Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35704 http://dx.doi.org/10.1155/2013/641515 |
Resumo: | The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. the studied polymorphism was analyzed by PCR/RFLP. the Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. the APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). the APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only. |
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Gregorio, Michele L.Pinhel, Marcela A. S.Sado, Caroline L. [UNIFESP]Longo, Gabriela S.Oliveira, Fabio N.Amorim, Gisele S.Nakazone, Marcelo A.Florim, Greiciane M.Mazeti, Camila M.Martins, Denise P.Tognola, Waldir A.Brandao, Antonio C.Pinheiro Junior, SidneyGodoy, Moacir F. deSouza, Doroteia R. S. [UNIFESP]Universidade de São Paulo (USP)NPBIMUniversidade Federal de São Paulo (UNIFESP)Hosp BaseSao Jose do Rio Preto Med Sch FAMERP2016-01-24T14:30:54Z2016-01-24T14:30:54Z2013-01-01Biomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2013.2314-6133http://repositorio.unifesp.br/handle/11600/35704http://dx.doi.org/10.1155/2013/641515WOS000325412500001.pdf10.1155/2013/641515WOS:000325412500001The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. the studied polymorphism was analyzed by PCR/RFLP. the Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. the APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). the APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Sao Jose do Rio Preto Medical School (FAMERP)Sao Jose do Rio Preto Med Sch FAMERP, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP, BrazilNPBIM, Ctr Res Biochem & Mol Biol, Sao Jose do Rio Preto Med Sch FAMERP, BR-15090000 Sao Jose Do Rio Preto, SP, BrazilFed Univ São Paulo UNIFESP, BR-04021001 São Paulo, BrazilHosp Base, BR-15090000 Sao Jose Do Rio Preto, SP, BrazilSao Jose do Rio Preto Med Sch FAMERP, BR-15090000 Sao Jose Do Rio Preto, SP, BrazilSao Jose do Rio Preto Med Sch FAMERP, Dept Neurosci Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP, BrazilFed Univ São Paulo UNIFESP, BR-04021001 São Paulo, BrazilFAPESP: 2009/17222-0FAPESP: 2008/53950-8FAPESP: 2009/18476-6Web of Science7engHindawi Publishing CorporationBiomed Research InternationalImpact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000325412500001.pdfapplication/pdf1214526${dspace.ui.url}/bitstream/11600/35704/1/WOS000325412500001.pdf3a74493f862151f9c32362dc33f0a474MD51open accessTEXTWOS000325412500001.pdf.txtWOS000325412500001.pdf.txtExtracted texttext/plain36155${dspace.ui.url}/bitstream/11600/35704/2/WOS000325412500001.pdf.txt47688977bc3a1110463b5066eb09068cMD52open access11600/357042022-02-18 10:09:37.752open accessoai:repositorio.unifesp.br:11600/35704Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:07:11.982870Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
title |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
spellingShingle |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease Gregorio, Michele L. |
title_short |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
title_full |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
title_fullStr |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
title_full_unstemmed |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
title_sort |
Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease |
author |
Gregorio, Michele L. |
author_facet |
Gregorio, Michele L. Pinhel, Marcela A. S. Sado, Caroline L. [UNIFESP] Longo, Gabriela S. Oliveira, Fabio N. Amorim, Gisele S. Nakazone, Marcelo A. Florim, Greiciane M. Mazeti, Camila M. Martins, Denise P. Tognola, Waldir A. Brandao, Antonio C. Pinheiro Junior, Sidney Godoy, Moacir F. de Souza, Doroteia R. S. [UNIFESP] |
author_role |
author |
author2 |
Pinhel, Marcela A. S. Sado, Caroline L. [UNIFESP] Longo, Gabriela S. Oliveira, Fabio N. Amorim, Gisele S. Nakazone, Marcelo A. Florim, Greiciane M. Mazeti, Camila M. Martins, Denise P. Tognola, Waldir A. Brandao, Antonio C. Pinheiro Junior, Sidney Godoy, Moacir F. de Souza, Doroteia R. S. [UNIFESP] |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) NPBIM Universidade Federal de São Paulo (UNIFESP) Hosp Base Sao Jose do Rio Preto Med Sch FAMERP |
dc.contributor.author.fl_str_mv |
Gregorio, Michele L. Pinhel, Marcela A. S. Sado, Caroline L. [UNIFESP] Longo, Gabriela S. Oliveira, Fabio N. Amorim, Gisele S. Nakazone, Marcelo A. Florim, Greiciane M. Mazeti, Camila M. Martins, Denise P. Tognola, Waldir A. Brandao, Antonio C. Pinheiro Junior, Sidney Godoy, Moacir F. de Souza, Doroteia R. S. [UNIFESP] |
description |
The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. the studied polymorphism was analyzed by PCR/RFLP. the Fisher's exact test, chi-square, ANOVA, and t-test (P < 0.05) were applied. the APOE3/3 genotype was prevalent in PD patients and Controls (P = 0.713) followed by APOE3/4 (P = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (P < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the APOE3/3 versus APOE-/4 genotypes (P = 0.012). the APOE polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with APOE. Furthermore, a relationship between increase of HDLc levels and APOE3 in homozygous was found in PD patients only. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:30:54Z |
dc.date.available.fl_str_mv |
2016-01-24T14:30:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35704 http://dx.doi.org/10.1155/2013/641515 |
dc.identifier.issn.none.fl_str_mv |
2314-6133 |
dc.identifier.file.none.fl_str_mv |
WOS000325412500001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1155/2013/641515 |
dc.identifier.wos.none.fl_str_mv |
WOS:000325412500001 |
identifier_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 7 p., 2013. 2314-6133 WOS000325412500001.pdf 10.1155/2013/641515 WOS:000325412500001 |
url |
http://repositorio.unifesp.br/handle/11600/35704 http://dx.doi.org/10.1155/2013/641515 |
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eng |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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