Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis

Detalhes bibliográficos
Autor(a) principal: Souza, Paulo Victor Sgobbi de [UNIFESP]
Data de Publicação: 2016
Outros Autores: Pinto, Wladimir Bocca Vieira de Rezende [UNIFESP], Rezende Filho, Flavio Moura [UNIFESP], Oliveira, Acary Souza Bulle [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/56975
http://dx.doi.org/10.1590/0004-282X20160117
Resumo: Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.
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spelling Souza, Paulo Victor Sgobbi de [UNIFESP]Pinto, Wladimir Bocca Vieira de Rezende [UNIFESP]Rezende Filho, Flavio Moura [UNIFESP]Oliveira, Acary Souza Bulle [UNIFESP]2020-07-31T12:47:39Z2020-07-31T12:47:39Z2016Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 10, p. 849-854, 2016.0004-282Xhttps://repositorio.unifesp.br/handle/11600/56975http://dx.doi.org/10.1590/0004-282X20160117S0004-282X2016001000849.pdfS0004-282X201600100084910.1590/0004-282X20160117WOS:000386578100013Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, BrazilUniversidade Federal de São Paulo, Departamento de Neurologia e Neurocirurgia, São Paulo SP, BrasilWeb of Science849-854engAssoc Arquivos Neuro- PsiquiatriaArquivos De Neuro-Psiquiatriamotor neuronsastrocytemicrogliaamyotrophic lateral sclerosismotor neuron diseaseFar beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo Sp7410info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0004-282X2016001000849.pdfapplication/pdf818991${dspace.ui.url}/bitstream/11600/56975/1/S0004-282X2016001000849.pdf7ebdcac833609ac2aa1b6262615e7006MD51open accessTEXTS0004-282X2016001000849.pdf.txtS0004-282X2016001000849.pdf.txtExtracted texttext/plain24479${dspace.ui.url}/bitstream/11600/56975/2/S0004-282X2016001000849.pdf.txt6c76ff187ce9770a2230d9a9a6aa683eMD52open accessTHUMBNAILS0004-282X2016001000849.pdf.jpgS0004-282X2016001000849.pdf.jpgIM Thumbnailimage/jpeg6989${dspace.ui.url}/bitstream/11600/56975/4/S0004-282X2016001000849.pdf.jpgd300bbde5b1da353b5410c027c00585eMD54open access11600/569752022-07-31 22:33:30.321open accessoai:repositorio.unifesp.br:11600/56975Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:19:59.418745Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
spellingShingle Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
Souza, Paulo Victor Sgobbi de [UNIFESP]
motor neurons
astrocyte
microglia
amyotrophic lateral sclerosis
motor neuron disease
title_short Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_full Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_fullStr Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_full_unstemmed Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
title_sort Far beyond the motor neuron: the role of glial cells in amyotrophic lateral sclerosis
author Souza, Paulo Victor Sgobbi de [UNIFESP]
author_facet Souza, Paulo Victor Sgobbi de [UNIFESP]
Pinto, Wladimir Bocca Vieira de Rezende [UNIFESP]
Rezende Filho, Flavio Moura [UNIFESP]
Oliveira, Acary Souza Bulle [UNIFESP]
author_role author
author2 Pinto, Wladimir Bocca Vieira de Rezende [UNIFESP]
Rezende Filho, Flavio Moura [UNIFESP]
Oliveira, Acary Souza Bulle [UNIFESP]
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza, Paulo Victor Sgobbi de [UNIFESP]
Pinto, Wladimir Bocca Vieira de Rezende [UNIFESP]
Rezende Filho, Flavio Moura [UNIFESP]
Oliveira, Acary Souza Bulle [UNIFESP]
dc.subject.eng.fl_str_mv motor neurons
astrocyte
microglia
amyotrophic lateral sclerosis
motor neuron disease
topic motor neurons
astrocyte
microglia
amyotrophic lateral sclerosis
motor neuron disease
description Motor neuron disease is one of the major groups of neurodegenerative diseases, mainly represented by amyotrophic lateral sclerosis. Despite wide genetic and biochemical data regarding its pathophysiological mechanisms, motor neuron disease develops under a complex network of mechanisms not restricted to the unique functions of the alpha motor neurons but which actually involve diverse functions of glial cell interaction. This review aims to expose some of the leading roles of glial cells in the physiological mechanisms of neuron-glial cell interactions and the mechanisms related to motor neuron survival linked to glial cell functions.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2020-07-31T12:47:39Z
dc.date.available.fl_str_mv 2020-07-31T12:47:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 10, p. 849-854, 2016.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/56975
http://dx.doi.org/10.1590/0004-282X20160117
dc.identifier.issn.none.fl_str_mv 0004-282X
dc.identifier.file.none.fl_str_mv S0004-282X2016001000849.pdf
dc.identifier.scielo.none.fl_str_mv S0004-282X2016001000849
dc.identifier.doi.none.fl_str_mv 10.1590/0004-282X20160117
dc.identifier.wos.none.fl_str_mv WOS:000386578100013
identifier_str_mv Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 74, n. 10, p. 849-854, 2016.
0004-282X
S0004-282X2016001000849.pdf
S0004-282X2016001000849
10.1590/0004-282X20160117
WOS:000386578100013
url https://repositorio.unifesp.br/handle/11600/56975
http://dx.doi.org/10.1590/0004-282X20160117
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Arquivos De Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 849-854
dc.coverage.none.fl_str_mv Sao Paulo Sp
dc.publisher.none.fl_str_mv Assoc Arquivos Neuro- Psiquiatria
publisher.none.fl_str_mv Assoc Arquivos Neuro- Psiquiatria
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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