Bipolar disorder and metabolic syndrome: a systematic review
Main Author: | |
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Publication Date: | 2013 |
Other Authors: | , , |
Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UNIFESP |
Download full: | http://repositorio.unifesp.br/handle/11600/7644 http://dx.doi.org/10.1016/j.rbp.2012.00.000 |
Summary: | OBJECTIVE: Summarize data on metabolic syndrome (MS) in bipolar disorder (BD). METHODS: A systematic review of the literature was conducted using the Medline, Embase and PsycInfo databases, using the keywords metabolic syndrome, insulin resistance and metabolic X syndrome and cross-referencing them with bipolar disorder or mania. The following types of publications were candidates for review: (i) clinical trials, (ii) studies involving patients diagnosed with bipolar disorder or (iii) data about metabolic syndrome. A 5-point quality scale was used to assess the methodological weight of the studies. RESULTS: Thirty-nine articles were selected. None of studies reached the maximum quality score of 5 points. The prevalence of MS was significantly higher in BD individuals when compared to a control group. The analysis of MS subcomponents showed that abdominal obesity was heterogeneous. Individuals with BD had significantly higher rates of hypertriglyceridemia than healthy controls. When compared to the general population, there were no significant differences in the prevalence of low HDL-c in individuals with BD. Data on hypertension were also inconclusive. Rates of hyperglycemia were significantly greater in patients with BD compared to the general population. CONCLUSIONS: The overall results point to the presence of an association between BD and MS, as well as between their subcomponents. |
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Czepielewski, LetíciaDaruy Filho, LedoBrietzke, Elisa [UNIFESP]Grassi-oliveira, RodrigoPontifícia Universidade Católica do Rio Grande do Sul Developmental Cognitive Neuroscience Research GroupUniversidade Federal de São Paulo (UNIFESP)2015-06-14T13:45:18Z2015-06-14T13:45:18Z2013-03-01Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 1, p. 88-93, 2013.1516-4446http://repositorio.unifesp.br/handle/11600/7644http://dx.doi.org/10.1016/j.rbp.2012.00.000S1516-44462013000100016.pdfS1516-4446201300010001610.1016/j.rbp.2012.00.000OBJECTIVE: Summarize data on metabolic syndrome (MS) in bipolar disorder (BD). METHODS: A systematic review of the literature was conducted using the Medline, Embase and PsycInfo databases, using the keywords metabolic syndrome, insulin resistance and metabolic X syndrome and cross-referencing them with bipolar disorder or mania. The following types of publications were candidates for review: (i) clinical trials, (ii) studies involving patients diagnosed with bipolar disorder or (iii) data about metabolic syndrome. A 5-point quality scale was used to assess the methodological weight of the studies. RESULTS: Thirty-nine articles were selected. None of studies reached the maximum quality score of 5 points. The prevalence of MS was significantly higher in BD individuals when compared to a control group. The analysis of MS subcomponents showed that abdominal obesity was heterogeneous. Individuals with BD had significantly higher rates of hypertriglyceridemia than healthy controls. When compared to the general population, there were no significant differences in the prevalence of low HDL-c in individuals with BD. Data on hypertension were also inconclusive. Rates of hyperglycemia were significantly greater in patients with BD compared to the general population. CONCLUSIONS: The overall results point to the presence of an association between BD and MS, as well as between their subcomponents.Pontifícia Universidade Católica do Rio Grande do Sul Developmental Cognitive Neuroscience Research GroupUniversidade Federal de São Paulo (UNIFESP) Program for Recognition and Intervention for Individuals in At-Risk Mental StatesUniversidade Federal de São Paulo (UNIFESP) Interdisciplinary Laboratory of Clinical NeurosciencesUNIFESP, Program for Recognition and Intervention for Individuals in At-Risk Mental StatesUNIFESP, Interdisciplinary Laboratory of Clinical NeurosciencesSciELO88-93engAssociação Brasileira de Psiquiatria - ABPRevista Brasileira de PsiquiatriaBipolar DisorderCholesterolGlucoseInsulinMetabolic SyndromeMood DisordersTriglyceridesBipolar disorder and metabolic syndrome: a systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1516-44462013000100016.pdfapplication/pdf353600${dspace.ui.url}/bitstream/11600/7644/1/S1516-44462013000100016.pdfd709dd72bb5471b5396209a7cac25cdbMD51open accessTEXTS1516-44462013000100016.pdf.txtS1516-44462013000100016.pdf.txtExtracted texttext/plain31715${dspace.ui.url}/bitstream/11600/7644/2/S1516-44462013000100016.pdf.txtbfac0ed1a196e657ce51de6f3f357f1fMD52open access11600/76442021-10-05 21:43:44.128open accessoai:repositorio.unifesp.br:11600/7644Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:27:30.849925Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Bipolar disorder and metabolic syndrome: a systematic review |
title |
Bipolar disorder and metabolic syndrome: a systematic review |
spellingShingle |
Bipolar disorder and metabolic syndrome: a systematic review Czepielewski, Letícia Bipolar Disorder Cholesterol Glucose Insulin Metabolic Syndrome Mood Disorders Triglycerides |
title_short |
Bipolar disorder and metabolic syndrome: a systematic review |
title_full |
Bipolar disorder and metabolic syndrome: a systematic review |
title_fullStr |
Bipolar disorder and metabolic syndrome: a systematic review |
title_full_unstemmed |
Bipolar disorder and metabolic syndrome: a systematic review |
title_sort |
Bipolar disorder and metabolic syndrome: a systematic review |
author |
Czepielewski, Letícia |
author_facet |
Czepielewski, Letícia Daruy Filho, Ledo Brietzke, Elisa [UNIFESP] Grassi-oliveira, Rodrigo |
author_role |
author |
author2 |
Daruy Filho, Ledo Brietzke, Elisa [UNIFESP] Grassi-oliveira, Rodrigo |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Pontifícia Universidade Católica do Rio Grande do Sul Developmental Cognitive Neuroscience Research Group Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Czepielewski, Letícia Daruy Filho, Ledo Brietzke, Elisa [UNIFESP] Grassi-oliveira, Rodrigo |
dc.subject.eng.fl_str_mv |
Bipolar Disorder Cholesterol Glucose Insulin Metabolic Syndrome Mood Disorders Triglycerides |
topic |
Bipolar Disorder Cholesterol Glucose Insulin Metabolic Syndrome Mood Disorders Triglycerides |
description |
OBJECTIVE: Summarize data on metabolic syndrome (MS) in bipolar disorder (BD). METHODS: A systematic review of the literature was conducted using the Medline, Embase and PsycInfo databases, using the keywords metabolic syndrome, insulin resistance and metabolic X syndrome and cross-referencing them with bipolar disorder or mania. The following types of publications were candidates for review: (i) clinical trials, (ii) studies involving patients diagnosed with bipolar disorder or (iii) data about metabolic syndrome. A 5-point quality scale was used to assess the methodological weight of the studies. RESULTS: Thirty-nine articles were selected. None of studies reached the maximum quality score of 5 points. The prevalence of MS was significantly higher in BD individuals when compared to a control group. The analysis of MS subcomponents showed that abdominal obesity was heterogeneous. Individuals with BD had significantly higher rates of hypertriglyceridemia than healthy controls. When compared to the general population, there were no significant differences in the prevalence of low HDL-c in individuals with BD. Data on hypertension were also inconclusive. Rates of hyperglycemia were significantly greater in patients with BD compared to the general population. CONCLUSIONS: The overall results point to the presence of an association between BD and MS, as well as between their subcomponents. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-03-01 |
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2015-06-14T13:45:18Z |
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2015-06-14T13:45:18Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 1, p. 88-93, 2013. |
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http://repositorio.unifesp.br/handle/11600/7644 http://dx.doi.org/10.1016/j.rbp.2012.00.000 |
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1516-4446 |
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S1516-44462013000100016.pdf |
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S1516-44462013000100016 |
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10.1016/j.rbp.2012.00.000 |
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Revista Brasileira de Psiquiatria. Associação Brasileira de Psiquiatria - ABP, v. 35, n. 1, p. 88-93, 2013. 1516-4446 S1516-44462013000100016.pdf S1516-44462013000100016 10.1016/j.rbp.2012.00.000 |
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http://repositorio.unifesp.br/handle/11600/7644 http://dx.doi.org/10.1016/j.rbp.2012.00.000 |
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Associação Brasileira de Psiquiatria - ABP |
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Associação Brasileira de Psiquiatria - ABP |
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