Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/6006 http://dx.doi.org/10.1590/S0100-879X2010007500104 |
Resumo: | Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions. |
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Santos-Galduróz, Ruth FerreiraGalduróz, José Carlos Fernandes [UNIFESP]Facco, R.L.Hachul, Helena [UNIFESP]Tufik, Sergio [UNIFESP]Universidade Estadual Paulista (UNESP)Universidade Federal do ABC Centro de Matemática, Computação e CogniçãoUniversidade Federal de São Paulo (UNIFESP)Independent researcher in private practice Departamento de Psicobiologia2015-06-14T13:41:57Z2015-06-14T13:41:57Z2010-11-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010.0100-879Xhttp://repositorio.unifesp.br/handle/11600/6006http://dx.doi.org/10.1590/S0100-879X2010007500104S0100-879X2010001100016.pdfS0100-879X201000110001610.1590/S0100-879X2010007500104WOS:000284591800016Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Associação Fundo de Incentivo à Pesquisa (AFIP)Universidade Estadual Paulista Departamento de BiociênciasUniversidade Federal do ABC Centro de Matemática, Computação e CogniçãoUniversidade Federal de São Paulo (UNIFESP) Departamento de PsicobiologiaIndependent researcher in private practice Departamento de PsicobiologiaUNIFESP, Depto. de PsicobiologiaSciELO1123-1126engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchIsoflavoneCognitive disordersAgingInformation integrationMemoryMenopauseEffects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2010001100016.pdfapplication/pdf356557${dspace.ui.url}/bitstream/11600/6006/1/S0100-879X2010001100016.pdfcbc922c4d8e60baf3dd5d28ac2d68ffdMD51open accessTEXTS0100-879X2010001100016.pdf.txtS0100-879X2010001100016.pdf.txtExtracted texttext/plain17515${dspace.ui.url}/bitstream/11600/6006/2/S0100-879X2010001100016.pdf.txtfc1c99e916e1db93d72348269f5f73bfMD52open access11600/60062021-10-05 21:21:42.636open accessoai:repositorio.unifesp.br:11600/6006Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:15:35.672282Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
title |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
spellingShingle |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study Santos-Galduróz, Ruth Ferreira Isoflavone Cognitive disorders Aging Information integration Memory Menopause |
title_short |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
title_full |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
title_fullStr |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
title_full_unstemmed |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
title_sort |
Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study |
author |
Santos-Galduróz, Ruth Ferreira |
author_facet |
Santos-Galduróz, Ruth Ferreira Galduróz, José Carlos Fernandes [UNIFESP] Facco, R.L. Hachul, Helena [UNIFESP] Tufik, Sergio [UNIFESP] |
author_role |
author |
author2 |
Galduróz, José Carlos Fernandes [UNIFESP] Facco, R.L. Hachul, Helena [UNIFESP] Tufik, Sergio [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade Federal do ABC Centro de Matemática, Computação e Cognição Universidade Federal de São Paulo (UNIFESP) Independent researcher in private practice Departamento de Psicobiologia |
dc.contributor.author.fl_str_mv |
Santos-Galduróz, Ruth Ferreira Galduróz, José Carlos Fernandes [UNIFESP] Facco, R.L. Hachul, Helena [UNIFESP] Tufik, Sergio [UNIFESP] |
dc.subject.eng.fl_str_mv |
Isoflavone Cognitive disorders Aging Information integration Memory Menopause |
topic |
Isoflavone Cognitive disorders Aging Information integration Memory Menopause |
description |
Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-11-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:41:57Z |
dc.date.available.fl_str_mv |
2015-06-14T13:41:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/6006 http://dx.doi.org/10.1590/S0100-879X2010007500104 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2010001100016.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2010001100016 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2010007500104 |
dc.identifier.wos.none.fl_str_mv |
WOS:000284591800016 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010. 0100-879X S0100-879X2010001100016.pdf S0100-879X2010001100016 10.1590/S0100-879X2010007500104 WOS:000284591800016 |
url |
http://repositorio.unifesp.br/handle/11600/6006 http://dx.doi.org/10.1590/S0100-879X2010007500104 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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1123-1126 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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