Retinopathy and survival in a population without diabetes the beaver dam eye study
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/30043 http://dx.doi.org/10.1093/aje/kwm126 |
Resumo: | Retinopathy is relatively common in nondiabetic populations, and its long-term prognostic implications are not certain. for this reason, the authors hypothesized that retinal alterations were associated with all-cause and cause-specific mortality in nondiabetic individuals participating in the Beaver Dam Eye Study in Wisconsin. Included in the analysis were 4,294 nondiabetic subjects aged 43-84 years examined at baseline (1988-1990). Retinopathy was classified into four groups by using retinal photographs: 1) no retinopathy, 2) presence of retinal hemorrhages only, 3) presence of retinal microaneurysms only, and 4) presence of moderate or worse retinopathy. the authors analyzed survival during 14 years of follow-up and in 5-year intervals by using time-varying covariates. Baseline prevalence of retinopathy was 7.7%. Adjusting for age, sex, and significant confounders, they observed that moderate retinopathy at baseline was associated with all-cause (hazard ratio = 1.76, 95% confidence interval: 1.16, 2.69) and ischemic heart disease (hazard ratio = 3.17, 95% confidence interval: 1.73, 5.78) mortality after 14 years of follow-up. in the 5-year-interval analysis, the presence of hemorrhages only was significantly related to increased all-cause (hazard ratio = 1.49, 95% confidence interval: 1.05, 2.12) and ischemic heart disease (hazard ratio = 2.43, 95% confidence interval: 1.48, 4.01) mortality. Study results suggest that retinal changes have possible prognostic implications regarding survival of persons without diabetes. |
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Hirai, Flávio Eduardo [UNIFESP]Moss, Scot E.Knudtson, Michael D.Klein, Barbara E. K.Klein, RonaldUniv WisconsinUniversidade Federal de São Paulo (UNIFESP)2016-01-24T13:49:05Z2016-01-24T13:49:05Z2007-09-15American Journal of Epidemiology. Cary: Oxford Univ Press Inc, v. 166, n. 6, p. 724-730, 2007.0002-9262http://repositorio.unifesp.br/handle/11600/30043http://dx.doi.org/10.1093/aje/kwm12610.1093/aje/kwm126WOS:000249328600013Retinopathy is relatively common in nondiabetic populations, and its long-term prognostic implications are not certain. for this reason, the authors hypothesized that retinal alterations were associated with all-cause and cause-specific mortality in nondiabetic individuals participating in the Beaver Dam Eye Study in Wisconsin. Included in the analysis were 4,294 nondiabetic subjects aged 43-84 years examined at baseline (1988-1990). Retinopathy was classified into four groups by using retinal photographs: 1) no retinopathy, 2) presence of retinal hemorrhages only, 3) presence of retinal microaneurysms only, and 4) presence of moderate or worse retinopathy. the authors analyzed survival during 14 years of follow-up and in 5-year intervals by using time-varying covariates. Baseline prevalence of retinopathy was 7.7%. Adjusting for age, sex, and significant confounders, they observed that moderate retinopathy at baseline was associated with all-cause (hazard ratio = 1.76, 95% confidence interval: 1.16, 2.69) and ischemic heart disease (hazard ratio = 3.17, 95% confidence interval: 1.73, 5.78) mortality after 14 years of follow-up. in the 5-year-interval analysis, the presence of hemorrhages only was significantly related to increased all-cause (hazard ratio = 1.49, 95% confidence interval: 1.05, 2.12) and ischemic heart disease (hazard ratio = 2.43, 95% confidence interval: 1.48, 4.01) mortality. Study results suggest that retinal changes have possible prognostic implications regarding survival of persons without diabetes.Univ Wisconsin, Madison Sch Med, Dept Ophthalmol & Visual Sci, Madison, WI 53726 USAUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilWeb of Science724-730engOxford Univ Press IncAmerican Journal of Epidemiologyhttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.htmlinfo:eu-repo/semantics/openAccesseye diseasesmortalityophthalmologyretinaretinal hemorrhageRetinopathy and survival in a population without diabetes the beaver dam eye studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/300432022-11-04 14:18:46.007metadata only accessoai:repositorio.unifesp.br:11600/30043Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:28:37.398817Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Retinopathy and survival in a population without diabetes the beaver dam eye study |
title |
Retinopathy and survival in a population without diabetes the beaver dam eye study |
spellingShingle |
Retinopathy and survival in a population without diabetes the beaver dam eye study Hirai, Flávio Eduardo [UNIFESP] eye diseases mortality ophthalmology retina retinal hemorrhage |
title_short |
Retinopathy and survival in a population without diabetes the beaver dam eye study |
title_full |
Retinopathy and survival in a population without diabetes the beaver dam eye study |
title_fullStr |
Retinopathy and survival in a population without diabetes the beaver dam eye study |
title_full_unstemmed |
Retinopathy and survival in a population without diabetes the beaver dam eye study |
title_sort |
Retinopathy and survival in a population without diabetes the beaver dam eye study |
author |
Hirai, Flávio Eduardo [UNIFESP] |
author_facet |
Hirai, Flávio Eduardo [UNIFESP] Moss, Scot E. Knudtson, Michael D. Klein, Barbara E. K. Klein, Ronald |
author_role |
author |
author2 |
Moss, Scot E. Knudtson, Michael D. Klein, Barbara E. K. Klein, Ronald |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Univ Wisconsin Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Hirai, Flávio Eduardo [UNIFESP] Moss, Scot E. Knudtson, Michael D. Klein, Barbara E. K. Klein, Ronald |
dc.subject.eng.fl_str_mv |
eye diseases mortality ophthalmology retina retinal hemorrhage |
topic |
eye diseases mortality ophthalmology retina retinal hemorrhage |
description |
Retinopathy is relatively common in nondiabetic populations, and its long-term prognostic implications are not certain. for this reason, the authors hypothesized that retinal alterations were associated with all-cause and cause-specific mortality in nondiabetic individuals participating in the Beaver Dam Eye Study in Wisconsin. Included in the analysis were 4,294 nondiabetic subjects aged 43-84 years examined at baseline (1988-1990). Retinopathy was classified into four groups by using retinal photographs: 1) no retinopathy, 2) presence of retinal hemorrhages only, 3) presence of retinal microaneurysms only, and 4) presence of moderate or worse retinopathy. the authors analyzed survival during 14 years of follow-up and in 5-year intervals by using time-varying covariates. Baseline prevalence of retinopathy was 7.7%. Adjusting for age, sex, and significant confounders, they observed that moderate retinopathy at baseline was associated with all-cause (hazard ratio = 1.76, 95% confidence interval: 1.16, 2.69) and ischemic heart disease (hazard ratio = 3.17, 95% confidence interval: 1.73, 5.78) mortality after 14 years of follow-up. in the 5-year-interval analysis, the presence of hemorrhages only was significantly related to increased all-cause (hazard ratio = 1.49, 95% confidence interval: 1.05, 2.12) and ischemic heart disease (hazard ratio = 2.43, 95% confidence interval: 1.48, 4.01) mortality. Study results suggest that retinal changes have possible prognostic implications regarding survival of persons without diabetes. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-09-15 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:49:05Z |
dc.date.available.fl_str_mv |
2016-01-24T13:49:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal of Epidemiology. Cary: Oxford Univ Press Inc, v. 166, n. 6, p. 724-730, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/30043 http://dx.doi.org/10.1093/aje/kwm126 |
dc.identifier.issn.none.fl_str_mv |
0002-9262 |
dc.identifier.doi.none.fl_str_mv |
10.1093/aje/kwm126 |
dc.identifier.wos.none.fl_str_mv |
WOS:000249328600013 |
identifier_str_mv |
American Journal of Epidemiology. Cary: Oxford Univ Press Inc, v. 166, n. 6, p. 724-730, 2007. 0002-9262 10.1093/aje/kwm126 WOS:000249328600013 |
url |
http://repositorio.unifesp.br/handle/11600/30043 http://dx.doi.org/10.1093/aje/kwm126 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal of Epidemiology |
dc.rights.driver.fl_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
724-730 |
dc.publisher.none.fl_str_mv |
Oxford Univ Press Inc |
publisher.none.fl_str_mv |
Oxford Univ Press Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
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