Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients

Detalhes bibliográficos
Autor(a) principal: Negri, Clara E. [UNIFESP]
Data de Publicação: 2017
Outros Autores: Goncalves, Sarah S., Sousa, Ana Cristina P. [UNIFESP], Bergamasco, Maria Daniela [UNIFESP], Martino, Marines D. V., Queiroz-Telles, Flavio, Aquino, Valerio Rodrigues, Castro, Paulo de Tarso O., Hagen, Ferry, Meis, Jacques F., Colombo, Arnaldo L. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/58281
http://dx.doi.org/10.1128/AAC.00608-17
Resumo: Aspergillus fumigatus azole resistance has emerged as a global health problem. We evaluated the in vitro antifungal susceptibility of 221 clinical A. fumigatus isolates according to CLSI guidelines. Sixty-one isolates exhibiting MICs at the epidemiological cutoff value (ECV) for itraconazole or above the ECV for any triazole were checked for CYP51A mutations. No mutations were documented, even for the isolates (1.8%) with high voriconazole MICs, indicating that triazoles may be used safely to treat aspergillosis in Brazil.
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spelling Negri, Clara E. [UNIFESP]Goncalves, Sarah S.Sousa, Ana Cristina P. [UNIFESP]Bergamasco, Maria Daniela [UNIFESP]Martino, Marines D. V.Queiroz-Telles, FlavioAquino, Valerio RodriguesCastro, Paulo de Tarso O.Hagen, FerryMeis, Jacques F.Colombo, Arnaldo L. [UNIFESP]2020-09-01T13:21:28Z2020-09-01T13:21:28Z2017Antimicrobial Agents And Chemotherapy. Washington, v. 61, n. 11, p. -, 2017.0066-4804https://repositorio.unifesp.br/handle/11600/58281http://dx.doi.org/10.1128/AAC.00608-1710.1128/AAC.00608-17WOS:000413558300027Aspergillus fumigatus azole resistance has emerged as a global health problem. We evaluated the in vitro antifungal susceptibility of 221 clinical A. fumigatus isolates according to CLSI guidelines. Sixty-one isolates exhibiting MICs at the epidemiological cutoff value (ECV) for itraconazole or above the ECV for any triazole were checked for CYP51A mutations. No mutations were documented, even for the isolates (1.8%) with high voriconazole MICs, indicating that triazoles may be used safely to treat aspergillosis in Brazil.Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), BrazilFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), BrazilConselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil (CNPq)CAPES-PROEXCAPES-PDSECAPES, BrazilCAPES-DSAstellasBasileaMerckUnited MedicalGilead SciencesCNPQGileadPfizerUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Infectol, Lab Especial Micol, Sao Paulo, SP, BrazilUniv Fed Espirito Santo, Dept Patol, CIMM, Vitoria, ES, BrazilHosp Israelita Albert Einstein, Sao Paulo, BrazilUniv Fed Parana, Hosp Clin, Dept Publ Hlth, Div Infect Dis, Curitiba, Parana, BrazilUniv Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, BrazilHosp Canc Barretos, Sao Paulo, BrazilCanisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, NetherlandsCtr Expertise Mycol Radboudumc CWZ, Nijmegen, NetherlandsUniv Fed Sao Paulo, Escola Paulista Med, Disciplina Infectol, Lab Especial Micol, Sao Paulo, SP, BrazilCAPES: AUX-PE-PNPD-2312/2011FAPESP: 2012/01138-4CNPq: 307510/2015-8CAPES-PDSE: 99999.008426/2014-07CAPES: PNPD 23038.007393/2011-1109Web of Science-engAmer Soc MicrobiologyAntimicrobial Agents And ChemotherapyA. fumigatusinvasive aspergillosistriazole resistanceantifungal resistanceBrazilTriazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleWashington6111info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/582812021-10-05 22:08:45.52metadata only accessoai:repositorio.unifesp.br:11600/58281Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:18:34.761205Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
title Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
spellingShingle Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
Negri, Clara E. [UNIFESP]
A. fumigatus
invasive aspergillosis
triazole resistance
antifungal resistance
Brazil
title_short Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
title_full Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
title_fullStr Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
title_full_unstemmed Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
title_sort Triazole Resistance Is Still Not Emerging in Aspergillus fumigatus Isolates Causing Invasive Aspergillosis in Brazilian Patients
author Negri, Clara E. [UNIFESP]
author_facet Negri, Clara E. [UNIFESP]
Goncalves, Sarah S.
Sousa, Ana Cristina P. [UNIFESP]
Bergamasco, Maria Daniela [UNIFESP]
Martino, Marines D. V.
Queiroz-Telles, Flavio
Aquino, Valerio Rodrigues
Castro, Paulo de Tarso O.
Hagen, Ferry
Meis, Jacques F.
Colombo, Arnaldo L. [UNIFESP]
author_role author
author2 Goncalves, Sarah S.
Sousa, Ana Cristina P. [UNIFESP]
Bergamasco, Maria Daniela [UNIFESP]
Martino, Marines D. V.
Queiroz-Telles, Flavio
Aquino, Valerio Rodrigues
Castro, Paulo de Tarso O.
Hagen, Ferry
Meis, Jacques F.
Colombo, Arnaldo L. [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Negri, Clara E. [UNIFESP]
Goncalves, Sarah S.
Sousa, Ana Cristina P. [UNIFESP]
Bergamasco, Maria Daniela [UNIFESP]
Martino, Marines D. V.
Queiroz-Telles, Flavio
Aquino, Valerio Rodrigues
Castro, Paulo de Tarso O.
Hagen, Ferry
Meis, Jacques F.
Colombo, Arnaldo L. [UNIFESP]
dc.subject.eng.fl_str_mv A. fumigatus
invasive aspergillosis
triazole resistance
antifungal resistance
Brazil
topic A. fumigatus
invasive aspergillosis
triazole resistance
antifungal resistance
Brazil
description Aspergillus fumigatus azole resistance has emerged as a global health problem. We evaluated the in vitro antifungal susceptibility of 221 clinical A. fumigatus isolates according to CLSI guidelines. Sixty-one isolates exhibiting MICs at the epidemiological cutoff value (ECV) for itraconazole or above the ECV for any triazole were checked for CYP51A mutations. No mutations were documented, even for the isolates (1.8%) with high voriconazole MICs, indicating that triazoles may be used safely to treat aspergillosis in Brazil.
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2020-09-01T13:21:28Z
dc.date.available.fl_str_mv 2020-09-01T13:21:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Antimicrobial Agents And Chemotherapy. Washington, v. 61, n. 11, p. -, 2017.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/58281
http://dx.doi.org/10.1128/AAC.00608-17
dc.identifier.issn.none.fl_str_mv 0066-4804
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.00608-17
dc.identifier.wos.none.fl_str_mv WOS:000413558300027
identifier_str_mv Antimicrobial Agents And Chemotherapy. Washington, v. 61, n. 11, p. -, 2017.
0066-4804
10.1128/AAC.00608-17
WOS:000413558300027
url https://repositorio.unifesp.br/handle/11600/58281
http://dx.doi.org/10.1128/AAC.00608-17
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Antimicrobial Agents And Chemotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
dc.coverage.none.fl_str_mv Washington
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
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