Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36334 http://dx.doi.org/10.1371/journal.pone.0063520 |
Resumo: | Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. in the present study we sought to examine whether manipulations of corticosterone levels during REM sleep deprivation would alter the subsequent sleep rebound. Adult male Wistar rats were fit with electrodes for sleep monitoring and submitted to four days of REM sleep deprivation under repeated corticosterone or metyrapone (an inhibitor of corticosterone synthesis) administration. Sleep parameters were continuously recorded throughout the sleep deprivation period and during 3 days of sleep recovery. Plasma levels of adrenocorticotropic hormone and corticosterone were also evaluated. Metyrapone treatment prevented the elevation of corticosterone plasma levels induced by REM sleep deprivation, whereas corticosterone administration to REM sleep-deprived rats resulted in lower corticosterone levels than in non-sleep deprived rats. Nonetheless, both corticosterone and metyrapone administration led to several alterations on sleep homeostasis, including reductions in the amount of non-REM and REM sleep during the recovery period, although corticosterone increased delta activity (1.0-4.0 Hz) during REM sleep deprivation. Metyrapone treatment of REM sleep-deprived rats reduced the number of REM sleep episodes. in conclusion, reduction of corticosterone levels during REM sleep deprivation resulted in impairment of sleep rebound, suggesting that physiological elevation of corticosterone levels resulting from REM sleep deprivation is necessary for plentiful recovery of sleep after this stressful event. |
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Machado, Ricardo Borges [UNIFESP]Tufik, Sergio [UNIFESP]Suchecki, Deborah [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:31:45Z2016-01-24T14:31:45Z2013-05-07Plos One. San Francisco: Public Library Science, v. 8, n. 5, 10 p., 2013.1932-6203http://repositorio.unifesp.br/handle/11600/36334http://dx.doi.org/10.1371/journal.pone.0063520WOS000319654700155.pdf10.1371/journal.pone.0063520WOS:000319654700155Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. in the present study we sought to examine whether manipulations of corticosterone levels during REM sleep deprivation would alter the subsequent sleep rebound. Adult male Wistar rats were fit with electrodes for sleep monitoring and submitted to four days of REM sleep deprivation under repeated corticosterone or metyrapone (an inhibitor of corticosterone synthesis) administration. Sleep parameters were continuously recorded throughout the sleep deprivation period and during 3 days of sleep recovery. Plasma levels of adrenocorticotropic hormone and corticosterone were also evaluated. Metyrapone treatment prevented the elevation of corticosterone plasma levels induced by REM sleep deprivation, whereas corticosterone administration to REM sleep-deprived rats resulted in lower corticosterone levels than in non-sleep deprived rats. Nonetheless, both corticosterone and metyrapone administration led to several alterations on sleep homeostasis, including reductions in the amount of non-REM and REM sleep during the recovery period, although corticosterone increased delta activity (1.0-4.0 Hz) during REM sleep deprivation. Metyrapone treatment of REM sleep-deprived rats reduced the number of REM sleep episodes. in conclusion, reduction of corticosterone levels during REM sleep deprivation resulted in impairment of sleep rebound, suggesting that physiological elevation of corticosterone levels resulting from REM sleep deprivation is necessary for plentiful recovery of sleep after this stressful event.Associacao Fundo de Incentivo a Pesquisa (AFIP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilFAPESP: 98/14303-3FAPESP: 04/02213-2Web of Science10engPublic Library SciencePlos OneRole of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000319654700155.pdfapplication/pdf1694188${dspace.ui.url}/bitstream/11600/36334/1/WOS000319654700155.pdf86749376de191818a7285e90866cc0a8MD51open accessTEXTWOS000319654700155.pdf.txtWOS000319654700155.pdf.txtExtracted texttext/plain54719${dspace.ui.url}/bitstream/11600/36334/2/WOS000319654700155.pdf.txt8596f304162b288f5f2969e4017f93d4MD52open access11600/363342023-01-30 22:17:45.573open accessoai:repositorio.unifesp.br:11600/36334Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:44:27.938487Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats |
title |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats |
spellingShingle |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats Machado, Ricardo Borges [UNIFESP] |
title_short |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats |
title_full |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats |
title_fullStr |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats |
title_full_unstemmed |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats |
title_sort |
Role of Corticosterone on Sleep Homeostasis Induced by REM Sleep Deprivation in Rats |
author |
Machado, Ricardo Borges [UNIFESP] |
author_facet |
Machado, Ricardo Borges [UNIFESP] Tufik, Sergio [UNIFESP] Suchecki, Deborah [UNIFESP] |
author_role |
author |
author2 |
Tufik, Sergio [UNIFESP] Suchecki, Deborah [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Machado, Ricardo Borges [UNIFESP] Tufik, Sergio [UNIFESP] Suchecki, Deborah [UNIFESP] |
description |
Sleep is regulated by humoral and homeostatic processes. If on one hand chronic elevation of stress hormones impair sleep, on the other hand, rapid eye movement (REM) sleep deprivation induces elevation of glucocorticoids and time of REM sleep during the recovery period. in the present study we sought to examine whether manipulations of corticosterone levels during REM sleep deprivation would alter the subsequent sleep rebound. Adult male Wistar rats were fit with electrodes for sleep monitoring and submitted to four days of REM sleep deprivation under repeated corticosterone or metyrapone (an inhibitor of corticosterone synthesis) administration. Sleep parameters were continuously recorded throughout the sleep deprivation period and during 3 days of sleep recovery. Plasma levels of adrenocorticotropic hormone and corticosterone were also evaluated. Metyrapone treatment prevented the elevation of corticosterone plasma levels induced by REM sleep deprivation, whereas corticosterone administration to REM sleep-deprived rats resulted in lower corticosterone levels than in non-sleep deprived rats. Nonetheless, both corticosterone and metyrapone administration led to several alterations on sleep homeostasis, including reductions in the amount of non-REM and REM sleep during the recovery period, although corticosterone increased delta activity (1.0-4.0 Hz) during REM sleep deprivation. Metyrapone treatment of REM sleep-deprived rats reduced the number of REM sleep episodes. in conclusion, reduction of corticosterone levels during REM sleep deprivation resulted in impairment of sleep rebound, suggesting that physiological elevation of corticosterone levels resulting from REM sleep deprivation is necessary for plentiful recovery of sleep after this stressful event. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-05-07 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:45Z |
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2016-01-24T14:31:45Z |
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Plos One. San Francisco: Public Library Science, v. 8, n. 5, 10 p., 2013. |
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http://repositorio.unifesp.br/handle/11600/36334 http://dx.doi.org/10.1371/journal.pone.0063520 |
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1932-6203 |
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WOS000319654700155.pdf |
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10.1371/journal.pone.0063520 |
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WOS:000319654700155 |
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Plos One. San Francisco: Public Library Science, v. 8, n. 5, 10 p., 2013. 1932-6203 WOS000319654700155.pdf 10.1371/journal.pone.0063520 WOS:000319654700155 |
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http://repositorio.unifesp.br/handle/11600/36334 http://dx.doi.org/10.1371/journal.pone.0063520 |
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