Bone mineral density in juvenile systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/1529 http://dx.doi.org/10.1590/S0100-879X2002001000008 |
Resumo: | We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All parameters were used as potential determinant factors for bone loss. Lumbar BMD tended to be lower in the JSLE patients, however, this difference was not statistically significant (P = 0.10). No significant correlation was observed in JSLE girls between BMD and age, height, Tanner stage, disease duration, corticosteroid use or disease activity. We found a weak correlation between BMD and weight (r = 0.672). In the JSLE group we found no significant parameters to correlate with reduced bone mass. Disease activity and mean cumulative steroid doses were not related to BMD values. We did not observe reduced bone mass in female JSLE. |
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Castro, Tania Caroline Monteiro de [UNIFESP]Terreri, Maria Teresa Ramos Ascensão [UNIFESP]Szejnfeld, Vera Lucia [UNIFESP]Castro, Charlles Heldan de Moura [UNIFESP]Fisberg, Mauro [UNIFESP]Gabay, M. [UNIFESP]Hilário, Maria Odete Esteves [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:29:48Z2015-06-14T13:29:48Z2002-10-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1159-1163, 2002.0100-879Xhttp://repositorio.unifesp.br/handle/11600/1529http://dx.doi.org/10.1590/S0100-879X2002001000008S0100-879X2002001000008.pdfS0100-879X200200100000810.1590/S0100-879X2002001000008WOS:000179717000008We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All parameters were used as potential determinant factors for bone loss. Lumbar BMD tended to be lower in the JSLE patients, however, this difference was not statistically significant (P = 0.10). No significant correlation was observed in JSLE girls between BMD and age, height, Tanner stage, disease duration, corticosteroid use or disease activity. We found a weak correlation between BMD and weight (r = 0.672). In the JSLE group we found no significant parameters to correlate with reduced bone mass. Disease activity and mean cumulative steroid doses were not related to BMD values. We did not observe reduced bone mass in female JSLE.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PediatriaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de MedicinaUNIFESP, EPM, Depto. de PediatriaUNIFESP, EPM, Depto. de MedicinaSciELO1159-1163engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchSystemic lupus erythematosusChildrenAdolescentsBone mineral densityOsteoporosisCorticosteroidsBone mineral density in juvenile systemic lupus erythematosusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2002001000008.pdfapplication/pdf466068${dspace.ui.url}/bitstream/11600/1529/1/S0100-879X2002001000008.pdfe02335097ab35df1980105f60859e7efMD51open accessTEXTS0100-879X2002001000008.pdf.txtS0100-879X2002001000008.pdf.txtExtracted texttext/plain19259${dspace.ui.url}/bitstream/11600/1529/21/S0100-879X2002001000008.pdf.txt4eaf848374d98e470d4d76500fc497beMD521open accessTHUMBNAILS0100-879X2002001000008.pdf.jpgS0100-879X2002001000008.pdf.jpgIM Thumbnailimage/jpeg5471${dspace.ui.url}/bitstream/11600/1529/23/S0100-879X2002001000008.pdf.jpgd2ec2611430c575274f9451b74618033MD523open access11600/15292023-06-05 19:07:22.182open accessoai:repositorio.unifesp.br:11600/1529Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:07:22Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Bone mineral density in juvenile systemic lupus erythematosus |
title |
Bone mineral density in juvenile systemic lupus erythematosus |
spellingShingle |
Bone mineral density in juvenile systemic lupus erythematosus Castro, Tania Caroline Monteiro de [UNIFESP] Systemic lupus erythematosus Children Adolescents Bone mineral density Osteoporosis Corticosteroids |
title_short |
Bone mineral density in juvenile systemic lupus erythematosus |
title_full |
Bone mineral density in juvenile systemic lupus erythematosus |
title_fullStr |
Bone mineral density in juvenile systemic lupus erythematosus |
title_full_unstemmed |
Bone mineral density in juvenile systemic lupus erythematosus |
title_sort |
Bone mineral density in juvenile systemic lupus erythematosus |
author |
Castro, Tania Caroline Monteiro de [UNIFESP] |
author_facet |
Castro, Tania Caroline Monteiro de [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Szejnfeld, Vera Lucia [UNIFESP] Castro, Charlles Heldan de Moura [UNIFESP] Fisberg, Mauro [UNIFESP] Gabay, M. [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] |
author_role |
author |
author2 |
Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Szejnfeld, Vera Lucia [UNIFESP] Castro, Charlles Heldan de Moura [UNIFESP] Fisberg, Mauro [UNIFESP] Gabay, M. [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Castro, Tania Caroline Monteiro de [UNIFESP] Terreri, Maria Teresa Ramos Ascensão [UNIFESP] Szejnfeld, Vera Lucia [UNIFESP] Castro, Charlles Heldan de Moura [UNIFESP] Fisberg, Mauro [UNIFESP] Gabay, M. [UNIFESP] Hilário, Maria Odete Esteves [UNIFESP] |
dc.subject.eng.fl_str_mv |
Systemic lupus erythematosus Children Adolescents Bone mineral density Osteoporosis Corticosteroids |
topic |
Systemic lupus erythematosus Children Adolescents Bone mineral density Osteoporosis Corticosteroids |
description |
We evaluated spine bone mineral density (BMD) in Brazilian children with juvenile systemic lupus erythematosus (JSLE) in order to detect potential predictors of reduction in bone mass. A cross-sectional study of BMD at the lumbar spine level (L2-L4) was conducted on 16 female JSLE patients aged 6-17 years. Thirty-two age-matched healthy girls were used as control. BMD at the lumbar spine was measured by dual-energy X-ray absorptiometry. Weight, height and pubertal Tanner stage were determined in patients and controls. Disease duration, mean daily steroid doses, mean cumulative steroid doses and JSLE activity measured by the systemic lupus erythematosus disease activity index (SLEDAI) were determined for all JSLE patients based on their medical charts. All parameters were used as potential determinant factors for bone loss. Lumbar BMD tended to be lower in the JSLE patients, however, this difference was not statistically significant (P = 0.10). No significant correlation was observed in JSLE girls between BMD and age, height, Tanner stage, disease duration, corticosteroid use or disease activity. We found a weak correlation between BMD and weight (r = 0.672). In the JSLE group we found no significant parameters to correlate with reduced bone mass. Disease activity and mean cumulative steroid doses were not related to BMD values. We did not observe reduced bone mass in female JSLE. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002-10-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:29:48Z |
dc.date.available.fl_str_mv |
2015-06-14T13:29:48Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1159-1163, 2002. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/1529 http://dx.doi.org/10.1590/S0100-879X2002001000008 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2002001000008.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2002001000008 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2002001000008 |
dc.identifier.wos.none.fl_str_mv |
WOS:000179717000008 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 35, n. 10, p. 1159-1163, 2002. 0100-879X S0100-879X2002001000008.pdf S0100-879X2002001000008 10.1590/S0100-879X2002001000008 WOS:000179717000008 |
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http://repositorio.unifesp.br/handle/11600/1529 http://dx.doi.org/10.1590/S0100-879X2002001000008 |
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eng |
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Brazilian Journal of Medical and Biological Research |
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openAccess |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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