Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | https://repositorio.unifesp.br/handle/11600/55618 http://dx.doi.org/10.1002/jnr.24196 |
Resumo: | There are a considerable number of studies concerning the behavioral effects of physical exercise on the epileptic brain |
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Almeida, Alexandre Aparecido de [UNIFESP]Silva, Sergio Gomes daLopim, Glauber Menezes [UNIFESP]Campos, Diego Vannucci [UNIFESP]Fernandes, Jansen [UNIFESP]Cabral, Francisco RomeroArida, Ricardo Mario [UNIFESP]2020-07-20T16:30:58Z2020-07-20T16:30:58Z2018Journal Of Neuroscience Research. Hoboken, v. 96, n. 5, p. 911-920, 2018.0360-4012https://repositorio.unifesp.br/handle/11600/55618http://dx.doi.org/10.1002/jnr.2419610.1002/jnr.24196WOS:000427481100016There are a considerable number of studies concerning the behavioral effects of physical exercise on the epileptic brainhowever, the intracellular signaling mechanisms involved remain unclear. We investigated the effects of aerobic exercise on hippocampal levels of brain-derived neurotrophic factor (BDNF), expression of its receptor tropomyosin receptor kinase B (TrkB), and activation of intracellular proteins related to BDNF-TrkB signaling in male Wistar rats with pilocarpine-induced epilepsy. Thirty days after the first spontaneous seizure, rats from the exercise group undertook a 30-day physical exercise program on the treadmill. Thereafter, BDNF levels, expression of TrkB, and activation of intracellular proteins were quantified by enzyme-linked immunosorbent assay, Western blotting, and multiplex assay, respectively. Statistical analyses were conducted using nonparametric tests. Rats with epilepsy presented decreased BDNF levels compared with control rats. BDNF levels increased significantly in the exercise group compared with the epileptic and control groups. Expression of full-length and truncated TrkB was increased in rats with epilepsy, and physical exercise restored its expression to control levels. RAC-alpha serine/threonine-protein kinase, mammalian target of rapamycin, and extracellular signal-regulated kinase activation were reduced in rats with epilepsy, and exercise increased activation compared with control and epilepsy groups. Increased cAMP response element binding protein activation was observed in the exercise group compared with the epilepsy group. Our findings indicate that the beneficial effects of exercise in the epileptic brain can be in part related to alterations in the activation of proteins related to the BDNF-TrkB signaling pathway.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Fundacao de Amparo a Pesquisa do Estado de Sao PauloPrograma Nucleos de Excelencia (FAPESP-MCT/CNPq-PRONEX)Univ Fed Sao Paulo, Dept Fisiol, Rua Botucatu 862,Ed Ciencias Biomed,5 Andar, BR-04023900 Sao Paulo, SP, Brazilnst Fed Goiano, Campus Ceres, Ceres, BrazilHosp Israelita Albert Einstein, Sao Paulo, BrazilUniv Mogi das Cruzes, Mogi Das Cruzes, BrazilSanta Casa Sao Paulo, Fac Ciencias Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Fisiol, Rua Botucatu 862,Ed Ciencias Biomed,5 Andar, BR-04023900 Sao Paulo, SP, BrazilCNPq: 300605/2013-07FAPESP: 14/00035-1FAPESP: 2013/12692-4FAPESP: 2013/13725-3Nucleos de Excelencia: 2011/50680-2Web of Science911-920engWileyJournal Of Neuroscience ResearchBDNFcell signalingepilepsyphysical exercisePhysical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHobokenv. 965info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/556182021-09-30 17:31:41.739metadata only accessoai:repositorio.unifesp.br:11600/55618Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:26:44.647842Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.en.fl_str_mv |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy |
| title |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy |
| spellingShingle |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy Almeida, Alexandre Aparecido de [UNIFESP] BDNF cell signaling epilepsy physical exercise |
| title_short |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy |
| title_full |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy |
| title_fullStr |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy |
| title_full_unstemmed |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy |
| title_sort |
Physical exercise alters the activation of downstream proteins related to BDNF-TrkB signaling in male Wistar rats with epilepsy |
| author |
Almeida, Alexandre Aparecido de [UNIFESP] |
| author_facet |
Almeida, Alexandre Aparecido de [UNIFESP] Silva, Sergio Gomes da Lopim, Glauber Menezes [UNIFESP] Campos, Diego Vannucci [UNIFESP] Fernandes, Jansen [UNIFESP] Cabral, Francisco Romero Arida, Ricardo Mario [UNIFESP] |
| author_role |
author |
| author2 |
Silva, Sergio Gomes da Lopim, Glauber Menezes [UNIFESP] Campos, Diego Vannucci [UNIFESP] Fernandes, Jansen [UNIFESP] Cabral, Francisco Romero Arida, Ricardo Mario [UNIFESP] |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Alexandre Aparecido de [UNIFESP] Silva, Sergio Gomes da Lopim, Glauber Menezes [UNIFESP] Campos, Diego Vannucci [UNIFESP] Fernandes, Jansen [UNIFESP] Cabral, Francisco Romero Arida, Ricardo Mario [UNIFESP] |
| dc.subject.eng.fl_str_mv |
BDNF cell signaling epilepsy physical exercise |
| topic |
BDNF cell signaling epilepsy physical exercise |
| description |
There are a considerable number of studies concerning the behavioral effects of physical exercise on the epileptic brain |
| publishDate |
2018 |
| dc.date.issued.fl_str_mv |
2018 |
| dc.date.accessioned.fl_str_mv |
2020-07-20T16:30:58Z |
| dc.date.available.fl_str_mv |
2020-07-20T16:30:58Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
Journal Of Neuroscience Research. Hoboken, v. 96, n. 5, p. 911-920, 2018. |
| dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/55618 http://dx.doi.org/10.1002/jnr.24196 |
| dc.identifier.issn.none.fl_str_mv |
0360-4012 |
| dc.identifier.doi.none.fl_str_mv |
10.1002/jnr.24196 |
| dc.identifier.wos.none.fl_str_mv |
WOS:000427481100016 |
| identifier_str_mv |
Journal Of Neuroscience Research. Hoboken, v. 96, n. 5, p. 911-920, 2018. 0360-4012 10.1002/jnr.24196 WOS:000427481100016 |
| url |
https://repositorio.unifesp.br/handle/11600/55618 http://dx.doi.org/10.1002/jnr.24196 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Journal Of Neuroscience Research |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
911-920 |
| dc.coverage.none.fl_str_mv |
Hoboken |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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|
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1783460291432939520 |