The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/56449 http://dx.doi.org/10.1111/epi.13604 |
Resumo: | Since previous reviews of epidemiologic studies of premature mortality among people with epilepsy were completed several years ago, a large body of new evidence about this subject has been published. We aim to update prior reviews of mortality in epilepsy and to reevaluate and quantify the risks, potential risk factors, and causes of these deaths. We systematically searched the Medline and Embase databases to identify published reports describing mortality risks in cohorts and populations of people with epilepsy. We reviewed relevant reports and applied criteria to identify those studies likely to accurately quantify these risks in representative populations. From these we extracted and summarized the reported data. All population-based studies reported an increased risk of premature mortality among people with epilepsy compared to general populations. Standard mortality ratios are especially high among people with epilepsy aged <50 years, among those whose epilepsy is categorized as structural/metabolic, those whose seizures do not fully remit under treatment, and those with convulsive seizures. Among deaths directly attributable to epilepsy or seizures, important immediate causes include sudden unexpected death in epilepsy (SUDEP), status epilepticus, unintentional injuries, and suicide. Epilepsy-associated premature mortality imposes a significant public health burden, and many of the specific causes of death are potentially preventable. These require increased attention from healthcare providers, researchers, and public health professionals. |
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Thurman, David J.Logroscino, GiancarloBeghi, EttoreHauser, W. AllenHesdorffer, Dale C.Newton, Charles R.Scorza, Fulvio Alexandre [UNIFESP]Sander, Josemir W.Tomson, Torbjorn2020-07-31T12:46:54Z2020-07-31T12:46:54Z2017Epilepsia. Hoboken, v. 58, n. 1, p. 17-26, 2017.0013-9580https://repositorio.unifesp.br/handle/11600/56449http://dx.doi.org/10.1111/epi.1360410.1111/epi.13604WOS:000393682700005Since previous reviews of epidemiologic studies of premature mortality among people with epilepsy were completed several years ago, a large body of new evidence about this subject has been published. We aim to update prior reviews of mortality in epilepsy and to reevaluate and quantify the risks, potential risk factors, and causes of these deaths. We systematically searched the Medline and Embase databases to identify published reports describing mortality risks in cohorts and populations of people with epilepsy. We reviewed relevant reports and applied criteria to identify those studies likely to accurately quantify these risks in representative populations. From these we extracted and summarized the reported data. All population-based studies reported an increased risk of premature mortality among people with epilepsy compared to general populations. Standard mortality ratios are especially high among people with epilepsy aged <50 years, among those whose epilepsy is categorized as structural/metabolic, those whose seizures do not fully remit under treatment, and those with convulsive seizures. Among deaths directly attributable to epilepsy or seizures, important immediate causes include sudden unexpected death in epilepsy (SUDEP), status epilepticus, unintentional injuries, and suicide. Epilepsy-associated premature mortality imposes a significant public health burden, and many of the specific causes of death are potentially preventable. These require increased attention from healthcare providers, researchers, and public health professionals.UpsherSmithCyberonicsDepartment of RehabilitationMount Sinai Medical CenterNew York University Langone Comprehensive Epilepsy CenterNational Institutes of HealthCenters for Disease Control and PreventionEpilepsy Study ConsortiumEpilepsiaWellcome Trust, United KingdomDepartment of Health's NIHR Biomedical Research CentresMarvin Weil Epilepsy Research FundGlaxoSmithKline (GSK)EisaiUCBEuropean UnionDutch Epilepsy FundsWorld Health Organization (WHO)United Kingdom Epilepsy SocietyGlaxoSmithKlineNovartisBialCitizens United for Research in Epilepsy (CURE)Stockholm County CouncilEmory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USAUniv Bari Aldo Moro, Pia Fdn Cardinale G Panico, Dept Clin Res Neurol, Lecce, ItalyUniv Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, ItalyMario Negri Inst Pharmacol Res, Milan, ItalyColumbia Univ, Sergievsky Ctr, New York, NY USAColumbia Univ, Mailman Sch Publ Hlth, New York, NY USAUCL, Inst Child Hlth, Dept Neurosci, London, EnglandMuhimbili Univ Hlth & Allied Sci, Dept Paediat, Dar Es Salaam, TanzaniaUniv Oxford, Dept Psychiat, Oxford, EnglandUniv Fed Sao Paulo, Dept Neurol & Neurosurg, Sao Paulo, BrazilUCL Inst Neurol, NIHR Univ Coll London Hosp, Biomed Res Ctr, London, EnglandEpilepsy Inst Netherlands Fdn SEIN, Heemstede, EnglandKarolinska Inst, Dept Clin Neurosci, Stockholm, SwedenDepartment of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilWeb of Science17-26engWileyEpilepsiaSeizuresConvulsionsDeathDeveloped countriesResource-rich countriesPremature mortalityThe burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHoboken581info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/564492022-02-08 12:09:32.398metadata only accessoai:repositorio.unifesp.br:11600/56449Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:15:17.324961Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy |
title |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy |
spellingShingle |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy Thurman, David J. Seizures Convulsions Death Developed countries Resource-rich countries Premature mortality |
title_short |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy |
title_full |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy |
title_fullStr |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy |
title_full_unstemmed |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy |
title_sort |
The burden of premature mortality of epilepsy in high-income countries: A systematic review from the Mortality Task Force of the International League Against Epilepsy |
author |
Thurman, David J. |
author_facet |
Thurman, David J. Logroscino, Giancarlo Beghi, Ettore Hauser, W. Allen Hesdorffer, Dale C. Newton, Charles R. Scorza, Fulvio Alexandre [UNIFESP] Sander, Josemir W. Tomson, Torbjorn |
author_role |
author |
author2 |
Logroscino, Giancarlo Beghi, Ettore Hauser, W. Allen Hesdorffer, Dale C. Newton, Charles R. Scorza, Fulvio Alexandre [UNIFESP] Sander, Josemir W. Tomson, Torbjorn |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Thurman, David J. Logroscino, Giancarlo Beghi, Ettore Hauser, W. Allen Hesdorffer, Dale C. Newton, Charles R. Scorza, Fulvio Alexandre [UNIFESP] Sander, Josemir W. Tomson, Torbjorn |
dc.subject.eng.fl_str_mv |
Seizures Convulsions Death Developed countries Resource-rich countries Premature mortality |
topic |
Seizures Convulsions Death Developed countries Resource-rich countries Premature mortality |
description |
Since previous reviews of epidemiologic studies of premature mortality among people with epilepsy were completed several years ago, a large body of new evidence about this subject has been published. We aim to update prior reviews of mortality in epilepsy and to reevaluate and quantify the risks, potential risk factors, and causes of these deaths. We systematically searched the Medline and Embase databases to identify published reports describing mortality risks in cohorts and populations of people with epilepsy. We reviewed relevant reports and applied criteria to identify those studies likely to accurately quantify these risks in representative populations. From these we extracted and summarized the reported data. All population-based studies reported an increased risk of premature mortality among people with epilepsy compared to general populations. Standard mortality ratios are especially high among people with epilepsy aged <50 years, among those whose epilepsy is categorized as structural/metabolic, those whose seizures do not fully remit under treatment, and those with convulsive seizures. Among deaths directly attributable to epilepsy or seizures, important immediate causes include sudden unexpected death in epilepsy (SUDEP), status epilepticus, unintentional injuries, and suicide. Epilepsy-associated premature mortality imposes a significant public health burden, and many of the specific causes of death are potentially preventable. These require increased attention from healthcare providers, researchers, and public health professionals. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-31T12:46:54Z |
dc.date.available.fl_str_mv |
2020-07-31T12:46:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Epilepsia. Hoboken, v. 58, n. 1, p. 17-26, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/56449 http://dx.doi.org/10.1111/epi.13604 |
dc.identifier.issn.none.fl_str_mv |
0013-9580 |
dc.identifier.doi.none.fl_str_mv |
10.1111/epi.13604 |
dc.identifier.wos.none.fl_str_mv |
WOS:000393682700005 |
identifier_str_mv |
Epilepsia. Hoboken, v. 58, n. 1, p. 17-26, 2017. 0013-9580 10.1111/epi.13604 WOS:000393682700005 |
url |
https://repositorio.unifesp.br/handle/11600/56449 http://dx.doi.org/10.1111/epi.13604 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Epilepsia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
17-26 |
dc.coverage.none.fl_str_mv |
Hoboken |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
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1783460268155600896 |