Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/4018 http://dx.doi.org/10.1590/S0100-879X2006005000184 |
Resumo: | The introduction of routine vaccination against tetanus and diphtheria in Brazil has decreased the incidence and changed the epidemiology of both diseases. We then investigated the prevalence of Corynebacterium diphtheriae carrier status and diphtheria and tetanus immunity in São Paulo, Brazil. From November 2001 to March 2003, 374 individuals were tested for the presence of C. diphtheriae in the naso-oropharynx and of serum diphtheria and tetanus antibodies. Participants were all healthy individuals without acute or chronic pathologies and they were stratified by age as follows: 0-12 months and 1-4, 5-9, 10-14, 15-24, 25-39, 40-59, and ³60 years. Antibodies were assessed using a double-antigen ELISA. C. diphtheriae species were identified by biochemical analysis and toxigenicity was assessed by the Elek test. For diphtheria, full protection (antibodies ³0.1 IU/mL) was present in 84% of the individuals, 15% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 1% were susceptible (antibodies <0.01 IU/mL). Full tetanus protection (antibodies ³0.1 IU/mL) was present in 79% of the participants, 18% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 3% were susceptible (antibodies <0.01 IU/mL). The geometric mean of diphtheria and tetanus antibodies reached the highest values at 5-9 years and decreased until the 40-59-year age range, increasing again in individuals over 60 years. Three participants (0.8%) were carriers of C. diphtheriae, all non-toxigenic strains. The present results demonstrate the clear need of periodic booster for tetanus and diphtheria vaccine in adolescents and adults after primary immunization in childhood. |
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Divino-Goes, K.g. [UNIFESP]De Moraes-Pinto, Maria Isabel [UNIFESP]Dinelli, Maria Isabel Saraiva [UNIFESP]Casagrande, Silvana TadeuBonetti, Tatiana Carvalho de Souza [UNIFESP]Andrade, P.r.Weckx, Lily Yin [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Instituto Adolfo LutzCentro Assistencial Cruz de Malta2015-06-14T13:37:12Z2015-06-14T13:37:12Z2007-12-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 12, p. 1681-1687, 2007.0100-879Xhttp://repositorio.unifesp.br/handle/11600/4018http://dx.doi.org/10.1590/S0100-879X2006005000184S0100-879X2007001200012.pdfS0100-879X200700120001210.1590/S0100-879X2006005000184WOS:000252843900012The introduction of routine vaccination against tetanus and diphtheria in Brazil has decreased the incidence and changed the epidemiology of both diseases. We then investigated the prevalence of Corynebacterium diphtheriae carrier status and diphtheria and tetanus immunity in São Paulo, Brazil. From November 2001 to March 2003, 374 individuals were tested for the presence of C. diphtheriae in the naso-oropharynx and of serum diphtheria and tetanus antibodies. Participants were all healthy individuals without acute or chronic pathologies and they were stratified by age as follows: 0-12 months and 1-4, 5-9, 10-14, 15-24, 25-39, 40-59, and ³60 years. Antibodies were assessed using a double-antigen ELISA. C. diphtheriae species were identified by biochemical analysis and toxigenicity was assessed by the Elek test. For diphtheria, full protection (antibodies ³0.1 IU/mL) was present in 84% of the individuals, 15% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 1% were susceptible (antibodies <0.01 IU/mL). Full tetanus protection (antibodies ³0.1 IU/mL) was present in 79% of the participants, 18% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 3% were susceptible (antibodies <0.01 IU/mL). The geometric mean of diphtheria and tetanus antibodies reached the highest values at 5-9 years and decreased until the 40-59-year age range, increasing again in individuals over 60 years. Three participants (0.8%) were carriers of C. diphtheriae, all non-toxigenic strains. The present results demonstrate the clear need of periodic booster for tetanus and diphtheria vaccine in adolescents and adults after primary immunization in childhood.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PediatriaInstituto Adolfo LutzCentro Assistencial Cruz de MaltaUNIFESP, EPM, Depto. de PediatriaSciELO1681-1687engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchDiphtheriaTetanusCorynebacterium diphtheriaeVaccineImmunizationAntibodyPrevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2007001200012.pdfapplication/pdf516559${dspace.ui.url}/bitstream/11600/4018/1/S0100-879X2007001200012.pdf3912195261107383ce5ca36355810793MD51open accessTEXTS0100-879X2007001200012.pdf.txtS0100-879X2007001200012.pdf.txtExtracted texttext/plain25565${dspace.ui.url}/bitstream/11600/4018/21/S0100-879X2007001200012.pdf.txt9b579fa88b7cefa32c3458aa7c8aef38MD521open accessTHUMBNAILS0100-879X2007001200012.pdf.jpgS0100-879X2007001200012.pdf.jpgIM Thumbnailimage/jpeg5714${dspace.ui.url}/bitstream/11600/4018/23/S0100-879X2007001200012.pdf.jpg4ff439b826231db7b04c41da1b24ec61MD523open access11600/40182023-06-05 20:20:32.766open accessoai:repositorio.unifesp.br:11600/4018Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T23:20:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil |
title |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil |
spellingShingle |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil Divino-Goes, K.g. [UNIFESP] Diphtheria Tetanus Corynebacterium diphtheriae Vaccine Immunization Antibody |
title_short |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil |
title_full |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil |
title_fullStr |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil |
title_full_unstemmed |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil |
title_sort |
Prevalence of diphtheria and tetanus antibodies and circulation of Corynebacterium diphtheriae in São Paulo, Brazil |
author |
Divino-Goes, K.g. [UNIFESP] |
author_facet |
Divino-Goes, K.g. [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] Dinelli, Maria Isabel Saraiva [UNIFESP] Casagrande, Silvana Tadeu Bonetti, Tatiana Carvalho de Souza [UNIFESP] Andrade, P.r. Weckx, Lily Yin [UNIFESP] |
author_role |
author |
author2 |
De Moraes-Pinto, Maria Isabel [UNIFESP] Dinelli, Maria Isabel Saraiva [UNIFESP] Casagrande, Silvana Tadeu Bonetti, Tatiana Carvalho de Souza [UNIFESP] Andrade, P.r. Weckx, Lily Yin [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Instituto Adolfo Lutz Centro Assistencial Cruz de Malta |
dc.contributor.author.fl_str_mv |
Divino-Goes, K.g. [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] Dinelli, Maria Isabel Saraiva [UNIFESP] Casagrande, Silvana Tadeu Bonetti, Tatiana Carvalho de Souza [UNIFESP] Andrade, P.r. Weckx, Lily Yin [UNIFESP] |
dc.subject.eng.fl_str_mv |
Diphtheria Tetanus Corynebacterium diphtheriae Vaccine Immunization Antibody |
topic |
Diphtheria Tetanus Corynebacterium diphtheriae Vaccine Immunization Antibody |
description |
The introduction of routine vaccination against tetanus and diphtheria in Brazil has decreased the incidence and changed the epidemiology of both diseases. We then investigated the prevalence of Corynebacterium diphtheriae carrier status and diphtheria and tetanus immunity in São Paulo, Brazil. From November 2001 to March 2003, 374 individuals were tested for the presence of C. diphtheriae in the naso-oropharynx and of serum diphtheria and tetanus antibodies. Participants were all healthy individuals without acute or chronic pathologies and they were stratified by age as follows: 0-12 months and 1-4, 5-9, 10-14, 15-24, 25-39, 40-59, and ³60 years. Antibodies were assessed using a double-antigen ELISA. C. diphtheriae species were identified by biochemical analysis and toxigenicity was assessed by the Elek test. For diphtheria, full protection (antibodies ³0.1 IU/mL) was present in 84% of the individuals, 15% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 1% were susceptible (antibodies <0.01 IU/mL). Full tetanus protection (antibodies ³0.1 IU/mL) was present in 79% of the participants, 18% had basic protection (antibodies ³0.01 and <0.1 IU/mL) and 3% were susceptible (antibodies <0.01 IU/mL). The geometric mean of diphtheria and tetanus antibodies reached the highest values at 5-9 years and decreased until the 40-59-year age range, increasing again in individuals over 60 years. Three participants (0.8%) were carriers of C. diphtheriae, all non-toxigenic strains. The present results demonstrate the clear need of periodic booster for tetanus and diphtheria vaccine in adolescents and adults after primary immunization in childhood. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-12-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:37:12Z |
dc.date.available.fl_str_mv |
2015-06-14T13:37:12Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 12, p. 1681-1687, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/4018 http://dx.doi.org/10.1590/S0100-879X2006005000184 |
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0100-879X |
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S0100-879X2007001200012.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2007001200012 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2006005000184 |
dc.identifier.wos.none.fl_str_mv |
WOS:000252843900012 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 12, p. 1681-1687, 2007. 0100-879X S0100-879X2007001200012.pdf S0100-879X2007001200012 10.1590/S0100-879X2006005000184 WOS:000252843900012 |
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http://repositorio.unifesp.br/handle/11600/4018 http://dx.doi.org/10.1590/S0100-879X2006005000184 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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openAccess |
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1681-1687 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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