Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease
Main Author: | |
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Publication Date: | 2009 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/31537 http://dx.doi.org/10.1164/rccm.200811-1793OC |
Summary: | Rationale: Normoxic heliox (mixture of 79% He and 21% O(2)) may enhance exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). It remains to be determined whether part of these beneficial effects could be ascribed to increased O(2) delivery (O(2)DEL) to locomotor muscles.Objectives: To investigate the effects of heliox on peripheral O(2)DEL and utilization during exercise in moderate to severe COPD.Methods: Twelve mildly hypoxic or nonhypoxemic men (FEV(1) = 45.0 +/- 13.0% predicted) underwent constant-work rate tests (70-80% peak) to the limit of tolerance while receiving heliox or room air. Near-infrared spectroscopy determined changes (Delta) in leg muscle deoxygenation (deoxyhemoglobin concentration [HHb], an index of fractional O(2) extraction), and surface electromyography estimated muscle fiber recruitment (n = 5). Q and Spo(2) were monitored by impedance cardiography and pulse oximetry, respectively.Measurements and Main Results: Heliox significantly decreased dynamic hyperinflation and increased exercise tolerance compared with room air (640 +/- 95 s vs. 371 +/- 100 s; P < 0.01). Heliox also accelerated on-exercise dynamics of (, which were accompanied by faster O(2) uptake kinetics and slower Delta[HHb] responses (P < 0.05). During steady-state exercise, Spo(2)-corrected Delta[HHb] values decreased with heliox despite no significant changes in cardiac output. Muscle fiber recruitment and leg effort scores were also diminished (P < 0.05). On a multiple regression analysis, reductions in dynamic hyperinflation, dyspnea, and Delta[HHb] were independently related to improvements in exercise tolerance with heliox (R(2) = 0.91; p < 0.01).Conclusions: Heliox increases lower limb O(2)DEL and utilization during dynamic exercise in patients with moderate to severe COPD. These effects enhance exercise tolerance in this patient population. |
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Chiappa, Gaspar Rogério da Silva [UNIFESP]Queiroga, Fernando [UNIFESP]Meda, Ethiane [UNIFESP]Ferreira, Leonardo Franklin [UNIFESP]Diefenthaeler, FernandoNunes, Marcos [UNIFESP]Vaz, Marco A.Machado, Maria Christina Lombardi Oliveira [UNIFESP]Nery, Luiz Eduardo [UNIFESP]Neder, Jose Alberto [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ KentuckyUniv Fed Rio Grande do Sul2016-01-24T13:52:34Z2016-01-24T13:52:34Z2009-06-01American Journal of Respiratory and Critical Care Medicine. New York: Amer Thoracic Soc, v. 179, n. 11, p. 1004-1010, 2009.1073-449Xhttp://repositorio.unifesp.br/handle/11600/31537http://dx.doi.org/10.1164/rccm.200811-1793OC10.1164/rccm.200811-1793OCWOS:000266509200008Rationale: Normoxic heliox (mixture of 79% He and 21% O(2)) may enhance exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). It remains to be determined whether part of these beneficial effects could be ascribed to increased O(2) delivery (O(2)DEL) to locomotor muscles.Objectives: To investigate the effects of heliox on peripheral O(2)DEL and utilization during exercise in moderate to severe COPD.Methods: Twelve mildly hypoxic or nonhypoxemic men (FEV(1) = 45.0 +/- 13.0% predicted) underwent constant-work rate tests (70-80% peak) to the limit of tolerance while receiving heliox or room air. Near-infrared spectroscopy determined changes (Delta) in leg muscle deoxygenation (deoxyhemoglobin concentration [HHb], an index of fractional O(2) extraction), and surface electromyography estimated muscle fiber recruitment (n = 5). Q and Spo(2) were monitored by impedance cardiography and pulse oximetry, respectively.Measurements and Main Results: Heliox significantly decreased dynamic hyperinflation and increased exercise tolerance compared with room air (640 +/- 95 s vs. 371 +/- 100 s; P < 0.01). Heliox also accelerated on-exercise dynamics of (, which were accompanied by faster O(2) uptake kinetics and slower Delta[HHb] responses (P < 0.05). During steady-state exercise, Spo(2)-corrected Delta[HHb] values decreased with heliox despite no significant changes in cardiac output. Muscle fiber recruitment and leg effort scores were also diminished (P < 0.05). On a multiple regression analysis, reductions in dynamic hyperinflation, dyspnea, and Delta[HHb] were independently related to improvements in exercise tolerance with heliox (R(2) = 0.91; p < 0.01).Conclusions: Heliox increases lower limb O(2)DEL and utilization during dynamic exercise in patients with moderate to severe COPD. These effects enhance exercise tolerance in this patient population.Pulmonary Function and Clinical Exercise Physiology Unit (Division of Respiratory Diseases, Federal University of São Paulo (UNIFESP), Brazil)Universidade Federal de São Paulo, Dept Med, Div Resp Dis, Pulm Funct & Clin Exercise Physiol Unit SEFICE, BR-04020050 São Paulo, BrazilUniv Kentucky, Dept Physiol, Lexington, KY USAUniv Fed Rio Grande do Sul, Sch Phys Educ, Exercise Res Lab, Porto Alegre, RS, BrazilUniversidade Federal de São Paulo, Dept Med, Div Resp Dis, Pulm Funct & Clin Exercise Physiol Unit SEFICE, BR-04020050 São Paulo, BrazilWeb of Science1004-1010engAmer Thoracic SocAmerican Journal of Respiratory and Critical Care Medicinechronic obstructive pulmonary diseaseheliumexercise toleranceoxygen consumptionnear-infrared spectroscopyHeliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/315372023-01-30 22:33:31.01metadata only accessoai:repositorio.unifesp.br:11600/31537Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:44:58.590053Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease |
title |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease |
spellingShingle |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease Chiappa, Gaspar Rogério da Silva [UNIFESP] chronic obstructive pulmonary disease helium exercise tolerance oxygen consumption near-infrared spectroscopy |
title_short |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease |
title_full |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease |
title_fullStr |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease |
title_full_unstemmed |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease |
title_sort |
Heliox Improves Oxygen Delivery and Utilization during Dynamic Exercise in Patients with Chronic Obstructive Pulmonary Disease |
author |
Chiappa, Gaspar Rogério da Silva [UNIFESP] |
author_facet |
Chiappa, Gaspar Rogério da Silva [UNIFESP] Queiroga, Fernando [UNIFESP] Meda, Ethiane [UNIFESP] Ferreira, Leonardo Franklin [UNIFESP] Diefenthaeler, Fernando Nunes, Marcos [UNIFESP] Vaz, Marco A. Machado, Maria Christina Lombardi Oliveira [UNIFESP] Nery, Luiz Eduardo [UNIFESP] Neder, Jose Alberto [UNIFESP] |
author_role |
author |
author2 |
Queiroga, Fernando [UNIFESP] Meda, Ethiane [UNIFESP] Ferreira, Leonardo Franklin [UNIFESP] Diefenthaeler, Fernando Nunes, Marcos [UNIFESP] Vaz, Marco A. Machado, Maria Christina Lombardi Oliveira [UNIFESP] Nery, Luiz Eduardo [UNIFESP] Neder, Jose Alberto [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Kentucky Univ Fed Rio Grande do Sul |
dc.contributor.author.fl_str_mv |
Chiappa, Gaspar Rogério da Silva [UNIFESP] Queiroga, Fernando [UNIFESP] Meda, Ethiane [UNIFESP] Ferreira, Leonardo Franklin [UNIFESP] Diefenthaeler, Fernando Nunes, Marcos [UNIFESP] Vaz, Marco A. Machado, Maria Christina Lombardi Oliveira [UNIFESP] Nery, Luiz Eduardo [UNIFESP] Neder, Jose Alberto [UNIFESP] |
dc.subject.eng.fl_str_mv |
chronic obstructive pulmonary disease helium exercise tolerance oxygen consumption near-infrared spectroscopy |
topic |
chronic obstructive pulmonary disease helium exercise tolerance oxygen consumption near-infrared spectroscopy |
description |
Rationale: Normoxic heliox (mixture of 79% He and 21% O(2)) may enhance exercise tolerance in patients with chronic obstructive pulmonary disease (COPD). It remains to be determined whether part of these beneficial effects could be ascribed to increased O(2) delivery (O(2)DEL) to locomotor muscles.Objectives: To investigate the effects of heliox on peripheral O(2)DEL and utilization during exercise in moderate to severe COPD.Methods: Twelve mildly hypoxic or nonhypoxemic men (FEV(1) = 45.0 +/- 13.0% predicted) underwent constant-work rate tests (70-80% peak) to the limit of tolerance while receiving heliox or room air. Near-infrared spectroscopy determined changes (Delta) in leg muscle deoxygenation (deoxyhemoglobin concentration [HHb], an index of fractional O(2) extraction), and surface electromyography estimated muscle fiber recruitment (n = 5). Q and Spo(2) were monitored by impedance cardiography and pulse oximetry, respectively.Measurements and Main Results: Heliox significantly decreased dynamic hyperinflation and increased exercise tolerance compared with room air (640 +/- 95 s vs. 371 +/- 100 s; P < 0.01). Heliox also accelerated on-exercise dynamics of (, which were accompanied by faster O(2) uptake kinetics and slower Delta[HHb] responses (P < 0.05). During steady-state exercise, Spo(2)-corrected Delta[HHb] values decreased with heliox despite no significant changes in cardiac output. Muscle fiber recruitment and leg effort scores were also diminished (P < 0.05). On a multiple regression analysis, reductions in dynamic hyperinflation, dyspnea, and Delta[HHb] were independently related to improvements in exercise tolerance with heliox (R(2) = 0.91; p < 0.01).Conclusions: Heliox increases lower limb O(2)DEL and utilization during dynamic exercise in patients with moderate to severe COPD. These effects enhance exercise tolerance in this patient population. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-06-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:52:34Z |
dc.date.available.fl_str_mv |
2016-01-24T13:52:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal of Respiratory and Critical Care Medicine. New York: Amer Thoracic Soc, v. 179, n. 11, p. 1004-1010, 2009. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/31537 http://dx.doi.org/10.1164/rccm.200811-1793OC |
dc.identifier.issn.none.fl_str_mv |
1073-449X |
dc.identifier.doi.none.fl_str_mv |
10.1164/rccm.200811-1793OC |
dc.identifier.wos.none.fl_str_mv |
WOS:000266509200008 |
identifier_str_mv |
American Journal of Respiratory and Critical Care Medicine. New York: Amer Thoracic Soc, v. 179, n. 11, p. 1004-1010, 2009. 1073-449X 10.1164/rccm.200811-1793OC WOS:000266509200008 |
url |
http://repositorio.unifesp.br/handle/11600/31537 http://dx.doi.org/10.1164/rccm.200811-1793OC |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal of Respiratory and Critical Care Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1004-1010 |
dc.publisher.none.fl_str_mv |
Amer Thoracic Soc |
publisher.none.fl_str_mv |
Amer Thoracic Soc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460335467888640 |