Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice

Detalhes bibliográficos
Autor(a) principal: Moura Estevao, Ligia Reis
Data de Publicação: 2017
Outros Autores: Simoes, Ricardo Santos [UNIFESP], Cassini-Vieira, Puebla, Campos Canesso, Maria Cecilia, Barcelos, Luciola da Silva, Rachid, Milene Alvarenga, Gomes da Cmara, Claudio Augusto, Evencio-Neto, Joaquim
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/51254
http://dx.doi.org/10.1590/s0102-865020170090000005
Resumo: Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate
id UFSP_ee115ea96d18aae42aa998d0bb08833a
oai_identifier_str oai:repositorio.unifesp.br:11600/51254
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Moura Estevao, Ligia ReisSimoes, Ricardo Santos [UNIFESP]Cassini-Vieira, PueblaCampos Canesso, Maria CeciliaBarcelos, Luciola da SilvaRachid, Milene AlvarengaGomes da Cmara, Claudio AugustoEvencio-Neto, Joaquim2019-08-19T11:48:27Z2019-08-19T11:48:27Z2017Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 9, p. 726-735, 2017.0102-8650http://repositorio.unifesp.br/handle/11600/51254http://dx.doi.org/10.1590/s0102-865020170090000005WOS000412738500005.pdfS0102-8650201700090072610.1590/s0102-865020170090000005WOS:000412738500005Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure ratethe inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-beta-D-glucosaminidase activities. The levels of TNF-alpha, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results: We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco (FACEPE)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Rural Pernambuco UFRPE, Dept Morphol & Anim Physiol, Recife, PE, BrazilUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, BrazilUniv Fed Rural Pernambuco, Dept Chem, Recife, PE, BrazilUniv Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Recife, PE, BrazilUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, BrazilWeb of Science726-735engActa Cirurgica BrasileiraWound HealingAngiogenesis Modulating AgentsAnti-Inflammatory AgentsPhytotherapySkinMiceSchinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000412738500005.pdfapplication/pdf1395072${dspace.ui.url}/bitstream/11600/51254/1/WOS000412738500005.pdf3d074ab1a4bd533a9b6ac2818055242bMD51open accessTEXTWOS000412738500005.pdf.txtWOS000412738500005.pdf.txtExtracted texttext/plain29326${dspace.ui.url}/bitstream/11600/51254/2/WOS000412738500005.pdf.txta7e48d5d66001160d9b7832ffcbd2ce0MD52open accessTHUMBNAILWOS000412738500005.pdf.jpgWOS000412738500005.pdf.jpgIM Thumbnailimage/jpeg7864${dspace.ui.url}/bitstream/11600/51254/4/WOS000412738500005.pdf.jpg1a1ffa876a66360abd7ecd92f8d40a9bMD54open access11600/512542022-08-01 18:50:15.65open accessoai:repositorio.unifesp.br:11600/51254Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:20:38.954967Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
title Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
spellingShingle Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
Moura Estevao, Ligia Reis
Wound Healing
Angiogenesis Modulating Agents
Anti-Inflammatory Agents
Phytotherapy
Skin
Mice
title_short Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
title_full Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
title_fullStr Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
title_full_unstemmed Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
title_sort Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
author Moura Estevao, Ligia Reis
author_facet Moura Estevao, Ligia Reis
Simoes, Ricardo Santos [UNIFESP]
Cassini-Vieira, Puebla
Campos Canesso, Maria Cecilia
Barcelos, Luciola da Silva
Rachid, Milene Alvarenga
Gomes da Cmara, Claudio Augusto
Evencio-Neto, Joaquim
author_role author
author2 Simoes, Ricardo Santos [UNIFESP]
Cassini-Vieira, Puebla
Campos Canesso, Maria Cecilia
Barcelos, Luciola da Silva
Rachid, Milene Alvarenga
Gomes da Cmara, Claudio Augusto
Evencio-Neto, Joaquim
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura Estevao, Ligia Reis
Simoes, Ricardo Santos [UNIFESP]
Cassini-Vieira, Puebla
Campos Canesso, Maria Cecilia
Barcelos, Luciola da Silva
Rachid, Milene Alvarenga
Gomes da Cmara, Claudio Augusto
Evencio-Neto, Joaquim
dc.subject.eng.fl_str_mv Wound Healing
Angiogenesis Modulating Agents
Anti-Inflammatory Agents
Phytotherapy
Skin
Mice
topic Wound Healing
Angiogenesis Modulating Agents
Anti-Inflammatory Agents
Phytotherapy
Skin
Mice
description Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2019-08-19T11:48:27Z
dc.date.available.fl_str_mv 2019-08-19T11:48:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 9, p. 726-735, 2017.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/51254
http://dx.doi.org/10.1590/s0102-865020170090000005
dc.identifier.issn.none.fl_str_mv 0102-8650
dc.identifier.file.none.fl_str_mv WOS000412738500005.pdf
dc.identifier.scielo.none.fl_str_mv S0102-86502017000900726
dc.identifier.doi.none.fl_str_mv 10.1590/s0102-865020170090000005
dc.identifier.wos.none.fl_str_mv WOS:000412738500005
identifier_str_mv Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 9, p. 726-735, 2017.
0102-8650
WOS000412738500005.pdf
S0102-86502017000900726
10.1590/s0102-865020170090000005
WOS:000412738500005
url http://repositorio.unifesp.br/handle/11600/51254
http://dx.doi.org/10.1590/s0102-865020170090000005
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 726-735
dc.publisher.none.fl_str_mv Acta Cirurgica Brasileira
publisher.none.fl_str_mv Acta Cirurgica Brasileira
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
bitstream.url.fl_str_mv ${dspace.ui.url}/bitstream/11600/51254/1/WOS000412738500005.pdf
${dspace.ui.url}/bitstream/11600/51254/2/WOS000412738500005.pdf.txt
${dspace.ui.url}/bitstream/11600/51254/4/WOS000412738500005.pdf.jpg
bitstream.checksum.fl_str_mv 3d074ab1a4bd533a9b6ac2818055242b
a7e48d5d66001160d9b7832ffcbd2ce0
1a1ffa876a66360abd7ecd92f8d40a9b
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1783460278904553472

Registros relacionados