Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43328 |
Resumo: | Objective Evaluate damage in oligoarticular JIA, estimating its frequency, risks and probability over time.Methods A cross-sectional and retrospective analysis of Juvenile Arthritis Damage Index (JADI) scoring, with both articular and extraarticular components, active joint count, disability index by CHAQ and Steinbrocker class, physician's global assessment, child pain and overall well-being visual analogue scale (VAS), was conducted in patients with oligoarticular JIA. Damage risk factors were estimated by univariate analysis and by generalised linear model. The probability of damage over rime was estimated by survival analysis and damage progression rates were calculated by hazard function.Results Seventy-live JIA cases were assessed, 89.3% persistent and 10.7% extended oligoarthritis, with median follow-up duration 1.7.years (IQR 1.3-3.1). Damage occurred in 38.7%. JADI-A correlated moderately only with the number of limited joints (r(s)= 0.50, p < 0.0001). Female sex (OR 3.5, 95% CI 1.0-11.6), DMARD use (OR 3.9, 95%CI 1.0-15.0) and knee involvement (OR 4.2, 95%CI 1.3-13.5) were significantly associated with joint damage, whereas only joint steroid injection was associated with extraarticular damage (OR 5.9, 95% CI 1.8-1.9.3). Damage probability at 5 years was 50% for JADI-A. and 57% for JADI-E. Calculated hazard rates each year were 16.1% and 16.3%, for JADI-A and JADI-E, respectively.Conclusion Sex DMARD use and knee involvement were associated with joint damage, whereas only joint steroid injection was associated with extraarticular damage, which progressed at stable rates over ten years. |
id |
UFSP_dae0a01255a21b88f5eb278ddc34c06e |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/43328 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Oliveira Sato, J. deCorrente, J. E.Saad-Magalhaes, C.Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2018-06-15T16:52:43Z2018-06-15T16:52:43Z2011-09-01Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 29, n. 5, p. 871-877, 2011.0392-856Xhttp://repositorio.unifesp.br/11600/43328Não UNIFESPWOS:000297192600020Objective Evaluate damage in oligoarticular JIA, estimating its frequency, risks and probability over time.Methods A cross-sectional and retrospective analysis of Juvenile Arthritis Damage Index (JADI) scoring, with both articular and extraarticular components, active joint count, disability index by CHAQ and Steinbrocker class, physician's global assessment, child pain and overall well-being visual analogue scale (VAS), was conducted in patients with oligoarticular JIA. Damage risk factors were estimated by univariate analysis and by generalised linear model. The probability of damage over rime was estimated by survival analysis and damage progression rates were calculated by hazard function.Results Seventy-live JIA cases were assessed, 89.3% persistent and 10.7% extended oligoarthritis, with median follow-up duration 1.7.years (IQR 1.3-3.1). Damage occurred in 38.7%. JADI-A correlated moderately only with the number of limited joints (r(s)= 0.50, p < 0.0001). Female sex (OR 3.5, 95% CI 1.0-11.6), DMARD use (OR 3.9, 95%CI 1.0-15.0) and knee involvement (OR 4.2, 95%CI 1.3-13.5) were significantly associated with joint damage, whereas only joint steroid injection was associated with extraarticular damage (OR 5.9, 95% CI 1.8-1.9.3). Damage probability at 5 years was 50% for JADI-A. and 57% for JADI-E. Calculated hazard rates each year were 16.1% and 16.3%, for JADI-A and JADI-E, respectively.Conclusion Sex DMARD use and knee involvement were associated with joint damage, whereas only joint steroid injection was associated with extraarticular damage, which progressed at stable rates over ten years.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Paulista, Dept Pediat, Fac Med Botucatu, Sao Paulo, BrazilUniv Estadual Paulista, Dept Bioestat, Inst Biociencias, Sao Paulo, BrazilFAPESP: 06/57993-8CNPq: CNPQ 301611/2010Web of Science871-877engClinical & Exper RheumatologyClinical And Experimental RheumatologyRemoverinfo:eu-repo/semantics/openAccessdamagedisabilityjuvenile idiopathic arthritisoligoarthritisoutcomeProgression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/433282021-10-05 22:07:13.337metadata only accessoai:repositorio.unifesp.br:11600/43328Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:15:25.772575Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis |
title |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis |
spellingShingle |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis Oliveira Sato, J. de damage disability juvenile idiopathic arthritis oligoarthritis outcome |
title_short |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis |
title_full |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis |
title_fullStr |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis |
title_full_unstemmed |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis |
title_sort |
Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis |
author |
Oliveira Sato, J. de |
author_facet |
Oliveira Sato, J. de Corrente, J. E. Saad-Magalhaes, C. |
author_role |
author |
author2 |
Corrente, J. E. Saad-Magalhaes, C. |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Oliveira Sato, J. de Corrente, J. E. Saad-Magalhaes, C. |
dc.subject.eng.fl_str_mv |
damage disability juvenile idiopathic arthritis oligoarthritis outcome |
topic |
damage disability juvenile idiopathic arthritis oligoarthritis outcome |
description |
Objective Evaluate damage in oligoarticular JIA, estimating its frequency, risks and probability over time.Methods A cross-sectional and retrospective analysis of Juvenile Arthritis Damage Index (JADI) scoring, with both articular and extraarticular components, active joint count, disability index by CHAQ and Steinbrocker class, physician's global assessment, child pain and overall well-being visual analogue scale (VAS), was conducted in patients with oligoarticular JIA. Damage risk factors were estimated by univariate analysis and by generalised linear model. The probability of damage over rime was estimated by survival analysis and damage progression rates were calculated by hazard function.Results Seventy-live JIA cases were assessed, 89.3% persistent and 10.7% extended oligoarthritis, with median follow-up duration 1.7.years (IQR 1.3-3.1). Damage occurred in 38.7%. JADI-A correlated moderately only with the number of limited joints (r(s)= 0.50, p < 0.0001). Female sex (OR 3.5, 95% CI 1.0-11.6), DMARD use (OR 3.9, 95%CI 1.0-15.0) and knee involvement (OR 4.2, 95%CI 1.3-13.5) were significantly associated with joint damage, whereas only joint steroid injection was associated with extraarticular damage (OR 5.9, 95% CI 1.8-1.9.3). Damage probability at 5 years was 50% for JADI-A. and 57% for JADI-E. Calculated hazard rates each year were 16.1% and 16.3%, for JADI-A and JADI-E, respectively.Conclusion Sex DMARD use and knee involvement were associated with joint damage, whereas only joint steroid injection was associated with extraarticular damage, which progressed at stable rates over ten years. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-09-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T16:52:43Z |
dc.date.available.fl_str_mv |
2018-06-15T16:52:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 29, n. 5, p. 871-877, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43328 Não UNIFESP |
dc.identifier.issn.none.fl_str_mv |
0392-856X |
dc.identifier.wos.none.fl_str_mv |
WOS:000297192600020 |
identifier_str_mv |
Clinical And Experimental Rheumatology. Pisa: Clinical & Exper Rheumatology, v. 29, n. 5, p. 871-877, 2011. 0392-856X Não UNIFESP WOS:000297192600020 |
url |
http://repositorio.unifesp.br/11600/43328 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Clinical And Experimental Rheumatology |
dc.rights.driver.fl_str_mv |
Remover info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Remover |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
871-877 |
dc.publisher.none.fl_str_mv |
Clinical & Exper Rheumatology |
publisher.none.fl_str_mv |
Clinical & Exper Rheumatology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460268649480192 |