Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis
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Publication Date: | 2013 |
Other Authors: | , , , , |
Format: | Article |
Language: | por |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/36665 http://dx.doi.org/10.1016/j.rppneu.2013.03.002 |
Summary: | Objective: To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis.Methodology: Samples of mucus were collected, from 21 volunteers presenting no lung disease who had undergone surgery, from 10 patients presenting chronic COPD, and from 16 patients with bronchiectasis. Mucociliary transport (MCT), transport by cough (SCM), and contact angle (CAM) were evaluated.Results: MCT was found to be greater in healthy individuals (1.0 +/- 0.19) than in COPD (0.91 +/- 0.17) and bronchiectasis (0.76 +/- 0.23) patients (p < 0.05), whereas SCM was greater in COPD patients (16.31 +/- 7.35 cm) than in patients with bronchiectasis (12.16 +/- 6.64 cm) and healthy individuals (10.50 +/- 25.8 cm) (p < 0.05). No significant differences were observed between the groups regarding CAM.Conclusion: Mucus from healthy individuals allows better mucociliary transport compared to that from patients with lung diseases. However, the mucus from COPD patients allows a better transport by coughing, demonstrating that these individuals have adapted to a defence mechanism compared to patients with bronchiectasis, who have impairment in their ciliary and cough transport mechanisms. (c) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved. |
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Afonso, Juliana LimaTambascio, JoanaSouza, Hugo Celso Dutra deJardim, José Roberto [UNIFESP]Martinez, José Antônio BaddiniGastaldi, Ada Clarice [UNIFESP]Ctr Univ TridnguloFac Med Ribeirao PretoUniversidade Federal de São Paulo (UNIFESP)2016-01-24T14:34:18Z2016-01-24T14:34:18Z2013-09-01Revista Portuguesa de Pneumologia. Barcelona: Elsevier Doyma Sl, v. 19, n. 5, p. 211-216, 2013.0873-2159http://repositorio.unifesp.br/handle/11600/36665http://dx.doi.org/10.1016/j.rppneu.2013.03.002WOS000325382700006.pdf10.1016/j.rppneu.2013.03.002WOS:000325382700006Objective: To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis.Methodology: Samples of mucus were collected, from 21 volunteers presenting no lung disease who had undergone surgery, from 10 patients presenting chronic COPD, and from 16 patients with bronchiectasis. Mucociliary transport (MCT), transport by cough (SCM), and contact angle (CAM) were evaluated.Results: MCT was found to be greater in healthy individuals (1.0 +/- 0.19) than in COPD (0.91 +/- 0.17) and bronchiectasis (0.76 +/- 0.23) patients (p < 0.05), whereas SCM was greater in COPD patients (16.31 +/- 7.35 cm) than in patients with bronchiectasis (12.16 +/- 6.64 cm) and healthy individuals (10.50 +/- 25.8 cm) (p < 0.05). No significant differences were observed between the groups regarding CAM.Conclusion: Mucus from healthy individuals allows better mucociliary transport compared to that from patients with lung diseases. However, the mucus from COPD patients allows a better transport by coughing, demonstrating that these individuals have adapted to a defence mechanism compared to patients with bronchiectasis, who have impairment in their ciliary and cough transport mechanisms. (c) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved.Ctr Univ Tridngulo, Dept Fisioterapia, Uberlandia, MG, BrazilFac Med Ribeirao Preto, Dept Fisioterapia, Ribeirao Preto, BrazilUniversidade Federal de São Paulo, Dept Pneumol, São Paulo, BrazilFac Med Ribeirao Preto, Dept Pneumol, Ribeirao Preto, BrazilUniversidade Federal de São Paulo, Dept Pneumol, São Paulo, BrazilWeb of Science211-216porElsevier B.V.Revista Portuguesa de Pneumologiahttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessCOPDBronchiectasisRespiratory mucusMucociliary clearanceTransport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000325382700006.pdfapplication/pdf340917${dspace.ui.url}/bitstream/11600/36665/1/WOS000325382700006.pdf4119f6076bb8ccad49cc9c6d14276929MD51open accessTEXTWOS000325382700006.pdf.txtWOS000325382700006.pdf.txtExtracted texttext/plain27521${dspace.ui.url}/bitstream/11600/36665/2/WOS000325382700006.pdf.txte636d2f175ea5fea4890e944910c8eabMD52open access11600/366652022-06-02 10:26:53.338open accessoai:repositorio.unifesp.br:11600/36665Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:17:11.541551Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis |
title |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis |
spellingShingle |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis Afonso, Juliana Lima COPD Bronchiectasis Respiratory mucus Mucociliary clearance |
title_short |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis |
title_full |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis |
title_fullStr |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis |
title_full_unstemmed |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis |
title_sort |
Transport of mucoid mucus in healthy individuals and patients with chronic obstructive pulmonary disease and bronchiectasis |
author |
Afonso, Juliana Lima |
author_facet |
Afonso, Juliana Lima Tambascio, Joana Souza, Hugo Celso Dutra de Jardim, José Roberto [UNIFESP] Martinez, José Antônio Baddini Gastaldi, Ada Clarice [UNIFESP] |
author_role |
author |
author2 |
Tambascio, Joana Souza, Hugo Celso Dutra de Jardim, José Roberto [UNIFESP] Martinez, José Antônio Baddini Gastaldi, Ada Clarice [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.institution.none.fl_str_mv |
Ctr Univ Tridngulo Fac Med Ribeirao Preto Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Afonso, Juliana Lima Tambascio, Joana Souza, Hugo Celso Dutra de Jardim, José Roberto [UNIFESP] Martinez, José Antônio Baddini Gastaldi, Ada Clarice [UNIFESP] |
dc.subject.eng.fl_str_mv |
COPD Bronchiectasis Respiratory mucus Mucociliary clearance |
topic |
COPD Bronchiectasis Respiratory mucus Mucociliary clearance |
description |
Objective: To characterise and compare the in vitro transport properties of respiratory mucoid secretion in individuals with no lung disease and in stable patients with chronic obstructive pulmonary disease (COPD) and bronchiectasis.Methodology: Samples of mucus were collected, from 21 volunteers presenting no lung disease who had undergone surgery, from 10 patients presenting chronic COPD, and from 16 patients with bronchiectasis. Mucociliary transport (MCT), transport by cough (SCM), and contact angle (CAM) were evaluated.Results: MCT was found to be greater in healthy individuals (1.0 +/- 0.19) than in COPD (0.91 +/- 0.17) and bronchiectasis (0.76 +/- 0.23) patients (p < 0.05), whereas SCM was greater in COPD patients (16.31 +/- 7.35 cm) than in patients with bronchiectasis (12.16 +/- 6.64 cm) and healthy individuals (10.50 +/- 25.8 cm) (p < 0.05). No significant differences were observed between the groups regarding CAM.Conclusion: Mucus from healthy individuals allows better mucociliary transport compared to that from patients with lung diseases. However, the mucus from COPD patients allows a better transport by coughing, demonstrating that these individuals have adapted to a defence mechanism compared to patients with bronchiectasis, who have impairment in their ciliary and cough transport mechanisms. (c) 2012 Sociedade Portuguesa de Pneumologia. Published by Elsevier Espana, S.L. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-09-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:18Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Revista Portuguesa de Pneumologia. Barcelona: Elsevier Doyma Sl, v. 19, n. 5, p. 211-216, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36665 http://dx.doi.org/10.1016/j.rppneu.2013.03.002 |
dc.identifier.issn.none.fl_str_mv |
0873-2159 |
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WOS000325382700006.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.rppneu.2013.03.002 |
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WOS:000325382700006 |
identifier_str_mv |
Revista Portuguesa de Pneumologia. Barcelona: Elsevier Doyma Sl, v. 19, n. 5, p. 211-216, 2013. 0873-2159 WOS000325382700006.pdf 10.1016/j.rppneu.2013.03.002 WOS:000325382700006 |
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http://repositorio.unifesp.br/handle/11600/36665 http://dx.doi.org/10.1016/j.rppneu.2013.03.002 |
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por |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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211-216 |
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Elsevier B.V. |
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Elsevier B.V. |
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