Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/31396 http://dx.doi.org/10.1111/j.1469-0691.2009.02707.x |
Resumo: | The objective of this study was to evaluate Candida oral colonization in human immunodeficiency virus (HIV)-infected patients undergoing long-term highly active antiretroviral therapy (ARV). the cross-sectional study included 331 HIV patients, diagnosed from 1983 to 2003. Oral swabs were performed, and Candida species were determined using ID 32C. Isolates were tested for antifungal susceptibility. Clinical and laboratory data were collected to identify the association with Candida colonization. in total, 161 Candida isolates were detected among 147 of the 331 patients (44%), independently of the time when HIV infection was diagnosed. Candida albicans strains represented 137 (85%) of the isolates, and were susceptible to all of the tested antifungal drugs. Among the non-C. albicans strains, six isolates were dose-dependently susceptible to fluconazole, nine to itraconazole, and seven to ketoconazole. the isolation of Candida was significantly higher in patients with virological failure (83/147; p 0.0002) and CD4(+) T-lymphocyte counts < 200 cells/mm(3) (30/83; p 0.0003). Recovery of Candida in the oral cavity was independent of protease inhibitor (PI) usage (p 0.60). Colonized patients typically underwent salvage therapy (p 0.003), and had more episodes of opportunistic fungal infections (p 0.046) and malignancies (p 0.004). Oral Candida colonization in patients under ARV therapy was associated with the immunosupressed status of HIV-infected patients, i.e. low number of CD4(+) T-cells per cubic millimetre, failure of ARV therapy (salvage therapy), and higher number of opportunistic infections and malignancies. Despite the fact that PIs have in vitro antifungal activity, the use of this class of antiretroviral agent did not influence the presence of Candida in the oral cavity of AIDS patients. |
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Delgado, A. C. D.Pedro, R. de JesusAoki, F. H.Resende, M. R.Trabasso, P.Colombo, Arnaldo Lopes [UNIFESP]Oliveira, M. S. M. deMikami, Y.Moretti, M. L.Universidade Estadual de Campinas (UNICAMP)Universidade Federal de São Paulo (UNIFESP)Chiba Univ2016-01-24T13:52:22Z2016-01-24T13:52:22Z2009-04-01Clinical Microbiology and Infection. Malden: Wiley-Blackwell Publishing, Inc, v. 15, n. 4, p. 364-371, 2009.1198-743Xhttp://repositorio.unifesp.br/handle/11600/31396http://dx.doi.org/10.1111/j.1469-0691.2009.02707.xWOS000265185900011.pdf10.1111/j.1469-0691.2009.02707.xWOS:000265185900011The objective of this study was to evaluate Candida oral colonization in human immunodeficiency virus (HIV)-infected patients undergoing long-term highly active antiretroviral therapy (ARV). the cross-sectional study included 331 HIV patients, diagnosed from 1983 to 2003. Oral swabs were performed, and Candida species were determined using ID 32C. Isolates were tested for antifungal susceptibility. Clinical and laboratory data were collected to identify the association with Candida colonization. in total, 161 Candida isolates were detected among 147 of the 331 patients (44%), independently of the time when HIV infection was diagnosed. Candida albicans strains represented 137 (85%) of the isolates, and were susceptible to all of the tested antifungal drugs. Among the non-C. albicans strains, six isolates were dose-dependently susceptible to fluconazole, nine to itraconazole, and seven to ketoconazole. the isolation of Candida was significantly higher in patients with virological failure (83/147; p 0.0002) and CD4(+) T-lymphocyte counts < 200 cells/mm(3) (30/83; p 0.0003). Recovery of Candida in the oral cavity was independent of protease inhibitor (PI) usage (p 0.60). Colonized patients typically underwent salvage therapy (p 0.003), and had more episodes of opportunistic fungal infections (p 0.046) and malignancies (p 0.004). Oral Candida colonization in patients under ARV therapy was associated with the immunosupressed status of HIV-infected patients, i.e. low number of CD4(+) T-cells per cubic millimetre, failure of ARV therapy (salvage therapy), and higher number of opportunistic infections and malignancies. Despite the fact that PIs have in vitro antifungal activity, the use of this class of antiretroviral agent did not influence the presence of Candida in the oral cavity of AIDS patients.Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, Div Infect Dis, BR-13081070 Campinas, SP, BrazilUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilChiba Univ, Med Mycol Res Ctr, Chiba, JapanUniversidade Federal de São Paulo, Div Infect Dis, São Paulo, BrazilWeb of Science364-371engWiley-BlackwellClinical Microbiology and Infectionhttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlinfo:eu-repo/semantics/openAccessAntiretroviral therapyCandida oral colonizationHIV patientClinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonizationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000265185900011.pdfapplication/pdf188929${dspace.ui.url}/bitstream/11600/31396/1/WOS000265185900011.pdf9970e9c8360b735e108ea66f68d4f8a2MD51open accessTEXTWOS000265185900011.pdf.txtWOS000265185900011.pdf.txtExtracted texttext/plain39229${dspace.ui.url}/bitstream/11600/31396/2/WOS000265185900011.pdf.txt79a3c22cfe38828c56f72b5fad2db5a6MD52open access11600/313962023-01-12 22:12:02.408open accessoai:repositorio.unifesp.br:11600/31396Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:12:16.464589Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization |
title |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization |
spellingShingle |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization Delgado, A. C. D. Antiretroviral therapy Candida oral colonization HIV patient |
title_short |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization |
title_full |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization |
title_fullStr |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization |
title_full_unstemmed |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization |
title_sort |
Clinical and microbiological assessment of patients with a long-term diagnosis of human immunodeficiency virus infection and Candida oral colonization |
author |
Delgado, A. C. D. |
author_facet |
Delgado, A. C. D. Pedro, R. de Jesus Aoki, F. H. Resende, M. R. Trabasso, P. Colombo, Arnaldo Lopes [UNIFESP] Oliveira, M. S. M. de Mikami, Y. Moretti, M. L. |
author_role |
author |
author2 |
Pedro, R. de Jesus Aoki, F. H. Resende, M. R. Trabasso, P. Colombo, Arnaldo Lopes [UNIFESP] Oliveira, M. S. M. de Mikami, Y. Moretti, M. L. |
author2_role |
author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Federal de São Paulo (UNIFESP) Chiba Univ |
dc.contributor.author.fl_str_mv |
Delgado, A. C. D. Pedro, R. de Jesus Aoki, F. H. Resende, M. R. Trabasso, P. Colombo, Arnaldo Lopes [UNIFESP] Oliveira, M. S. M. de Mikami, Y. Moretti, M. L. |
dc.subject.eng.fl_str_mv |
Antiretroviral therapy Candida oral colonization HIV patient |
topic |
Antiretroviral therapy Candida oral colonization HIV patient |
description |
The objective of this study was to evaluate Candida oral colonization in human immunodeficiency virus (HIV)-infected patients undergoing long-term highly active antiretroviral therapy (ARV). the cross-sectional study included 331 HIV patients, diagnosed from 1983 to 2003. Oral swabs were performed, and Candida species were determined using ID 32C. Isolates were tested for antifungal susceptibility. Clinical and laboratory data were collected to identify the association with Candida colonization. in total, 161 Candida isolates were detected among 147 of the 331 patients (44%), independently of the time when HIV infection was diagnosed. Candida albicans strains represented 137 (85%) of the isolates, and were susceptible to all of the tested antifungal drugs. Among the non-C. albicans strains, six isolates were dose-dependently susceptible to fluconazole, nine to itraconazole, and seven to ketoconazole. the isolation of Candida was significantly higher in patients with virological failure (83/147; p 0.0002) and CD4(+) T-lymphocyte counts < 200 cells/mm(3) (30/83; p 0.0003). Recovery of Candida in the oral cavity was independent of protease inhibitor (PI) usage (p 0.60). Colonized patients typically underwent salvage therapy (p 0.003), and had more episodes of opportunistic fungal infections (p 0.046) and malignancies (p 0.004). Oral Candida colonization in patients under ARV therapy was associated with the immunosupressed status of HIV-infected patients, i.e. low number of CD4(+) T-cells per cubic millimetre, failure of ARV therapy (salvage therapy), and higher number of opportunistic infections and malignancies. Despite the fact that PIs have in vitro antifungal activity, the use of this class of antiretroviral agent did not influence the presence of Candida in the oral cavity of AIDS patients. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-04-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:52:22Z |
dc.date.available.fl_str_mv |
2016-01-24T13:52:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinical Microbiology and Infection. Malden: Wiley-Blackwell Publishing, Inc, v. 15, n. 4, p. 364-371, 2009. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/31396 http://dx.doi.org/10.1111/j.1469-0691.2009.02707.x |
dc.identifier.issn.none.fl_str_mv |
1198-743X |
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WOS000265185900011.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1469-0691.2009.02707.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000265185900011 |
identifier_str_mv |
Clinical Microbiology and Infection. Malden: Wiley-Blackwell Publishing, Inc, v. 15, n. 4, p. 364-371, 2009. 1198-743X WOS000265185900011.pdf 10.1111/j.1469-0691.2009.02707.x WOS:000265185900011 |
url |
http://repositorio.unifesp.br/handle/11600/31396 http://dx.doi.org/10.1111/j.1469-0691.2009.02707.x |
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eng |
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Clinical Microbiology and Infection |
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Wiley-Blackwell |
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