Non-invasive diagnosis of liver fibrosis in chronic hepatitis C
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37556 http://dx.doi.org/10.3748/wjg.v20.i11.2854 |
Resumo: | Assessment of liver fibrosis in chronic hepatitis C virus (HCV) infection is considered a relevant part of patient care and key for decision making. Although liver biopsy has been considered the gold standard for staging liver fibrosis, it is an invasive technique and subject to sampling errors and significant intra-and inter-observer variability. Over the last decade, several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection, with variable performance. Besides the clear advantage of being noninvasive, a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver biopsy. in addition, these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional risk. However, in general, these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic conditions. These methods are either serum markers (usually combined in a mathematical model) or imaging modalities that can be used separately or combined in algorithms to improve accuracy. in this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C, their advantages, limitations and application in clinical practice. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved. |
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Schiavon, Leonardo de LuccaNarciso-Schiavon, Janaína LuzCarvalho-Filho, Roberto José de [UNIFESP]Universidade Federal de Santa Catarina (UFSC)Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:35:28Z2016-01-24T14:35:28Z2014-03-21World Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 20, n. 11, p. 2854-2866, 2014.1007-9327http://repositorio.unifesp.br/handle/11600/37556http://dx.doi.org/10.3748/wjg.v20.i11.285410.3748/wjg.v20.i11.2854WOS:000333667200014Assessment of liver fibrosis in chronic hepatitis C virus (HCV) infection is considered a relevant part of patient care and key for decision making. Although liver biopsy has been considered the gold standard for staging liver fibrosis, it is an invasive technique and subject to sampling errors and significant intra-and inter-observer variability. Over the last decade, several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection, with variable performance. Besides the clear advantage of being noninvasive, a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver biopsy. in addition, these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional risk. However, in general, these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic conditions. These methods are either serum markers (usually combined in a mathematical model) or imaging modalities that can be used separately or combined in algorithms to improve accuracy. in this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C, their advantages, limitations and application in clinical practice. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Univ Fed Santa Catarina, Dept Internal Med, Div Gastroenterol, BR-88040900 Florianopolis, SC, BrazilUniversidade Federal de São Paulo, Dept Med, Div Gastroenterol, BR-04023900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Med, Div Gastroenterol, BR-04023900 São Paulo, BrazilWeb of Science2854-2866engBaishideng Publ Grp Co LtdWorld Journal of GastroenterologyLiver fibrosisLiver cirrhosisHepatitis CDiagnosisElasticity imaging techniquesNon-invasive diagnosis of liver fibrosis in chronic hepatitis Cinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/375562022-11-04 15:40:33.781metadata only accessoai:repositorio.unifesp.br:11600/37556Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:29:41.798230Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C |
title |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C |
spellingShingle |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C Schiavon, Leonardo de Lucca Liver fibrosis Liver cirrhosis Hepatitis C Diagnosis Elasticity imaging techniques |
title_short |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C |
title_full |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C |
title_fullStr |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C |
title_full_unstemmed |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C |
title_sort |
Non-invasive diagnosis of liver fibrosis in chronic hepatitis C |
author |
Schiavon, Leonardo de Lucca |
author_facet |
Schiavon, Leonardo de Lucca Narciso-Schiavon, Janaína Luz Carvalho-Filho, Roberto José de [UNIFESP] |
author_role |
author |
author2 |
Narciso-Schiavon, Janaína Luz Carvalho-Filho, Roberto José de [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de Santa Catarina (UFSC) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Schiavon, Leonardo de Lucca Narciso-Schiavon, Janaína Luz Carvalho-Filho, Roberto José de [UNIFESP] |
dc.subject.eng.fl_str_mv |
Liver fibrosis Liver cirrhosis Hepatitis C Diagnosis Elasticity imaging techniques |
topic |
Liver fibrosis Liver cirrhosis Hepatitis C Diagnosis Elasticity imaging techniques |
description |
Assessment of liver fibrosis in chronic hepatitis C virus (HCV) infection is considered a relevant part of patient care and key for decision making. Although liver biopsy has been considered the gold standard for staging liver fibrosis, it is an invasive technique and subject to sampling errors and significant intra-and inter-observer variability. Over the last decade, several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection, with variable performance. Besides the clear advantage of being noninvasive, a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver biopsy. in addition, these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional risk. However, in general, these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic conditions. These methods are either serum markers (usually combined in a mathematical model) or imaging modalities that can be used separately or combined in algorithms to improve accuracy. in this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C, their advantages, limitations and application in clinical practice. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-03-21 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:35:28Z |
dc.date.available.fl_str_mv |
2016-01-24T14:35:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
World Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 20, n. 11, p. 2854-2866, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37556 http://dx.doi.org/10.3748/wjg.v20.i11.2854 |
dc.identifier.issn.none.fl_str_mv |
1007-9327 |
dc.identifier.doi.none.fl_str_mv |
10.3748/wjg.v20.i11.2854 |
dc.identifier.wos.none.fl_str_mv |
WOS:000333667200014 |
identifier_str_mv |
World Journal of Gastroenterology. Wanchai: Baishideng Publ Grp Co Ltd, v. 20, n. 11, p. 2854-2866, 2014. 1007-9327 10.3748/wjg.v20.i11.2854 WOS:000333667200014 |
url |
http://repositorio.unifesp.br/handle/11600/37556 http://dx.doi.org/10.3748/wjg.v20.i11.2854 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
World Journal of Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2854-2866 |
dc.publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
publisher.none.fl_str_mv |
Baishideng Publ Grp Co Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460238385479680 |