Immune development in HIV-exposed uninfected children born to HIV-infected women

Detalhes bibliográficos
Autor(a) principal: Miyamoto, Maristela [UNIFESP]
Data de Publicação: 2017
Outros Autores: Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP], Ono, Erika [UNIFESP], Succi, Regina Célia de Menezes [UNIFESP], Pahwa, Savita, Moraes-Pinto, Maria Isabel de [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/56276
http://dx.doi.org/10.1590/S1678-9946201759030
Resumo: Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 years
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spelling Miyamoto, Maristela [UNIFESP]Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]Ono, Erika [UNIFESP]Succi, Regina Célia de Menezes [UNIFESP]Pahwa, SavitaMoraes-Pinto, Maria Isabel de [UNIFESP]2020-07-31T12:46:33Z2020-07-31T12:46:33Z2017Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.0036-4665https://repositorio.unifesp.br/handle/11600/56276http://dx.doi.org/10.1590/S1678-9946201759030S0036-46652017005000217.pdfS0036-4665201700500021710.1590/S1678-9946201759030WOS:000403274300006Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 yearsfor plasma sCD14, IL-2, IL-6, IL-7, IL-10, IL-12p70, IL-13, IL-17, IFN-gamma, TNF-alpha, G-CSF, GM-CSF and MCP-1, which increased from birth to 12 months and then decreased at 6-12 yearsand for TREC/10(6) PBMC at birth in HEU and controls. By contrast, plasma MIP-1 beta levels were lower in HEU than in controls (p=0.009) at 12 months, and IL-4 levels were higher in HEU than controls (p=0.04) at 6-12 years. Immune activation was higher in HEU at 12 months and at 6-12 years than controls based on frequencies of CD38+HLA-DR+CD8+T cells (p=0.05) and of CD38+HLA-DR+CD4+T cells (p=0.006). Resting memory and activated mature B cells increased from birth to 6-12 years in both groups. The development of the immune system in vertically HEU individuals is comparable to the general population in most parameters, but subtle or transient differences exist. Their role in influencing clinical incidences in HEU is unknown.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, BrazilUniv Miami, Dept Med, Miami, FL USAUniversidade Federal de São Paulo, Departamento de Pediatria, Divisão de Infectologia Pediátrica, Rua Pedro de Toledo, 781, 9º andar, CEP 04039-032, Vila Clementino, São Paulo, SP, Brazil.FAPESP: 10/09701-3FAPESP: 10/09738-4Web of Science-engInst Medicina Tropical Sao PauloRevista Do Instituto De Medicina Tropical De Sao PauloHIV-exposed uninfectedLymphocyte activationCytokinesLipopolysaccharideCD14 antigenImmune development in HIV-exposed uninfected children born to HIV-infected womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo59info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0036-46652017005000217.pdfapplication/pdf380985${dspace.ui.url}/bitstream/11600/56276/1/S0036-46652017005000217.pdfce1f2369a4e344e6de788695faa52473MD51open accessTEXTS0036-46652017005000217.pdf.txtS0036-46652017005000217.pdf.txtExtracted texttext/plain36603${dspace.ui.url}/bitstream/11600/56276/2/S0036-46652017005000217.pdf.txt0087d8cb15e0fbd87dbd9e95fbcd7073MD52open accessTHUMBNAILS0036-46652017005000217.pdf.jpgS0036-46652017005000217.pdf.jpgIM Thumbnailimage/jpeg6918${dspace.ui.url}/bitstream/11600/56276/4/S0036-46652017005000217.pdf.jpg2f1e23a6320e301417c005f8d2e0afe3MD54open access11600/562762022-08-01 00:40:57.679open accessoai:repositorio.unifesp.br:11600/56276Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:08:00.572817Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Immune development in HIV-exposed uninfected children born to HIV-infected women
title Immune development in HIV-exposed uninfected children born to HIV-infected women
spellingShingle Immune development in HIV-exposed uninfected children born to HIV-infected women
Miyamoto, Maristela [UNIFESP]
HIV-exposed uninfected
Lymphocyte activation
Cytokines
Lipopolysaccharide
CD14 antigen
title_short Immune development in HIV-exposed uninfected children born to HIV-infected women
title_full Immune development in HIV-exposed uninfected children born to HIV-infected women
title_fullStr Immune development in HIV-exposed uninfected children born to HIV-infected women
title_full_unstemmed Immune development in HIV-exposed uninfected children born to HIV-infected women
title_sort Immune development in HIV-exposed uninfected children born to HIV-infected women
author Miyamoto, Maristela [UNIFESP]
author_facet Miyamoto, Maristela [UNIFESP]
Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
Ono, Erika [UNIFESP]
Succi, Regina Célia de Menezes [UNIFESP]
Pahwa, Savita
Moraes-Pinto, Maria Isabel de [UNIFESP]
author_role author
author2 Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
Ono, Erika [UNIFESP]
Succi, Regina Célia de Menezes [UNIFESP]
Pahwa, Savita
Moraes-Pinto, Maria Isabel de [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Miyamoto, Maristela [UNIFESP]
Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]
Ono, Erika [UNIFESP]
Succi, Regina Célia de Menezes [UNIFESP]
Pahwa, Savita
Moraes-Pinto, Maria Isabel de [UNIFESP]
dc.subject.eng.fl_str_mv HIV-exposed uninfected
Lymphocyte activation
Cytokines
Lipopolysaccharide
CD14 antigen
topic HIV-exposed uninfected
Lymphocyte activation
Cytokines
Lipopolysaccharide
CD14 antigen
description Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 years
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2020-07-31T12:46:33Z
dc.date.available.fl_str_mv 2020-07-31T12:46:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.citation.fl_str_mv Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/56276
http://dx.doi.org/10.1590/S1678-9946201759030
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dc.identifier.file.none.fl_str_mv S0036-46652017005000217.pdf
dc.identifier.scielo.none.fl_str_mv S0036-46652017005000217
dc.identifier.doi.none.fl_str_mv 10.1590/S1678-9946201759030
dc.identifier.wos.none.fl_str_mv WOS:000403274300006
identifier_str_mv Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.
0036-4665
S0036-46652017005000217.pdf
S0036-46652017005000217
10.1590/S1678-9946201759030
WOS:000403274300006
url https://repositorio.unifesp.br/handle/11600/56276
http://dx.doi.org/10.1590/S1678-9946201759030
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Revista Do Instituto De Medicina Tropical De Sao Paulo
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dc.coverage.none.fl_str_mv Sao Paulo
dc.publisher.none.fl_str_mv Inst Medicina Tropical Sao Paulo
publisher.none.fl_str_mv Inst Medicina Tropical Sao Paulo
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
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