Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-Infected individuals from Botswana and Cameroon

• Autor(a) principal: Gupta, S. B.
• Data de Publicação: 2006
• Outros Autores: Mast, C. T., Wolfe, N. D., Novitsky, V, Dubey, S. A., Kallas, Esper Georges [UNIFESP], Schechter, M., Mbewe, B., Vardas, E., Pitisuttithum, P., Burke, D., Freed, D., Mogg, R., Coplan, P. M., Condra, J. H., Long, R. S., Anderson, K., Casimiro, D. R., Shiver, J. W., Straus, W. L.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/28921; http://dx.doi.org/10.1097/01.qai.0000223017.01568.e7
• topic: HIV; cell-mediated immunity; viral clade

An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples.