More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36448 http://dx.doi.org/10.1016/j.pnpbp.2013.01.009 |
Resumo: | Although the influence of sex on sleep pattern and cardiovascular parameters is well known, knowledge regarding the effects of sleep loss on heart responses in both sexes is scarce. the present study investigated the effects of paradoxical sleep deprivation (PSD) and chronic sleep restriction (SR) on cardiovascular parameters and adrenocorticotropic hormone (ACTH) levels in male and female rats. Both groups were randomly assigned to PSD for 96 h, SR for 21 days or home-cage control. Mean arterial pressure (MAP), heart rate (HR), baroreflex sensitivity (bradycardia and tachycardia responses) and ACTH levels were evaluated. the results showed that PSD induced a significant increase in HR and ACTH levels in both sexes, although male rats presented higher levels of ACTH hormone compared to females. in addition to sex-specific responses, PSD decreased the tachycardia only in male rats. SR, induced a significant increase in MAP and decrease in bradycardia in both sexes. Male rats were more affected by sleep deprivation protocols than females for MAP, bradycardia response, and ACTH levels. the results showed that the effects of sleep loss on cardiovascular parameters are associated with the protocol of sleep deprivation and that sex can modulate these effects. We suggested this experimental model as a suitable tool for further investigations of the relationship between cardiovascular parameters and sleep. (C) 2013 Elsevier Inc. All rights reserved. |
id |
UFSP_f01df2603943bbe483bc71f087bdd6e1 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/36448 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Matos, Gabriela de [UNIFESP]Tenorio, Neuli Maria [UNIFESP]Bergamaschi, Cassia Toledo [UNIFESP]Campos, Ruy Ribeiro [UNIFESP]Cintra, Fátima Dumas [UNIFESP]Tufik, Sergio [UNIFESP]Andersen, Monica Levy [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:31:54Z2016-01-24T14:31:54Z2013-07-01Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 44, p. 34-38, 2013.0278-5846http://repositorio.unifesp.br/handle/11600/36448http://dx.doi.org/10.1016/j.pnpbp.2013.01.009WOS000320297400005.pdf10.1016/j.pnpbp.2013.01.009WOS:000320297400005Although the influence of sex on sleep pattern and cardiovascular parameters is well known, knowledge regarding the effects of sleep loss on heart responses in both sexes is scarce. the present study investigated the effects of paradoxical sleep deprivation (PSD) and chronic sleep restriction (SR) on cardiovascular parameters and adrenocorticotropic hormone (ACTH) levels in male and female rats. Both groups were randomly assigned to PSD for 96 h, SR for 21 days or home-cage control. Mean arterial pressure (MAP), heart rate (HR), baroreflex sensitivity (bradycardia and tachycardia responses) and ACTH levels were evaluated. the results showed that PSD induced a significant increase in HR and ACTH levels in both sexes, although male rats presented higher levels of ACTH hormone compared to females. in addition to sex-specific responses, PSD decreased the tachycardia only in male rats. SR, induced a significant increase in MAP and decrease in bradycardia in both sexes. Male rats were more affected by sleep deprivation protocols than females for MAP, bradycardia response, and ACTH levels. the results showed that the effects of sleep loss on cardiovascular parameters are associated with the protocol of sleep deprivation and that sex can modulate these effects. We suggested this experimental model as a suitable tool for further investigations of the relationship between cardiovascular parameters and sleep. (C) 2013 Elsevier Inc. All rights reserved.Associacao Fundo de Incentivo a PesquisaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, BrazilFAPESP: 10/15110-8FAPESP: 12/05396-7Web of Science34-38engElsevier B.V.Progress in Neuro-psychopharmacology & Biological Psychiatryhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessACTHCardiovascularRatsSexSleep deprivationMore than hormones: Sex differences in cardiovascular parameters after sleep loss in ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000320297400005.pdfapplication/pdf381259${dspace.ui.url}/bitstream/11600/36448/1/WOS000320297400005.pdf91b2a8ae5cf0b8677e576cb695ea93e4MD51open accessTEXTWOS000320297400005.pdf.txtWOS000320297400005.pdf.txtExtracted texttext/plain32636${dspace.ui.url}/bitstream/11600/36448/2/WOS000320297400005.pdf.txta6a9474bf609b0b56a43b53a5c3c58feMD52open access11600/364482022-07-08 10:51:16.607open accessoai:repositorio.unifesp.br:11600/36448Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:20:57.203233Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats |
title |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats |
spellingShingle |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats Matos, Gabriela de [UNIFESP] ACTH Cardiovascular Rats Sex Sleep deprivation |
title_short |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats |
title_full |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats |
title_fullStr |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats |
title_full_unstemmed |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats |
title_sort |
More than hormones: Sex differences in cardiovascular parameters after sleep loss in rats |
author |
Matos, Gabriela de [UNIFESP] |
author_facet |
Matos, Gabriela de [UNIFESP] Tenorio, Neuli Maria [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Cintra, Fátima Dumas [UNIFESP] Tufik, Sergio [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author_role |
author |
author2 |
Tenorio, Neuli Maria [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Cintra, Fátima Dumas [UNIFESP] Tufik, Sergio [UNIFESP] Andersen, Monica Levy [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Matos, Gabriela de [UNIFESP] Tenorio, Neuli Maria [UNIFESP] Bergamaschi, Cassia Toledo [UNIFESP] Campos, Ruy Ribeiro [UNIFESP] Cintra, Fátima Dumas [UNIFESP] Tufik, Sergio [UNIFESP] Andersen, Monica Levy [UNIFESP] |
dc.subject.eng.fl_str_mv |
ACTH Cardiovascular Rats Sex Sleep deprivation |
topic |
ACTH Cardiovascular Rats Sex Sleep deprivation |
description |
Although the influence of sex on sleep pattern and cardiovascular parameters is well known, knowledge regarding the effects of sleep loss on heart responses in both sexes is scarce. the present study investigated the effects of paradoxical sleep deprivation (PSD) and chronic sleep restriction (SR) on cardiovascular parameters and adrenocorticotropic hormone (ACTH) levels in male and female rats. Both groups were randomly assigned to PSD for 96 h, SR for 21 days or home-cage control. Mean arterial pressure (MAP), heart rate (HR), baroreflex sensitivity (bradycardia and tachycardia responses) and ACTH levels were evaluated. the results showed that PSD induced a significant increase in HR and ACTH levels in both sexes, although male rats presented higher levels of ACTH hormone compared to females. in addition to sex-specific responses, PSD decreased the tachycardia only in male rats. SR, induced a significant increase in MAP and decrease in bradycardia in both sexes. Male rats were more affected by sleep deprivation protocols than females for MAP, bradycardia response, and ACTH levels. the results showed that the effects of sleep loss on cardiovascular parameters are associated with the protocol of sleep deprivation and that sex can modulate these effects. We suggested this experimental model as a suitable tool for further investigations of the relationship between cardiovascular parameters and sleep. (C) 2013 Elsevier Inc. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-07-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:54Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 44, p. 34-38, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36448 http://dx.doi.org/10.1016/j.pnpbp.2013.01.009 |
dc.identifier.issn.none.fl_str_mv |
0278-5846 |
dc.identifier.file.none.fl_str_mv |
WOS000320297400005.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.pnpbp.2013.01.009 |
dc.identifier.wos.none.fl_str_mv |
WOS:000320297400005 |
identifier_str_mv |
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 44, p. 34-38, 2013. 0278-5846 WOS000320297400005.pdf 10.1016/j.pnpbp.2013.01.009 WOS:000320297400005 |
url |
http://repositorio.unifesp.br/handle/11600/36448 http://dx.doi.org/10.1016/j.pnpbp.2013.01.009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Progress in Neuro-psychopharmacology & Biological Psychiatry |
dc.rights.driver.fl_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
34-38 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/36448/1/WOS000320297400005.pdf ${dspace.ui.url}/bitstream/11600/36448/2/WOS000320297400005.pdf.txt |
bitstream.checksum.fl_str_mv |
91b2a8ae5cf0b8677e576cb695ea93e4 a6a9474bf609b0b56a43b53a5c3c58fe |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460279660576768 |