Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile
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Publication Date: | 2011 |
Other Authors: | , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/34163 http://dx.doi.org/10.1016/j.yebeh.2011.08.005 |
Summary: | We report the results of administration of the Portuguese-Brazilian translation of the Liverpool Adverse Events Profile (LAEP) to 100 patients (mean age = 34.5, SD = 12.12; 56 females), 61 with symptomatic partial epilepsy (SPE) and 39 with idiopathic generalized epilepsy (ICE) (ILAE, 1989) who were on a stable antiepileptic drug (AED) regimen and being treated in a Brazilian tertiary epilepsy center. Carbamazepine was the most commonly used AED (43.0%), followed by valproic acid (32.0%). Two or more AEDs were used by 69.0% of patients. the mean LAEP score (19 questions) was 37.6 (SD = 13.35). the most common adverse effects were sleepiness (35.0%), memory problems (35.0%), and difficulty in concentrating (25.0%). Higher LAEP scores were associated with polytherapy with three or more AEDs (P=0.005), female gender (P<0.001), older age (P<0.001), and uncontrolled seizures (P = 0.045). the intraclass coefficient (test-retest reliability) for LAEP overall score was 0.848 (95% CI = 0.782-0.895), with a range from 0.370 (unsteadiness) to 0.750 (memory problems). Cronbach's alpha coefficient (internal consistency) was 0.903. the LAEP was highly correlated with Quality of Life in Epilepsy-31 inventory (r = -0.804, P>0.001) and Hospital Anxiety and Depression Scale (Depression: r = 0.637, P<0.001; Anxiety: r = 0.621, P<0.001) dimensions. LAEP overall scores were similar in people with SPE and IGE and were not helpful in differentiating adverse effects in these two groups. Clinical variables that influenced global LAEP were seizure frequency (P = 0.050) and generalized tonic-clonic seizures in the last month (P = 0.031) in the ICE group, and polytherapy with three or more AEDs (P = 0.003 and P = 0.003) in both ICE and SPE groups. (C) 2011 Elsevier Inc. All rights reserved. |
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Martins, Heloise Helena [UNIFESP]Alonso, Neide Barreira [UNIFESP]Vidal-Dourado, Marcos [UNIFESP]Carbonel, Thiago Delfino [UNIFESP]Araujo Filho, Gerardo Maria de [UNIFESP]Caboclo, Luís Otávio Sales Ferreira [UNIFESP]Yacubian, Elza Márcia Targas [UNIFESP]Guilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:17:20Z2016-01-24T14:17:20Z2011-11-01Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 3, p. 511-517, 2011.1525-5050http://repositorio.unifesp.br/handle/11600/34163http://dx.doi.org/10.1016/j.yebeh.2011.08.005WOS000296826700017.pdf10.1016/j.yebeh.2011.08.005WOS:000296826700017We report the results of administration of the Portuguese-Brazilian translation of the Liverpool Adverse Events Profile (LAEP) to 100 patients (mean age = 34.5, SD = 12.12; 56 females), 61 with symptomatic partial epilepsy (SPE) and 39 with idiopathic generalized epilepsy (ICE) (ILAE, 1989) who were on a stable antiepileptic drug (AED) regimen and being treated in a Brazilian tertiary epilepsy center. Carbamazepine was the most commonly used AED (43.0%), followed by valproic acid (32.0%). Two or more AEDs were used by 69.0% of patients. the mean LAEP score (19 questions) was 37.6 (SD = 13.35). the most common adverse effects were sleepiness (35.0%), memory problems (35.0%), and difficulty in concentrating (25.0%). Higher LAEP scores were associated with polytherapy with three or more AEDs (P=0.005), female gender (P<0.001), older age (P<0.001), and uncontrolled seizures (P = 0.045). the intraclass coefficient (test-retest reliability) for LAEP overall score was 0.848 (95% CI = 0.782-0.895), with a range from 0.370 (unsteadiness) to 0.750 (memory problems). Cronbach's alpha coefficient (internal consistency) was 0.903. the LAEP was highly correlated with Quality of Life in Epilepsy-31 inventory (r = -0.804, P>0.001) and Hospital Anxiety and Depression Scale (Depression: r = 0.637, P<0.001; Anxiety: r = 0.621, P<0.001) dimensions. LAEP overall scores were similar in people with SPE and IGE and were not helpful in differentiating adverse effects in these two groups. Clinical variables that influenced global LAEP were seizure frequency (P = 0.050) and generalized tonic-clonic seizures in the last month (P = 0.031) in the ICE group, and polytherapy with three or more AEDs (P = 0.003 and P = 0.003) in both ICE and SPE groups. (C) 2011 Elsevier Inc. All rights reserved.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol, São Paulo, BrazilWeb of Science511-517engElsevier B.V.Epilepsy & Behaviorhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessLiverpool Adverse Events ProfileAntiepileptic drugsEpilepsyAdverse effectsSymptomatic partial epilepsyIdiopathic generalized epilepsyValidationAre adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profileinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000296826700017.pdfapplication/pdf666093${dspace.ui.url}/bitstream/11600/34163/1/WOS000296826700017.pdf97efb5d8765f4c10b92fbda30647b28eMD51open accessTEXTWOS000296826700017.pdf.txtWOS000296826700017.pdf.txtExtracted texttext/plain42154${dspace.ui.url}/bitstream/11600/34163/2/WOS000296826700017.pdf.txt961289cf601d60b8311afc52b5c1d5d1MD52open access11600/341632022-07-08 10:22:10.688open accessoai:repositorio.unifesp.br:11600/34163Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:17:46.351503Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile |
title |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile |
spellingShingle |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile Martins, Heloise Helena [UNIFESP] Liverpool Adverse Events Profile Antiepileptic drugs Epilepsy Adverse effects Symptomatic partial epilepsy Idiopathic generalized epilepsy Validation |
title_short |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile |
title_full |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile |
title_fullStr |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile |
title_full_unstemmed |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile |
title_sort |
Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile |
author |
Martins, Heloise Helena [UNIFESP] |
author_facet |
Martins, Heloise Helena [UNIFESP] Alonso, Neide Barreira [UNIFESP] Vidal-Dourado, Marcos [UNIFESP] Carbonel, Thiago Delfino [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Guilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP] |
author_role |
author |
author2 |
Alonso, Neide Barreira [UNIFESP] Vidal-Dourado, Marcos [UNIFESP] Carbonel, Thiago Delfino [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Guilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Martins, Heloise Helena [UNIFESP] Alonso, Neide Barreira [UNIFESP] Vidal-Dourado, Marcos [UNIFESP] Carbonel, Thiago Delfino [UNIFESP] Araujo Filho, Gerardo Maria de [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] Guilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP] |
dc.subject.eng.fl_str_mv |
Liverpool Adverse Events Profile Antiepileptic drugs Epilepsy Adverse effects Symptomatic partial epilepsy Idiopathic generalized epilepsy Validation |
topic |
Liverpool Adverse Events Profile Antiepileptic drugs Epilepsy Adverse effects Symptomatic partial epilepsy Idiopathic generalized epilepsy Validation |
description |
We report the results of administration of the Portuguese-Brazilian translation of the Liverpool Adverse Events Profile (LAEP) to 100 patients (mean age = 34.5, SD = 12.12; 56 females), 61 with symptomatic partial epilepsy (SPE) and 39 with idiopathic generalized epilepsy (ICE) (ILAE, 1989) who were on a stable antiepileptic drug (AED) regimen and being treated in a Brazilian tertiary epilepsy center. Carbamazepine was the most commonly used AED (43.0%), followed by valproic acid (32.0%). Two or more AEDs were used by 69.0% of patients. the mean LAEP score (19 questions) was 37.6 (SD = 13.35). the most common adverse effects were sleepiness (35.0%), memory problems (35.0%), and difficulty in concentrating (25.0%). Higher LAEP scores were associated with polytherapy with three or more AEDs (P=0.005), female gender (P<0.001), older age (P<0.001), and uncontrolled seizures (P = 0.045). the intraclass coefficient (test-retest reliability) for LAEP overall score was 0.848 (95% CI = 0.782-0.895), with a range from 0.370 (unsteadiness) to 0.750 (memory problems). Cronbach's alpha coefficient (internal consistency) was 0.903. the LAEP was highly correlated with Quality of Life in Epilepsy-31 inventory (r = -0.804, P>0.001) and Hospital Anxiety and Depression Scale (Depression: r = 0.637, P<0.001; Anxiety: r = 0.621, P<0.001) dimensions. LAEP overall scores were similar in people with SPE and IGE and were not helpful in differentiating adverse effects in these two groups. Clinical variables that influenced global LAEP were seizure frequency (P = 0.050) and generalized tonic-clonic seizures in the last month (P = 0.031) in the ICE group, and polytherapy with three or more AEDs (P = 0.003 and P = 0.003) in both ICE and SPE groups. (C) 2011 Elsevier Inc. All rights reserved. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-11-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:20Z |
dc.date.available.fl_str_mv |
2016-01-24T14:17:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 3, p. 511-517, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/34163 http://dx.doi.org/10.1016/j.yebeh.2011.08.005 |
dc.identifier.issn.none.fl_str_mv |
1525-5050 |
dc.identifier.file.none.fl_str_mv |
WOS000296826700017.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.yebeh.2011.08.005 |
dc.identifier.wos.none.fl_str_mv |
WOS:000296826700017 |
identifier_str_mv |
Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 3, p. 511-517, 2011. 1525-5050 WOS000296826700017.pdf 10.1016/j.yebeh.2011.08.005 WOS:000296826700017 |
url |
http://repositorio.unifesp.br/handle/11600/34163 http://dx.doi.org/10.1016/j.yebeh.2011.08.005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Epilepsy & Behavior |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
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openAccess |
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511-517 |
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Elsevier B.V. |
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Elsevier B.V. |
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