Influence of cyclosporine A on mucociliary system after lung transplantation in rats
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/41975 http://dx.doi.org/10.1590/S0102-86502007000600009 |
Resumo: | Purpose: To investigate the function of the bronchial mucociliary system in transplanted rat lungs with and without the influence of immunosuppression. Methods: Thirty-six rats underwent single-lung transplantation and were divided into two groups, one of which received cyclosporine treatment, and the control group which did not. Cyclosporine was administered subcutaneously in doses of 10 mg/kg daily. The rats were sacrificed 2, 15 or 30 days after transplantation. In situ bronchial mucociliary transport (MCT) and ciliary beat frequency (CBF) were determined proximal and distal to the bronchial anastomosis. Results: Significant progressive improvement on MCT, proximal and distal to the anastomotic site, was also found in the cyclosporine-treated group at 15 and 30 days (p<0.01). No significant change in MCT was found in the control group. CBF behavior in the two groups. Histological analysis showed that rejection was significantly higher in the control group (p<0.05). Conclusion: Cyclosporine has a positive influence on bronchial mucociliary transport but not on CBF due to the effect of the rejection mechanism. |
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Xavier, Alexandre Martins [UNIFESP]Pego-Fernandes, Paulo ManuelCorreia, Aristides TadeuPazetti, RogerioMonteiro, RosangelaCanzian, Mauro [UNIFESP]Jatene, Fabio BiscegliUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2018-06-15T11:14:55Z2018-06-15T11:14:55Z2007-11-01Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 22, n. 6, p. 465-469, 2007.0102-8650http://repositorio.unifesp.br/11600/41975http://dx.doi.org/10.1590/S0102-86502007000600009S0102-86502007000600009.pdfS0102-8650200700060000910.1590/S0102-86502007000600009WOS:000258573500009Purpose: To investigate the function of the bronchial mucociliary system in transplanted rat lungs with and without the influence of immunosuppression. Methods: Thirty-six rats underwent single-lung transplantation and were divided into two groups, one of which received cyclosporine treatment, and the control group which did not. Cyclosporine was administered subcutaneously in doses of 10 mg/kg daily. The rats were sacrificed 2, 15 or 30 days after transplantation. In situ bronchial mucociliary transport (MCT) and ciliary beat frequency (CBF) were determined proximal and distal to the bronchial anastomosis. Results: Significant progressive improvement on MCT, proximal and distal to the anastomotic site, was also found in the cyclosporine-treated group at 15 and 30 days (p<0.01). No significant change in MCT was found in the control group. CBF behavior in the two groups. Histological analysis showed that rejection was significantly higher in the control group (p<0.05). Conclusion: Cyclosporine has a positive influence on bronchial mucociliary transport but not on CBF due to the effect of the rejection mechanism.Univ Fed Sao Paulo, Dept Surg, Thorac Surg Div, Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Dept Cardiopneumol, Thorac Surg Div, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Lab Thorac Surg Res, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Dept Cardiopneumol, Thorac Surg Div,InCor,Clin Hosp, BR-05508 Sao Paulo, BrazilUniv Sao Paulo, Sch Med, Pathol Lab, InCor,Clin Hosp, BR-05508 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Surg, Thorac Surg Div, Sao Paulo, BrazilWeb of Science465-469engActa Cirurgica BrasileiraActa Cirurgica Brasileiralung transplantationcyclosporineimmunosuppressionmucociliary clearanceratsInfluence of cyclosporine A on mucociliary system after lung transplantation in ratsInfluência da ciclosporina A sobre o sistema mucociliar após-transplante pulmonar em ratosinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/419752021-09-30 11:04:15.013metadata only accessoai:repositorio.unifesp.br:11600/41975Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:08:14.805738Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats |
dc.title.alternative.pt.fl_str_mv |
Influência da ciclosporina A sobre o sistema mucociliar após-transplante pulmonar em ratos |
title |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats |
spellingShingle |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats Xavier, Alexandre Martins [UNIFESP] lung transplantation cyclosporine immunosuppression mucociliary clearance rats |
title_short |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats |
title_full |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats |
title_fullStr |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats |
title_full_unstemmed |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats |
title_sort |
Influence of cyclosporine A on mucociliary system after lung transplantation in rats |
author |
Xavier, Alexandre Martins [UNIFESP] |
author_facet |
Xavier, Alexandre Martins [UNIFESP] Pego-Fernandes, Paulo Manuel Correia, Aristides Tadeu Pazetti, Rogerio Monteiro, Rosangela Canzian, Mauro [UNIFESP] Jatene, Fabio Biscegli |
author_role |
author |
author2 |
Pego-Fernandes, Paulo Manuel Correia, Aristides Tadeu Pazetti, Rogerio Monteiro, Rosangela Canzian, Mauro [UNIFESP] Jatene, Fabio Biscegli |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Xavier, Alexandre Martins [UNIFESP] Pego-Fernandes, Paulo Manuel Correia, Aristides Tadeu Pazetti, Rogerio Monteiro, Rosangela Canzian, Mauro [UNIFESP] Jatene, Fabio Biscegli |
dc.subject.eng.fl_str_mv |
lung transplantation cyclosporine immunosuppression mucociliary clearance rats |
topic |
lung transplantation cyclosporine immunosuppression mucociliary clearance rats |
description |
Purpose: To investigate the function of the bronchial mucociliary system in transplanted rat lungs with and without the influence of immunosuppression. Methods: Thirty-six rats underwent single-lung transplantation and were divided into two groups, one of which received cyclosporine treatment, and the control group which did not. Cyclosporine was administered subcutaneously in doses of 10 mg/kg daily. The rats were sacrificed 2, 15 or 30 days after transplantation. In situ bronchial mucociliary transport (MCT) and ciliary beat frequency (CBF) were determined proximal and distal to the bronchial anastomosis. Results: Significant progressive improvement on MCT, proximal and distal to the anastomotic site, was also found in the cyclosporine-treated group at 15 and 30 days (p<0.01). No significant change in MCT was found in the control group. CBF behavior in the two groups. Histological analysis showed that rejection was significantly higher in the control group (p<0.05). Conclusion: Cyclosporine has a positive influence on bronchial mucociliary transport but not on CBF due to the effect of the rejection mechanism. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-11-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T11:14:55Z |
dc.date.available.fl_str_mv |
2018-06-15T11:14:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 22, n. 6, p. 465-469, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/41975 http://dx.doi.org/10.1590/S0102-86502007000600009 |
dc.identifier.issn.none.fl_str_mv |
0102-8650 |
dc.identifier.file.none.fl_str_mv |
S0102-86502007000600009.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0102-86502007000600009 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0102-86502007000600009 |
dc.identifier.wos.none.fl_str_mv |
WOS:000258573500009 |
identifier_str_mv |
Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 22, n. 6, p. 465-469, 2007. 0102-8650 S0102-86502007000600009.pdf S0102-86502007000600009 10.1590/S0102-86502007000600009 WOS:000258573500009 |
url |
http://repositorio.unifesp.br/11600/41975 http://dx.doi.org/10.1590/S0102-86502007000600009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
465-469 |
dc.publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460254291329024 |