Traumatic spinal cord injury: current concepts and treatment update
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54330 http://dx.doi.org/10.1590/0004-282X20170048 |
Resumo: | Spinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days, and even weeks, after the event. There is convincing evidence that hypotension contributes to secondary injury after acute SCI. Surgical decompression aims at relieving mechanical pressure on the microvascular circulation, therefore reducing hypoxia and ischemia. The role of methylprednisolone as a therapeutic option is still a matter of debate, however most guidelines do not recommend its regular use. Neuroprotective therapies aiming to reduce further injury have been studied and many others are underway. Neuroregenerative therapies are being extensively investigated, with cell based therapy being very promising. |
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Rouanet, Carolina [UNIFESP]Reges, Danyelle [UNIFESP]Rocha, Eva [UNIFESP]Gagliardi, Vivian [UNIFESP]Silva, Gisele Sampaio [UNIFESP]2020-07-13T11:52:56Z2020-07-13T11:52:56Z2017Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 6, p. 387-393, 2017.0004-282Xhttps://repositorio.unifesp.br/handle/11600/54330http://dx.doi.org/10.1590/0004-282X20170048S0004-282X2017000600387.pdfS0004-282X201700060038710.1590/0004-282X20170048WOS:000404476400011Spinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days, and even weeks, after the event. There is convincing evidence that hypotension contributes to secondary injury after acute SCI. Surgical decompression aims at relieving mechanical pressure on the microvascular circulation, therefore reducing hypoxia and ischemia. The role of methylprednisolone as a therapeutic option is still a matter of debate, however most guidelines do not recommend its regular use. Neuroprotective therapies aiming to reduce further injury have been studied and many others are underway. Neuroregenerative therapies are being extensively investigated, with cell based therapy being very promising.Univ Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Neurol & Neurocirurgia, Sao Paulo, SP, BrazilWeb of Science387-393engAssoc Arquivos Neuro- PsiquiatriaArquivos De Neuro-Psiquiatriaspinal cord injuriesspinal cord compressionneurosurgeryspinal cord regenerationcell- and tissue-based therapyTraumatic spinal cord injury: current concepts and treatment updateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo Sp756info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0004-282X2017000600387.pdfapplication/pdf425256${dspace.ui.url}/bitstream/11600/54330/1/S0004-282X2017000600387.pdf06c22a755788057473030501b7f92b84MD51open accessTEXTS0004-282X2017000600387.pdf.txtS0004-282X2017000600387.pdf.txtExtracted texttext/plain36323${dspace.ui.url}/bitstream/11600/54330/2/S0004-282X2017000600387.pdf.txt17b0a44010253a7d52ddc4b39325713aMD52open accessTHUMBNAILS0004-282X2017000600387.pdf.jpgS0004-282X2017000600387.pdf.jpgIM Thumbnailimage/jpeg6997${dspace.ui.url}/bitstream/11600/54330/4/S0004-282X2017000600387.pdf.jpg9f283f6ed60290911b36c1b7a9a24954MD54open access11600/543302022-08-01 07:19:25.503open accessoai:repositorio.unifesp.br:11600/54330Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:21:14.921003Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Traumatic spinal cord injury: current concepts and treatment update |
title |
Traumatic spinal cord injury: current concepts and treatment update |
spellingShingle |
Traumatic spinal cord injury: current concepts and treatment update Rouanet, Carolina [UNIFESP] spinal cord injuries spinal cord compression neurosurgery spinal cord regeneration cell- and tissue-based therapy |
title_short |
Traumatic spinal cord injury: current concepts and treatment update |
title_full |
Traumatic spinal cord injury: current concepts and treatment update |
title_fullStr |
Traumatic spinal cord injury: current concepts and treatment update |
title_full_unstemmed |
Traumatic spinal cord injury: current concepts and treatment update |
title_sort |
Traumatic spinal cord injury: current concepts and treatment update |
author |
Rouanet, Carolina [UNIFESP] |
author_facet |
Rouanet, Carolina [UNIFESP] Reges, Danyelle [UNIFESP] Rocha, Eva [UNIFESP] Gagliardi, Vivian [UNIFESP] Silva, Gisele Sampaio [UNIFESP] |
author_role |
author |
author2 |
Reges, Danyelle [UNIFESP] Rocha, Eva [UNIFESP] Gagliardi, Vivian [UNIFESP] Silva, Gisele Sampaio [UNIFESP] |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Rouanet, Carolina [UNIFESP] Reges, Danyelle [UNIFESP] Rocha, Eva [UNIFESP] Gagliardi, Vivian [UNIFESP] Silva, Gisele Sampaio [UNIFESP] |
dc.subject.eng.fl_str_mv |
spinal cord injuries spinal cord compression neurosurgery spinal cord regeneration cell- and tissue-based therapy |
topic |
spinal cord injuries spinal cord compression neurosurgery spinal cord regeneration cell- and tissue-based therapy |
description |
Spinal cord injury (SCI) affects 1.3 million North Americans, with more than half occurring after trauma. In Brazil, few studies have evaluated the epidemiology of SCI with an estimated incidence of 16 to 26 per million per year. The final extent of the spinal cord damage results from primary and secondary mechanisms that start at the moment of the injury and go on for days, and even weeks, after the event. There is convincing evidence that hypotension contributes to secondary injury after acute SCI. Surgical decompression aims at relieving mechanical pressure on the microvascular circulation, therefore reducing hypoxia and ischemia. The role of methylprednisolone as a therapeutic option is still a matter of debate, however most guidelines do not recommend its regular use. Neuroprotective therapies aiming to reduce further injury have been studied and many others are underway. Neuroregenerative therapies are being extensively investigated, with cell based therapy being very promising. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
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2020-07-13T11:52:56Z |
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2020-07-13T11:52:56Z |
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info:eu-repo/semantics/publishedVersion |
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Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 6, p. 387-393, 2017. |
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https://repositorio.unifesp.br/handle/11600/54330 http://dx.doi.org/10.1590/0004-282X20170048 |
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0004-282X |
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S0004-282X2017000600387.pdf |
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S0004-282X2017000600387 |
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10.1590/0004-282X20170048 |
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WOS:000404476400011 |
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Arquivos De Neuro-Psiquiatria. Sao Paulo Sp, v. 75, n. 6, p. 387-393, 2017. 0004-282X S0004-282X2017000600387.pdf S0004-282X2017000600387 10.1590/0004-282X20170048 WOS:000404476400011 |
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https://repositorio.unifesp.br/handle/11600/54330 http://dx.doi.org/10.1590/0004-282X20170048 |
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eng |
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Arquivos De Neuro-Psiquiatria |
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Sao Paulo Sp |
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Assoc Arquivos Neuro- Psiquiatria |
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Assoc Arquivos Neuro- Psiquiatria |
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