Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

• Autor(a) principal: Ueta, Mayumi
• Data de Publicação: 2014
• Outros Autores: Kannabiran, Chitra, Wakamatsu, Tais Hitomi [UNIFESP], Kim, Mee Kum, Yoon, Kyung-Chul, Seo, Kyoung Yul, Joo, Choun-Ki, Sangwan, Virender, Rathi, Varsha, Basu, Sayan, Shamaila, Almas, Lee, Hyo Seok, Yoon, Sangchul, Sotozono, Chie, Gomes, José Álvaro Pereira [UNIFESP], Tokunaga, Katsushi, Kinoshita, Shigeru
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/38081; http://dx.doi.org/10.1038/srep05981

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. in this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean-but not the Indian and Brazilian population.