Host kinin B1 receptor plays a protective role against melanoma progression
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/57964 http://dx.doi.org/10.1038/srep22078 |
Resumo: | Melanoma is a very aggressive tumor that arises from melanocytes. Late stage and widely spread diseases do not respond to standard therapeutic approaches. The kallikrein-kinin system (KKS) participates in biological processes such as vasodilatation, pain and inflammatory response. However, the role of KKS in tumor formation and progression is not completely understood. The role of the host kinin B1 receptor in melanoma development was evaluated using a syngeneic melanoma model. Primary tumors and metastasis were respectively induced by injecting B16F10 melanoma cells, which are derived from C57BL/6 mice, subcutaneously or in the tail vein in wild type C57BL/6 and B1 receptor knockout mice (B1(-/-)). Tumors developed in B1(-/-) mice presented unfavorable prognostic factors such as increased incidence of ulceration, higher levels of IL-10, higher activation of proliferative pathways such as ERK1/2 and Akt, and increased mitotic index. Furthermore, in the metastasis model, B1(-/-) mice developed larger metastatic colonies in the lung and lower CD8(+) immune effector cells when compared with WT animals. Altogether, our results provide evidences that B1(-/-) animals developed primary tumors with multiple features associated with poor prognosis and unfavorable metastatic onset, indicating that the B1 receptor may contribute to improve the host response against melanoma progression. |
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Maria, Andrea G.Dillenburg-Pilla, PatriciaReis, Rosana I.Floriano, Elaine M.Tefe-Silva, CristianeRamos, Simone G.Pesquero, Joao B. [UNIFESP]Nahmias, ClaraCosta-Neto, Claudio M.2020-08-21T17:00:22Z2020-08-21T17:00:22Z2016Scientific Reports. London, v. 6, p. -, 2016.2045-2322https://repositorio.unifesp.br/handle/11600/57964http://dx.doi.org/10.1038/srep22078WOS000370518700001.pdf10.1038/srep22078WOS:000370518700001Melanoma is a very aggressive tumor that arises from melanocytes. Late stage and widely spread diseases do not respond to standard therapeutic approaches. The kallikrein-kinin system (KKS) participates in biological processes such as vasodilatation, pain and inflammatory response. However, the role of KKS in tumor formation and progression is not completely understood. The role of the host kinin B1 receptor in melanoma development was evaluated using a syngeneic melanoma model. Primary tumors and metastasis were respectively induced by injecting B16F10 melanoma cells, which are derived from C57BL/6 mice, subcutaneously or in the tail vein in wild type C57BL/6 and B1 receptor knockout mice (B1(-/-)). Tumors developed in B1(-/-) mice presented unfavorable prognostic factors such as increased incidence of ulceration, higher levels of IL-10, higher activation of proliferative pathways such as ERK1/2 and Akt, and increased mitotic index. Furthermore, in the metastasis model, B1(-/-) mice developed larger metastatic colonies in the lung and lower CD8(+) immune effector cells when compared with WT animals. Altogether, our results provide evidences that B1(-/-) animals developed primary tumors with multiple features associated with poor prognosis and unfavorable metastatic onset, indicating that the B1 receptor may contribute to improve the host response against melanoma progression.Sao Paulo State Research Foundation (FAPESP)FAPESPUniv Sao Paulo, Dep Biochem & Immunol, BR-14049900 Ribeirao Preto, BrazilUniv Sao Paulo, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, BrazilUniv Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol, BR-14049900 Ribeirao Preto, BrazilUniv Fed Sao Paulo, Dept Biophys, BR-04039032 Sao Paulo, BrazilInst Gustave Roussy, INSERM, U981, F-94800 Villejuif, FranceUniv Fed Sao Paulo, Dept Biophys, BR-04039032 Sao Paulo, BrazilFAPESP: 2010/13346-4FAPESP: 2012/20148-0FAPESP: 2011/02144-4Web of Science-engNature Publishing GroupScientific ReportsHost kinin B1 receptor plays a protective role against melanoma progressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondon6info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000370518700001.pdfapplication/pdf5409503${dspace.ui.url}/bitstream/11600/57964/1/WOS000370518700001.pdfb7f50f89593d9b19bdbb85da45e69c9dMD51open accessTEXTWOS000370518700001.pdf.txtWOS000370518700001.pdf.txtExtracted texttext/plain45951${dspace.ui.url}/bitstream/11600/57964/2/WOS000370518700001.pdf.txt8812a5678ee28c6e917f9de1fa53a580MD52open accessTHUMBNAILWOS000370518700001.pdf.jpgWOS000370518700001.pdf.jpgIM Thumbnailimage/jpeg7356${dspace.ui.url}/bitstream/11600/57964/4/WOS000370518700001.pdf.jpg465c7ab765e48858152582550068bb78MD54open access11600/579642022-07-31 19:27:35.779open accessoai:repositorio.unifesp.br:11600/57964Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:19:40.464585Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Host kinin B1 receptor plays a protective role against melanoma progression |
title |
Host kinin B1 receptor plays a protective role against melanoma progression |
spellingShingle |
Host kinin B1 receptor plays a protective role against melanoma progression Maria, Andrea G. |
title_short |
Host kinin B1 receptor plays a protective role against melanoma progression |
title_full |
Host kinin B1 receptor plays a protective role against melanoma progression |
title_fullStr |
Host kinin B1 receptor plays a protective role against melanoma progression |
title_full_unstemmed |
Host kinin B1 receptor plays a protective role against melanoma progression |
title_sort |
Host kinin B1 receptor plays a protective role against melanoma progression |
author |
Maria, Andrea G. |
author_facet |
Maria, Andrea G. Dillenburg-Pilla, Patricia Reis, Rosana I. Floriano, Elaine M. Tefe-Silva, Cristiane Ramos, Simone G. Pesquero, Joao B. [UNIFESP] Nahmias, Clara Costa-Neto, Claudio M. |
author_role |
author |
author2 |
Dillenburg-Pilla, Patricia Reis, Rosana I. Floriano, Elaine M. Tefe-Silva, Cristiane Ramos, Simone G. Pesquero, Joao B. [UNIFESP] Nahmias, Clara Costa-Neto, Claudio M. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Maria, Andrea G. Dillenburg-Pilla, Patricia Reis, Rosana I. Floriano, Elaine M. Tefe-Silva, Cristiane Ramos, Simone G. Pesquero, Joao B. [UNIFESP] Nahmias, Clara Costa-Neto, Claudio M. |
description |
Melanoma is a very aggressive tumor that arises from melanocytes. Late stage and widely spread diseases do not respond to standard therapeutic approaches. The kallikrein-kinin system (KKS) participates in biological processes such as vasodilatation, pain and inflammatory response. However, the role of KKS in tumor formation and progression is not completely understood. The role of the host kinin B1 receptor in melanoma development was evaluated using a syngeneic melanoma model. Primary tumors and metastasis were respectively induced by injecting B16F10 melanoma cells, which are derived from C57BL/6 mice, subcutaneously or in the tail vein in wild type C57BL/6 and B1 receptor knockout mice (B1(-/-)). Tumors developed in B1(-/-) mice presented unfavorable prognostic factors such as increased incidence of ulceration, higher levels of IL-10, higher activation of proliferative pathways such as ERK1/2 and Akt, and increased mitotic index. Furthermore, in the metastasis model, B1(-/-) mice developed larger metastatic colonies in the lung and lower CD8(+) immune effector cells when compared with WT animals. Altogether, our results provide evidences that B1(-/-) animals developed primary tumors with multiple features associated with poor prognosis and unfavorable metastatic onset, indicating that the B1 receptor may contribute to improve the host response against melanoma progression. |
publishDate |
2016 |
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2016 |
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2020-08-21T17:00:22Z |
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Scientific Reports. London, v. 6, p. -, 2016. |
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https://repositorio.unifesp.br/handle/11600/57964 http://dx.doi.org/10.1038/srep22078 |
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2045-2322 |
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Scientific Reports. London, v. 6, p. -, 2016. 2045-2322 WOS000370518700001.pdf 10.1038/srep22078 WOS:000370518700001 |
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