Cocristais: uma estratégia promissora na área farmacêutica

Detalhes bibliográficos
Autor(a) principal: Rocha, Alanny B. O.
Data de Publicação: 2016
Outros Autores: Kuminek, Gislaine, Machado, Tatiane C., Rosa, Juliana, Rauber, Gabriela S., Borba, Paola A. A., Siedler, Sana, Stulzer, Hellen K., Cuffini, Silvia Lucia [UNIFESP], Rodriguez-Hornedo, Nair, Cardoso, Simone G.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/56777
http://dx.doi.org/10.21577/0100-4042.20160139
Resumo: Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.
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spelling Rocha, Alanny B. O.Kuminek, GislaineMachado, Tatiane C.Rosa, JulianaRauber, Gabriela S.Borba, Paola A. A.Siedler, SanaStulzer, Hellen K.Cuffini, Silvia Lucia [UNIFESP]Rodriguez-Hornedo, NairCardoso, Simone G.2020-07-31T12:47:22Z2020-07-31T12:47:22Z2016Quimica Nova. Sao Paulo, v. 39, n. 9, p. 1112-1125, 2016.0100-4042https://repositorio.unifesp.br/handle/11600/56777http://dx.doi.org/10.21577/0100-4042.20160139S0100-40422016000901112.pdfS0100-4042201600090111210.21577/0100-4042.20160139WOS:000390207600012Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.Univ Fed Santa Catarina, Dept Ciencias Farmaceut, BR-88040970 Florianopolis, SC, BrazilUniv Fed Sao Paulo, Inst Ciencias & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, BrazilUniv Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USAUniv Cambridge, Dept Chem, Cambridge CB2 1EW, Cambs, EnglandMinist Educ, CAPES, BR-70040020 Brasilia, DF, BrazilInstituto de Ciências e Tecnologia, Universidade Federal de São Paulo, 12231-280 São José dos Campos – SP, BrasilWeb of Science1112-1125porSoc Brasileira QuimicaQuimica Novacocrystalsdrugsolubilitytransition pointthermodynamic stabilityCocristais: uma estratégia promissora na área farmacêuticaCocrystals: a promising strategy in pharmaceutical sciencesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo399info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-40422016000901112.pdfapplication/pdf3549611${dspace.ui.url}/bitstream/11600/56777/1/S0100-40422016000901112.pdf7bb65e375190acb0b53ec451b3af6920MD51open accessTEXTS0100-40422016000901112.pdf.txtS0100-40422016000901112.pdf.txtExtracted texttext/plain70003${dspace.ui.url}/bitstream/11600/56777/8/S0100-40422016000901112.pdf.txtd0639682032e17f94950ac3c2135e53cMD58open accessTHUMBNAILS0100-40422016000901112.pdf.jpgS0100-40422016000901112.pdf.jpgIM Thumbnailimage/jpeg6777${dspace.ui.url}/bitstream/11600/56777/10/S0100-40422016000901112.pdf.jpg072c88941d96d74ced462f67db0b9356MD510open access11600/567772023-06-05 19:10:43.299open accessoai:repositorio.unifesp.br:11600/56777Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:10:43Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.pt.fl_str_mv Cocristais: uma estratégia promissora na área farmacêutica
dc.title.alternative.en.fl_str_mv Cocrystals: a promising strategy in pharmaceutical sciences
title Cocristais: uma estratégia promissora na área farmacêutica
spellingShingle Cocristais: uma estratégia promissora na área farmacêutica
Rocha, Alanny B. O.
cocrystals
drug
solubility
transition point
thermodynamic stability
title_short Cocristais: uma estratégia promissora na área farmacêutica
title_full Cocristais: uma estratégia promissora na área farmacêutica
title_fullStr Cocristais: uma estratégia promissora na área farmacêutica
title_full_unstemmed Cocristais: uma estratégia promissora na área farmacêutica
title_sort Cocristais: uma estratégia promissora na área farmacêutica
author Rocha, Alanny B. O.
author_facet Rocha, Alanny B. O.
Kuminek, Gislaine
Machado, Tatiane C.
Rosa, Juliana
Rauber, Gabriela S.
Borba, Paola A. A.
Siedler, Sana
Stulzer, Hellen K.
Cuffini, Silvia Lucia [UNIFESP]
Rodriguez-Hornedo, Nair
Cardoso, Simone G.
author_role author
author2 Kuminek, Gislaine
Machado, Tatiane C.
Rosa, Juliana
Rauber, Gabriela S.
Borba, Paola A. A.
Siedler, Sana
Stulzer, Hellen K.
Cuffini, Silvia Lucia [UNIFESP]
Rodriguez-Hornedo, Nair
Cardoso, Simone G.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Alanny B. O.
Kuminek, Gislaine
Machado, Tatiane C.
Rosa, Juliana
Rauber, Gabriela S.
Borba, Paola A. A.
Siedler, Sana
Stulzer, Hellen K.
Cuffini, Silvia Lucia [UNIFESP]
Rodriguez-Hornedo, Nair
Cardoso, Simone G.
dc.subject.eng.fl_str_mv cocrystals
drug
solubility
transition point
thermodynamic stability
topic cocrystals
drug
solubility
transition point
thermodynamic stability
description Pharmaceutical cocrystals have emerged as a useful strategy to improve the aqueous solubility of poorly water soluble drugs by aiming to enhance their oral absorption and bioavailability. Aqueous cocrystal solubility can be orders of magnitude higher than that of the constituent drug and this solubility advantage can be fine-tuned based on environmental conditions such as pH and the presence of drug solubilizing agents. This review presents a brief overview of pharmaceutical cocrystals regarding cocrystal design, obtainment methods, with particular focus on cocrystal solubility, and the solubility modulation by solution phase chemistry.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2020-07-31T12:47:22Z
dc.date.available.fl_str_mv 2020-07-31T12:47:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Quimica Nova. Sao Paulo, v. 39, n. 9, p. 1112-1125, 2016.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/56777
http://dx.doi.org/10.21577/0100-4042.20160139
dc.identifier.issn.none.fl_str_mv 0100-4042
dc.identifier.file.none.fl_str_mv S0100-40422016000901112.pdf
dc.identifier.scielo.none.fl_str_mv S0100-40422016000901112
dc.identifier.doi.none.fl_str_mv 10.21577/0100-4042.20160139
dc.identifier.wos.none.fl_str_mv WOS:000390207600012
identifier_str_mv Quimica Nova. Sao Paulo, v. 39, n. 9, p. 1112-1125, 2016.
0100-4042
S0100-40422016000901112.pdf
S0100-40422016000901112
10.21577/0100-4042.20160139
WOS:000390207600012
url https://repositorio.unifesp.br/handle/11600/56777
http://dx.doi.org/10.21577/0100-4042.20160139
dc.language.iso.fl_str_mv por
language por
dc.relation.ispartof.none.fl_str_mv Quimica Nova
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1112-1125
dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Soc Brasileira Quimica
publisher.none.fl_str_mv Soc Brasileira Quimica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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