joint space for 6 months. Twelve animals were sacrificed for histological and biochemical tests. Eight animals were sacrificed at 10 months (half of them treated with DAR) and analyzed by scanning electron microscopy (SEM) and biochemistry of the articular cartilage. Preoperative and monthly C3 and C4 complement and immunoglobulins serum levels were determined. the histological and the electrophoretic profile changes were significative at 6 months. At 10 months the migration profile (CaCl2) recovered to normal levels in the operated hip and the SEM scores for the acetabulum were similar to the non operated control hip after treatment. the serum level of IgA was elevated at the 4th and 6th month postoperatively. the persistence of a metallic implant resulted in degenerative changes parallel to that described for hip chondrolysis as a complication of in-situ pinning; and the cartilage lesion improved with DAR treatment. (c) 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. |
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Kitadai, Humberto Ken [UNIFESP]Takahashi, Helio Kiyoshi [UNIFESP]Straus, Anita Hilda [UNIFESP]Ibanez, J. F.Lucas, R.Kitadai, Fabio Takashi [UNIFESP]Milani, Carlo [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ Metropolitana UnidaUniversidade de São Paulo (USP)2016-01-24T12:41:11Z2016-01-24T12:41:11Z2006-06-01Journal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 24, n. 6, p. 1240-1248, 2006.0736-0266http://repositorio.unifesp.br/handle/11600/28913http://dx.doi.org/10.1002/jor.2018010.1002/jor.20180WOS:000237825600015We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin inhibitor, diacerein (DAR) in the ensuing articular cartilage lesion. Twenty immature beagles were submitted to a surgical K-wire implantation in the hip with the material left in the joint space for 6 months. Twelve animals were sacrificed for histological and biochemical tests. Eight animals were sacrificed at 10 months (half of them treated with DAR) and analyzed by scanning electron microscopy (SEM) and biochemistry of the articular cartilage. Preoperative and monthly C3 and C4 complement and immunoglobulins serum levels were determined. the histological and the electrophoretic profile changes were significative at 6 months. At 10 months the migration profile (CaCl2) recovered to normal levels in the operated hip and the SEM scores for the acetabulum were similar to the non operated control hip after treatment. the serum level of IgA was elevated at the 4th and 6th month postoperatively. the persistence of a metallic implant resulted in degenerative changes parallel to that described for hip chondrolysis as a complication of in-situ pinning; and the cartilage lesion improved with DAR treatment. (c) 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.UNIFESP, Universidade Federal de São Paulo, BR-04664000 São Paulo, BrazilUniv Metropolitana Unida, UNIFMU, São Paulo, BrazilUSP, BR-09500900 São Paulo, BrazilUniversidade Federal de São Paulo, EPM, São Paulo, BrazilWeb of Science1240-1248engWiley-BlackwellJournal of Orthopaedic Researchhttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlinfo:eu-repo/semantics/openAccesschondrolysisexperimentaldiacereinbiochemistryscanning electron microscopyEffect of oral diacerein (DAR) in an experimental hip chondrolysis modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/289132022-11-04 15:40:33.192metadata only accessoai:repositorio.unifesp.br:11600/28913Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:29:39.988791Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model |
title |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model |
spellingShingle |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model Kitadai, Humberto Ken [UNIFESP] chondrolysis experimental diacerein biochemistry scanning electron microscopy |
title_short |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model |
title_full |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model |
title_fullStr |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model |
title_full_unstemmed |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model |
title_sort |
Effect of oral diacerein (DAR) in an experimental hip chondrolysis model |
author |
Kitadai, Humberto Ken [UNIFESP] |
author_facet |
Kitadai, Humberto Ken [UNIFESP] Takahashi, Helio Kiyoshi [UNIFESP] Straus, Anita Hilda [UNIFESP] Ibanez, J. F. Lucas, R. Kitadai, Fabio Takashi [UNIFESP] Milani, Carlo [UNIFESP] |
author_role |
author |
author2 |
Takahashi, Helio Kiyoshi [UNIFESP] Straus, Anita Hilda [UNIFESP] Ibanez, J. F. Lucas, R. Kitadai, Fabio Takashi [UNIFESP] Milani, Carlo [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Metropolitana Unida Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Kitadai, Humberto Ken [UNIFESP] Takahashi, Helio Kiyoshi [UNIFESP] Straus, Anita Hilda [UNIFESP] Ibanez, J. F. Lucas, R. Kitadai, Fabio Takashi [UNIFESP] Milani, Carlo [UNIFESP] |
dc.subject.eng.fl_str_mv |
chondrolysis experimental diacerein biochemistry scanning electron microscopy |
topic |
chondrolysis experimental diacerein biochemistry scanning electron microscopy |
description |
We aimed to reproduce the articular cartilage structural changes in a joint exposed to a metallic implant as in the adolescent pinned hip with persistent joint penetration and secondly, to test the effect of an interleukin inhibitor, diacerein (DAR) in the ensuing articular cartilage lesion. Twenty immature beagles were submitted to a surgical K-wire implantation in the hip with the material left in the joint space for 6 months. Twelve animals were sacrificed for histological and biochemical tests. Eight animals were sacrificed at 10 months (half of them treated with DAR) and analyzed by scanning electron microscopy (SEM) and biochemistry of the articular cartilage. Preoperative and monthly C3 and C4 complement and immunoglobulins serum levels were determined. the histological and the electrophoretic profile changes were significative at 6 months. At 10 months the migration profile (CaCl2) recovered to normal levels in the operated hip and the SEM scores for the acetabulum were similar to the non operated control hip after treatment. the serum level of IgA was elevated at the 4th and 6th month postoperatively. the persistence of a metallic implant resulted in degenerative changes parallel to that described for hip chondrolysis as a complication of in-situ pinning; and the cartilage lesion improved with DAR treatment. (c) 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-06-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:41:11Z |
dc.date.available.fl_str_mv |
2016-01-24T12:41:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 24, n. 6, p. 1240-1248, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/28913 http://dx.doi.org/10.1002/jor.20180 |
dc.identifier.issn.none.fl_str_mv |
0736-0266 |
dc.identifier.doi.none.fl_str_mv |
10.1002/jor.20180 |
dc.identifier.wos.none.fl_str_mv |
WOS:000237825600015 |
identifier_str_mv |
Journal of Orthopaedic Research. Hoboken: John Wiley & Sons Inc, v. 24, n. 6, p. 1240-1248, 2006. 0736-0266 10.1002/jor.20180 WOS:000237825600015 |
url |
http://repositorio.unifesp.br/handle/11600/28913 http://dx.doi.org/10.1002/jor.20180 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Journal of Orthopaedic Research |
dc.rights.driver.fl_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1240-1248 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460298287480832 |