Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37331 http://dx.doi.org/10.1371/journal.pone.0087784 |
Resumo: | Cross-reactivity of Fusarium species with serum galactomannan antigen (GMI) test has been observed. We sought to evaluate if GMI could help to early diagnose invasive fusariosis and to monitor treatment response. We reviewed the records of all patients with invasive fusariosis between 2008 and 2012 in three Brazilian hospitals. We selected patients who had at least 1 GMI test within 2 days before or after the date of the first clinical manifestation of fusariosis, and analyzed the temporal relationship between the first positive GMI test and the date of the diagnosis of invasive fusariosis, and the kinetics of GMI in relation to patients' response to treatment. We also selected 18 controls to determine the sensitivity and specificity of the test. Among 18 patients, 15 (83%) had at least one positive GMI (median 4, range 1-15). the sensitivity and specificity of was 83% and 67%, respectively. GMI was positive before the diagnosis of invasive fusariosis in 11 of the 15 cases (73%), at a median of 10 days (range 3-39), and after the diagnosis in 4 cases. GMI became negative in 8 of the 15 patients; 3 of these 8 patients (37.5%) were alive 90 days after the diagnosis of fusariosis compared with 2 of 7 (29%) who did not normalize GMI (p = 1.0). GMI is frequently positive in invasive fusariosis, and becomes positive before diagnosis in most patients. These findings may have important implications for the choice of antifungal therapy in settings with high prevalence of invasive fusariosis. |
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Nucci, MarcioCarlesse, Fabianne [UNIFESP]Cappellano, Paola [UNIFESP]Varon, Andrea G.Seber, Adriana [UNIFESP]Garnica, MarciaNouer, Simone A.Colombo, Arnaldo Lopes [UNIFESP]Universidade Federal do Rio de Janeiro (UFRJ)Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:35:10Z2016-01-24T14:35:10Z2014-01-28Plos One. San Francisco: Public Library Science, v. 9, n. 1, 5 p., 2014.1932-6203http://repositorio.unifesp.br/handle/11600/37331http://dx.doi.org/10.1371/journal.pone.0087784WOS000330510000149.pdf10.1371/journal.pone.0087784WOS:000330510000149Cross-reactivity of Fusarium species with serum galactomannan antigen (GMI) test has been observed. We sought to evaluate if GMI could help to early diagnose invasive fusariosis and to monitor treatment response. We reviewed the records of all patients with invasive fusariosis between 2008 and 2012 in three Brazilian hospitals. We selected patients who had at least 1 GMI test within 2 days before or after the date of the first clinical manifestation of fusariosis, and analyzed the temporal relationship between the first positive GMI test and the date of the diagnosis of invasive fusariosis, and the kinetics of GMI in relation to patients' response to treatment. We also selected 18 controls to determine the sensitivity and specificity of the test. Among 18 patients, 15 (83%) had at least one positive GMI (median 4, range 1-15). the sensitivity and specificity of was 83% and 67%, respectively. GMI was positive before the diagnosis of invasive fusariosis in 11 of the 15 cases (73%), at a median of 10 days (range 3-39), and after the diagnosis in 4 cases. GMI became negative in 8 of the 15 patients; 3 of these 8 patients (37.5%) were alive 90 days after the diagnosis of fusariosis compared with 2 of 7 (29%) who did not normalize GMI (p = 1.0). GMI is frequently positive in invasive fusariosis, and becomes positive before diagnosis in most patients. These findings may have important implications for the choice of antifungal therapy in settings with high prevalence of invasive fusariosis.Univ Fed Rio de Janeiro, Univ Hosp, Rio de Janeiro, BrazilUniversidade Federal de São Paulo UNIFESP, Inst Pediat Oncol GRAACC, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Univ Hosp, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Inst Pediat Oncol GRAACC, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Univ Hosp, São Paulo, BrazilWeb of Science5engPublic Library SciencePlos OneEarlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000330510000149.pdfapplication/pdf141804${dspace.ui.url}/bitstream/11600/37331/1/WOS000330510000149.pdfb34be5c6eeef42543a68b0c9de474d37MD51open accessTEXTWOS000330510000149.pdf.txtWOS000330510000149.pdf.txtExtracted texttext/plain30875${dspace.ui.url}/bitstream/11600/37331/21/WOS000330510000149.pdf.txt24857365fafb3b5cbbb553683010b1b7MD521open accessTHUMBNAILWOS000330510000149.pdf.jpgWOS000330510000149.pdf.jpgIM Thumbnailimage/jpeg7758${dspace.ui.url}/bitstream/11600/37331/23/WOS000330510000149.pdf.jpg123a77642280f475b779b33320ea59d9MD523open access11600/373312023-06-05 20:05:33.047open accessoai:repositorio.unifesp.br:11600/37331Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T23:05:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing |
title |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing |
spellingShingle |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing Nucci, Marcio |
title_short |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing |
title_full |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing |
title_fullStr |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing |
title_full_unstemmed |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing |
title_sort |
Earlier Diagnosis of Invasive Fusariosis with Aspergillus Serum Galactomannan Testing |
author |
Nucci, Marcio |
author_facet |
Nucci, Marcio Carlesse, Fabianne [UNIFESP] Cappellano, Paola [UNIFESP] Varon, Andrea G. Seber, Adriana [UNIFESP] Garnica, Marcia Nouer, Simone A. Colombo, Arnaldo Lopes [UNIFESP] |
author_role |
author |
author2 |
Carlesse, Fabianne [UNIFESP] Cappellano, Paola [UNIFESP] Varon, Andrea G. Seber, Adriana [UNIFESP] Garnica, Marcia Nouer, Simone A. Colombo, Arnaldo Lopes [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal do Rio de Janeiro (UFRJ) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Nucci, Marcio Carlesse, Fabianne [UNIFESP] Cappellano, Paola [UNIFESP] Varon, Andrea G. Seber, Adriana [UNIFESP] Garnica, Marcia Nouer, Simone A. Colombo, Arnaldo Lopes [UNIFESP] |
description |
Cross-reactivity of Fusarium species with serum galactomannan antigen (GMI) test has been observed. We sought to evaluate if GMI could help to early diagnose invasive fusariosis and to monitor treatment response. We reviewed the records of all patients with invasive fusariosis between 2008 and 2012 in three Brazilian hospitals. We selected patients who had at least 1 GMI test within 2 days before or after the date of the first clinical manifestation of fusariosis, and analyzed the temporal relationship between the first positive GMI test and the date of the diagnosis of invasive fusariosis, and the kinetics of GMI in relation to patients' response to treatment. We also selected 18 controls to determine the sensitivity and specificity of the test. Among 18 patients, 15 (83%) had at least one positive GMI (median 4, range 1-15). the sensitivity and specificity of was 83% and 67%, respectively. GMI was positive before the diagnosis of invasive fusariosis in 11 of the 15 cases (73%), at a median of 10 days (range 3-39), and after the diagnosis in 4 cases. GMI became negative in 8 of the 15 patients; 3 of these 8 patients (37.5%) were alive 90 days after the diagnosis of fusariosis compared with 2 of 7 (29%) who did not normalize GMI (p = 1.0). GMI is frequently positive in invasive fusariosis, and becomes positive before diagnosis in most patients. These findings may have important implications for the choice of antifungal therapy in settings with high prevalence of invasive fusariosis. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-28 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:35:10Z |
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2016-01-24T14:35:10Z |
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info:eu-repo/semantics/article |
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dc.identifier.citation.fl_str_mv |
Plos One. San Francisco: Public Library Science, v. 9, n. 1, 5 p., 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37331 http://dx.doi.org/10.1371/journal.pone.0087784 |
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1932-6203 |
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WOS000330510000149.pdf |
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10.1371/journal.pone.0087784 |
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Plos One. San Francisco: Public Library Science, v. 9, n. 1, 5 p., 2014. 1932-6203 WOS000330510000149.pdf 10.1371/journal.pone.0087784 WOS:000330510000149 |
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http://repositorio.unifesp.br/handle/11600/37331 http://dx.doi.org/10.1371/journal.pone.0087784 |
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