Nutritional status of hemodialysis patients with secondary hyperparathyroidism
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1049 http://dx.doi.org/10.1590/S0100-879X2000001100007 |
Resumo: | The repercussions of secondary hyperparathyroidism on the nutritional status of chronic renal failure patients have not been well established. Therefore, the aim of this study was to compare the nutritional indices of hemodialysis patients with and without secondary hyperparathyroidism. Sixteen hemodialysis patients with serum parathyroid hormone (PTH) levels higher than 420 pg/ml (hyperparathyroidism group) were matched for gender, age and length of dialysis treatment to 16 patients with serum PTH between 64 and 290 pg/ml (control group). The following parameters were assessed: anthropometric indices (body mass index, skinfold thickness, midarm muscle circumference and body fat), 4-day food diaries, protein catabolic rate, biochemical indices (blood urea nitrogen, serum creatinine, albumin, ionized calcium, inorganic phosphorus, serum alkaline phosphatase, PTH, pH and HCO3) and dialysis efficiency. We did not observe differences in the anthropometric indices between the two groups. Only calcium intake was significantly different between groups (307.9 mg/day for the hyperparathyroidism group vs 475.8 mg/day for the control group). Protein catabolic rate tended to be higher in the hyperparathyroidism group compared to the control group (1.3 vs 0.9 g kg-1 day-1; P = 0.08). Except for blood urea nitrogen (86.4 vs 75.7 mg/dl), alkaline phosphatase (175 vs 65 U/l) and PTH (898 vs 155 pg/ml), no other differences were found between groups in the biochemical indices studied. PTH was directly correlated with protein catabolic rate (r = 0.61; P<0.05) and length of dialysis (r = 0.53; P<0.05) only in the hyperparathyroidism group. Considering the indices used, we could not demonstrate the deleterious effect of high PTH levels on the nutritional status of hemodialysis patients. Indirect evidence, however, suggests an action of PTH on protein metabolism. |
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Rezende, Luciana Trindade Teixeira [UNIFESP]Cuppari, Lilian [UNIFESP]Carvalho, A.b. [UNIFESP]Canziani, Maria Eugênia Fernandes [UNIFESP]Manfredi, Sílvia Regina [UNIFESP]Cendoroglo Neto, Miguel [UNIFESP]Sigulem, Dirce Maria [UNIFESP]Draibe, Sergio Antonio [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:25:08Z2015-06-14T13:25:08Z2000-11-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 11, p. 1305-1311, 2000.0100-879Xhttp://repositorio.unifesp.br/handle/11600/1049http://dx.doi.org/10.1590/S0100-879X2000001100007S0100-879X2000001100007.pdfS0100-879X200000110000710.1590/S0100-879X2000001100007WOS:000165487100007The repercussions of secondary hyperparathyroidism on the nutritional status of chronic renal failure patients have not been well established. Therefore, the aim of this study was to compare the nutritional indices of hemodialysis patients with and without secondary hyperparathyroidism. Sixteen hemodialysis patients with serum parathyroid hormone (PTH) levels higher than 420 pg/ml (hyperparathyroidism group) were matched for gender, age and length of dialysis treatment to 16 patients with serum PTH between 64 and 290 pg/ml (control group). The following parameters were assessed: anthropometric indices (body mass index, skinfold thickness, midarm muscle circumference and body fat), 4-day food diaries, protein catabolic rate, biochemical indices (blood urea nitrogen, serum creatinine, albumin, ionized calcium, inorganic phosphorus, serum alkaline phosphatase, PTH, pH and HCO3) and dialysis efficiency. We did not observe differences in the anthropometric indices between the two groups. Only calcium intake was significantly different between groups (307.9 mg/day for the hyperparathyroidism group vs 475.8 mg/day for the control group). Protein catabolic rate tended to be higher in the hyperparathyroidism group compared to the control group (1.3 vs 0.9 g kg-1 day-1; P = 0.08). Except for blood urea nitrogen (86.4 vs 75.7 mg/dl), alkaline phosphatase (175 vs 65 U/l) and PTH (898 vs 155 pg/ml), no other differences were found between groups in the biochemical indices studied. PTH was directly correlated with protein catabolic rate (r = 0.61; P<0.05) and length of dialysis (r = 0.53; P<0.05) only in the hyperparathyroidism group. Considering the indices used, we could not demonstrate the deleterious effect of high PTH levels on the nutritional status of hemodialysis patients. Indirect evidence, however, suggests an action of PTH on protein metabolism.Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina Disciplina de NefrologiaUniversidade Federal de São Paulo (UNIFESP) Departamento de PediatriaUNIFESP, Depto. de Medicina Disciplina de NefrologiaUNIFESP, Depto. de PediatriaSciELO1305-1311engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Researchnutritional assessmentparathormonechronic renal failuresecondary hyperparathyroidismNutritional status of hemodialysis patients with secondary hyperparathyroidisminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2000001100007.pdfapplication/pdf182259${dspace.ui.url}/bitstream/11600/1049/1/S0100-879X2000001100007.pdf3f3ddde1fa7ea4c4e26a69dfe69484ccMD51open accessTEXTS0100-879X2000001100007.pdf.txtS0100-879X2000001100007.pdf.txtExtracted texttext/plain27409${dspace.ui.url}/bitstream/11600/1049/21/S0100-879X2000001100007.pdf.txt53e74756c4b9459793cf5c5143bcd0a3MD521open accessTHUMBNAILS0100-879X2000001100007.pdf.jpgS0100-879X2000001100007.pdf.jpgIM Thumbnailimage/jpeg5319${dspace.ui.url}/bitstream/11600/1049/23/S0100-879X2000001100007.pdf.jpg9bd9077c2ddbd15b3bb17dc688783905MD523open access11600/10492023-06-05 20:22:23.848open accessoai:repositorio.unifesp.br:11600/1049Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T23:22:23Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism |
title |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism |
spellingShingle |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism Rezende, Luciana Trindade Teixeira [UNIFESP] nutritional assessment parathormone chronic renal failure secondary hyperparathyroidism |
title_short |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism |
title_full |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism |
title_fullStr |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism |
title_full_unstemmed |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism |
title_sort |
Nutritional status of hemodialysis patients with secondary hyperparathyroidism |
author |
Rezende, Luciana Trindade Teixeira [UNIFESP] |
author_facet |
Rezende, Luciana Trindade Teixeira [UNIFESP] Cuppari, Lilian [UNIFESP] Carvalho, A.b. [UNIFESP] Canziani, Maria Eugênia Fernandes [UNIFESP] Manfredi, Sílvia Regina [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Sigulem, Dirce Maria [UNIFESP] Draibe, Sergio Antonio [UNIFESP] |
author_role |
author |
author2 |
Cuppari, Lilian [UNIFESP] Carvalho, A.b. [UNIFESP] Canziani, Maria Eugênia Fernandes [UNIFESP] Manfredi, Sílvia Regina [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Sigulem, Dirce Maria [UNIFESP] Draibe, Sergio Antonio [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Rezende, Luciana Trindade Teixeira [UNIFESP] Cuppari, Lilian [UNIFESP] Carvalho, A.b. [UNIFESP] Canziani, Maria Eugênia Fernandes [UNIFESP] Manfredi, Sílvia Regina [UNIFESP] Cendoroglo Neto, Miguel [UNIFESP] Sigulem, Dirce Maria [UNIFESP] Draibe, Sergio Antonio [UNIFESP] |
dc.subject.eng.fl_str_mv |
nutritional assessment parathormone chronic renal failure secondary hyperparathyroidism |
topic |
nutritional assessment parathormone chronic renal failure secondary hyperparathyroidism |
description |
The repercussions of secondary hyperparathyroidism on the nutritional status of chronic renal failure patients have not been well established. Therefore, the aim of this study was to compare the nutritional indices of hemodialysis patients with and without secondary hyperparathyroidism. Sixteen hemodialysis patients with serum parathyroid hormone (PTH) levels higher than 420 pg/ml (hyperparathyroidism group) were matched for gender, age and length of dialysis treatment to 16 patients with serum PTH between 64 and 290 pg/ml (control group). The following parameters were assessed: anthropometric indices (body mass index, skinfold thickness, midarm muscle circumference and body fat), 4-day food diaries, protein catabolic rate, biochemical indices (blood urea nitrogen, serum creatinine, albumin, ionized calcium, inorganic phosphorus, serum alkaline phosphatase, PTH, pH and HCO3) and dialysis efficiency. We did not observe differences in the anthropometric indices between the two groups. Only calcium intake was significantly different between groups (307.9 mg/day for the hyperparathyroidism group vs 475.8 mg/day for the control group). Protein catabolic rate tended to be higher in the hyperparathyroidism group compared to the control group (1.3 vs 0.9 g kg-1 day-1; P = 0.08). Except for blood urea nitrogen (86.4 vs 75.7 mg/dl), alkaline phosphatase (175 vs 65 U/l) and PTH (898 vs 155 pg/ml), no other differences were found between groups in the biochemical indices studied. PTH was directly correlated with protein catabolic rate (r = 0.61; P<0.05) and length of dialysis (r = 0.53; P<0.05) only in the hyperparathyroidism group. Considering the indices used, we could not demonstrate the deleterious effect of high PTH levels on the nutritional status of hemodialysis patients. Indirect evidence, however, suggests an action of PTH on protein metabolism. |
publishDate |
2000 |
dc.date.issued.fl_str_mv |
2000-11-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:25:08Z |
dc.date.available.fl_str_mv |
2015-06-14T13:25:08Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 11, p. 1305-1311, 2000. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1049 http://dx.doi.org/10.1590/S0100-879X2000001100007 |
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0100-879X |
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S0100-879X2000001100007.pdf |
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S0100-879X2000001100007 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2000001100007 |
dc.identifier.wos.none.fl_str_mv |
WOS:000165487100007 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 33, n. 11, p. 1305-1311, 2000. 0100-879X S0100-879X2000001100007.pdf S0100-879X2000001100007 10.1590/S0100-879X2000001100007 WOS:000165487100007 |
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http://repositorio.unifesp.br/handle/11600/1049 http://dx.doi.org/10.1590/S0100-879X2000001100007 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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1305-1311 |
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Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
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