Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/35277 https://dx.doi.org/10.1186/1475-2891-11-74 |
Resumo: | Aim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways. |
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Lira, Fabio Santos de [UNIFESP]Rosa Neto, José Cesar [UNIFESP]Pimentel, Gustavo Duarte [UNIFESP]Santos, Ronaldo Vagner Thomatieli dos [UNIFESP]Carnier, June [UNIFESP]Sanches, Priscila de Lima [UNIFESP]Piano, Aline de [UNIFESP]Souza, Claudio T. deTock, Lian [UNIFESP]Tufik, Sergio [UNIFESP]Mello, Marco Tulio de [UNIFESP]Seelaender, Marilia Cerqueira Leite [UNIFESP]Nascimento, Claudia Maria da Penha Oller do [UNIFESP]Oyama, Lila Missae [UNIFESP]Dâmaso, Ana Raimunda [UNIFESP]Dept FisiolDept BiocienciasDept PsicobiolUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Univ So Santa Catarina2016-01-24T14:27:42Z2016-01-24T14:27:42Z2012-09-18Nutrition Journal. London: Biomed Central Ltd, v. 11, 7 p., 2012.1475-2891https://repositorio.unifesp.br/handle/11600/35277https://dx.doi.org/10.1186/1475-2891-11-74WOS000310462200001.pdf10.1186/1475-2891-11-74WOS:000310462200001Aim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Dept Fisiol, São Paulo, BrazilDept Biociencias, São Paulo, BrazilDept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilICB Univ São Paulo USP, Grp Metab & Canc, São Paulo, BrazilUniv So Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, Criciuma, SC, BrazilUniversidade Federal de São Paulo UNIFESP, São Paulo, BrazilFAPESP: 2011/50356-0FAPESP: 2011/50414-0Web of Science7engBiomed Central LtdNutrition JournalObesityCytokinesEndotoxinInsulin resistanceInterdisciplinary therapyLong-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescentsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000310462200001.pdfapplication/pdf374080${dspace.ui.url}/bitstream/11600/35277/1/WOS000310462200001.pdffe9e5a61b22f5dc115425ca9988efb1dMD51open accessTEXTWOS000310462200001.pdf.txtWOS000310462200001.pdf.txtExtracted texttext/plain36016${dspace.ui.url}/bitstream/11600/35277/2/WOS000310462200001.pdf.txtf6bd234ffcaf97f6b6f6aef143b00d37MD52open access11600/352772021-09-30 17:26:56.433open accessoai:repositorio.unifesp.br:11600/35277Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:19:36.322399Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
title |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
spellingShingle |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents Lira, Fabio Santos de [UNIFESP] Obesity Cytokines Endotoxin Insulin resistance Interdisciplinary therapy |
title_short |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
title_full |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
title_fullStr |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
title_full_unstemmed |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
title_sort |
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents |
author |
Lira, Fabio Santos de [UNIFESP] |
author_facet |
Lira, Fabio Santos de [UNIFESP] Rosa Neto, José Cesar [UNIFESP] Pimentel, Gustavo Duarte [UNIFESP] Santos, Ronaldo Vagner Thomatieli dos [UNIFESP] Carnier, June [UNIFESP] Sanches, Priscila de Lima [UNIFESP] Piano, Aline de [UNIFESP] Souza, Claudio T. de Tock, Lian [UNIFESP] Tufik, Sergio [UNIFESP] Mello, Marco Tulio de [UNIFESP] Seelaender, Marilia Cerqueira Leite [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Oyama, Lila Missae [UNIFESP] Dâmaso, Ana Raimunda [UNIFESP] |
author_role |
author |
author2 |
Rosa Neto, José Cesar [UNIFESP] Pimentel, Gustavo Duarte [UNIFESP] Santos, Ronaldo Vagner Thomatieli dos [UNIFESP] Carnier, June [UNIFESP] Sanches, Priscila de Lima [UNIFESP] Piano, Aline de [UNIFESP] Souza, Claudio T. de Tock, Lian [UNIFESP] Tufik, Sergio [UNIFESP] Mello, Marco Tulio de [UNIFESP] Seelaender, Marilia Cerqueira Leite [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Oyama, Lila Missae [UNIFESP] Dâmaso, Ana Raimunda [UNIFESP] |
author2_role |
author author author author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Dept Fisiol Dept Biociencias Dept Psicobiol Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) Univ So Santa Catarina |
dc.contributor.author.fl_str_mv |
Lira, Fabio Santos de [UNIFESP] Rosa Neto, José Cesar [UNIFESP] Pimentel, Gustavo Duarte [UNIFESP] Santos, Ronaldo Vagner Thomatieli dos [UNIFESP] Carnier, June [UNIFESP] Sanches, Priscila de Lima [UNIFESP] Piano, Aline de [UNIFESP] Souza, Claudio T. de Tock, Lian [UNIFESP] Tufik, Sergio [UNIFESP] Mello, Marco Tulio de [UNIFESP] Seelaender, Marilia Cerqueira Leite [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Oyama, Lila Missae [UNIFESP] Dâmaso, Ana Raimunda [UNIFESP] |
dc.subject.eng.fl_str_mv |
Obesity Cytokines Endotoxin Insulin resistance Interdisciplinary therapy |
topic |
Obesity Cytokines Endotoxin Insulin resistance Interdisciplinary therapy |
description |
Aim: the purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy.Design: the present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. in addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR).Results: the most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. in addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels.Conclusions: the present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. in addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-09-18 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:27:42Z |
dc.date.available.fl_str_mv |
2016-01-24T14:27:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Nutrition Journal. London: Biomed Central Ltd, v. 11, 7 p., 2012. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/35277 https://dx.doi.org/10.1186/1475-2891-11-74 |
dc.identifier.issn.none.fl_str_mv |
1475-2891 |
dc.identifier.file.none.fl_str_mv |
WOS000310462200001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1186/1475-2891-11-74 |
dc.identifier.wos.none.fl_str_mv |
WOS:000310462200001 |
identifier_str_mv |
Nutrition Journal. London: Biomed Central Ltd, v. 11, 7 p., 2012. 1475-2891 WOS000310462200001.pdf 10.1186/1475-2891-11-74 WOS:000310462200001 |
url |
https://repositorio.unifesp.br/handle/11600/35277 https://dx.doi.org/10.1186/1475-2891-11-74 |
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eng |
language |
eng |
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Nutrition Journal |
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openAccess |
dc.format.none.fl_str_mv |
7 |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
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