Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune
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| Data de Publicação: | 2018 |
| Tipo de documento: | Dissertação |
| Idioma: | por |
| Título da fonte: | Biblioteca Digital de Teses e Dissertações da UFTM |
| Texto Completo: | http://bdtd.uftm.edu.br/handle/tede/655 |
Resumo: | Introdução: A deficiência de calcitonina foi reportada na tireoidite crônica autoimune (TCA). O desequilíbrio da secreção e ação dos hormônios envolvidos na homeostase e metabolismo do cálcio e fósforo, incluindo a calcitonina, presumivelmente podem alterar as concentrações dos componentes minerais ósseos, a ação acoplada dos osteoblastos e osteoclastos que atuam nos processos de remodelação óssea, levando a alterações da massa óssea, resultando em osteopenia/osteoporose. Objetivo: investigar alterações da massa óssea em mulheres com TCA, e presumivelmente deficientes em calcitonina. Métodos: Selecionamos 45 mulheres pré- menopausadas com TCA assistidas no ambulatório de tireoide. Destas, 33 realizaram exames bioquímicos e hormonais para excluir comorbidades, avaliar metabolismo ósseo e densitometria óssea (DXA, aparelho Lunar DPX GE Prodigy); 26 atenderam aos critérios de inclusão sendo comparadas a 26 mulheres saudáveis (grupo GC) pareadas por idade e índice de massa corpórea (IMC). A análise estatística foi realizada utilizando o programa SPSS. Como todas as variáveis apresentaram normalidade, para comparações foi empregado teste t de Student e teste do Qui-quadrado e, para as correlações, teste de Pearson, com significância se p<0,05. Resultados: Idade variou de 30;0 a 45;6 anos;meses (mediana TCA 37;11 e GC 35;3) e IMC foi 25,8 ± 6,3 no TCA e 27,5 ± 5,6Kg/m² no GC. Função tireoidiana mostrou-se adequada e as concentrações de cálcio, fósforo, magnésio, paratormônio, vitamina D foram normais em ambos os grupos. A densidade mineral óssea nas áreas padronizadas da coluna e fêmur foi normal e não apresentou diferença entre ambos, correlacionando-se positivamente apenas com IMC. Conclusão: Não se observou alteração de massa óssea na TCA comparada a pacientes saudáveis. A presumida deficiência de calcitonina inerente a esta condição clínica não resulta em osteopenia /osteoporose desde que outros fatores envolvidos na manutenção de massa óssea estejam adequados. |
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Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimuneTireoidite Autoimune.Calcitonina.Densidade Óssea.Osteoporose.Thyroiditis Autoimmune.Calcitonin.Bone Density.Osteoporosis.EndocrinologiaIntrodução: A deficiência de calcitonina foi reportada na tireoidite crônica autoimune (TCA). O desequilíbrio da secreção e ação dos hormônios envolvidos na homeostase e metabolismo do cálcio e fósforo, incluindo a calcitonina, presumivelmente podem alterar as concentrações dos componentes minerais ósseos, a ação acoplada dos osteoblastos e osteoclastos que atuam nos processos de remodelação óssea, levando a alterações da massa óssea, resultando em osteopenia/osteoporose. Objetivo: investigar alterações da massa óssea em mulheres com TCA, e presumivelmente deficientes em calcitonina. Métodos: Selecionamos 45 mulheres pré- menopausadas com TCA assistidas no ambulatório de tireoide. Destas, 33 realizaram exames bioquímicos e hormonais para excluir comorbidades, avaliar metabolismo ósseo e densitometria óssea (DXA, aparelho Lunar DPX GE Prodigy); 26 atenderam aos critérios de inclusão sendo comparadas a 26 mulheres saudáveis (grupo GC) pareadas por idade e índice de massa corpórea (IMC). A análise estatística foi realizada utilizando o programa SPSS. Como todas as variáveis apresentaram normalidade, para comparações foi empregado teste t de Student e teste do Qui-quadrado e, para as correlações, teste de Pearson, com significância se p<0,05. Resultados: Idade variou de 30;0 a 45;6 anos;meses (mediana TCA 37;11 e GC 35;3) e IMC foi 25,8 ± 6,3 no TCA e 27,5 ± 5,6Kg/m² no GC. Função tireoidiana mostrou-se adequada e as concentrações de cálcio, fósforo, magnésio, paratormônio, vitamina D foram normais em ambos os grupos. A densidade mineral óssea nas áreas padronizadas da coluna e fêmur foi normal e não apresentou diferença entre ambos, correlacionando-se positivamente apenas com IMC. Conclusão: Não se observou alteração de massa óssea na TCA comparada a pacientes saudáveis. A presumida deficiência de calcitonina inerente a esta condição clínica não resulta em osteopenia /osteoporose desde que outros fatores envolvidos na manutenção de massa óssea estejam adequados.Introduction: Calcitonin deficiency has been reported in chronic autoimmune thyroiditis (ACT). The imbalance of secretion and action of the hormones involved in homeostasis of calcium and phosphorus metabolism, including calcitonin, may alter the concentrations of bone mineral components, the coupled action of osteoblasts and osteoclasts that act on the processes of bone remodeling, leading to changes in bone mass, resulting in osteopenia / osteoporosis. Objective: to investigate changes in bone mass in women with ACT, presumably deficient in calcitonin. Methods: We selected 45 premenopausal women with ACT assisted in the thyroid outpatient clinic. Of these, 33 performed biochemical and hormonal exams to exclude comorbidities, to evaluate bone metabolism and densitometry (DXA, Lunar DPX GE Prodigy apparatus); 26 met the inclusion criteria compared to 26 healthy women (CG group) matched for age and body mass index (BMI). Statistical analysis was performed using the SPSS program. As all variables presented normality, for comparisons we used Student's t-test and Chi-square test and for the correlations Pearson test, with significance being p <0.05. Results: Age varied from 30.0 to 45.6 years.months (median ACT 37.11 and CG 35.3) and BMI was 25.8 ± 6.3 and 27.5 ± 5.6 kg/m² in ACT and CG respectively. Thyroid function proved to be adequate and calcium, phosphorus, magnesium, parathormone and vitamin D concentrations were normal in both groups. The bone mineral density in the standard areas of the spine and femur was normal and showed no difference between the two groups, correlating positively only with BMI. Conclusion: There was no alteration of bone mass in the ACT compared to healthy patients. The presumed deficiency of calcitonin inherent to this clinical condition does not result in osteopenia / osteoporosis.Universidade Federal do Triângulo MineiroInstituto de Ciências da Saúde - ICS::Programa de Pós-Graduação em Ciências da SaúdeBrasilUFTMPrograma de Pós-Graduação em Ciências da SaúdeBORGES, Maria de Fátima25537032600http://lattes.cnpq.br/3192369967083138FRANCISCON, Priscila de Melo2019-05-20T13:47:21Z2018-08-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfFRANCISCON, Priscila de Melo. 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The Journal of Clinical Endocrinology and Metabolism, v. 92, n. 5, p. 1640-1646, May 2007.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da UFTMinstname:Universidade Federal do Triangulo Mineiro (UFTM)instacron:UFTM2019-05-21T04:00:30Zoai:bdtd.uftm.edu.br:tede/655Biblioteca Digital de Teses e Dissertaçõeshttp://bdtd.uftm.edu.br/PUBhttp://bdtd.uftm.edu.br/oai/requestbdtd@uftm.edu.br||bdtd@uftm.edu.bropendoar:2019-05-21T04:00:30Biblioteca Digital de Teses e Dissertações da UFTM - Universidade Federal do Triangulo Mineiro (UFTM)false |
| dc.title.none.fl_str_mv |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune |
| title |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune |
| spellingShingle |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune FRANCISCON, Priscila de Melo Tireoidite Autoimune. Calcitonina. Densidade Óssea. Osteoporose. Thyroiditis Autoimmune. Calcitonin. Bone Density. Osteoporosis. Endocrinologia |
| title_short |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune |
| title_full |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune |
| title_fullStr |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune |
| title_full_unstemmed |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune |
| title_sort |
Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune |
| author |
FRANCISCON, Priscila de Melo |
| author_facet |
FRANCISCON, Priscila de Melo |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
BORGES, Maria de Fátima 25537032600 http://lattes.cnpq.br/3192369967083138 |
| dc.contributor.author.fl_str_mv |
FRANCISCON, Priscila de Melo |
| dc.subject.por.fl_str_mv |
Tireoidite Autoimune. Calcitonina. Densidade Óssea. Osteoporose. Thyroiditis Autoimmune. Calcitonin. Bone Density. Osteoporosis. Endocrinologia |
| topic |
Tireoidite Autoimune. Calcitonina. Densidade Óssea. Osteoporose. Thyroiditis Autoimmune. Calcitonin. Bone Density. Osteoporosis. Endocrinologia |
| description |
Introdução: A deficiência de calcitonina foi reportada na tireoidite crônica autoimune (TCA). O desequilíbrio da secreção e ação dos hormônios envolvidos na homeostase e metabolismo do cálcio e fósforo, incluindo a calcitonina, presumivelmente podem alterar as concentrações dos componentes minerais ósseos, a ação acoplada dos osteoblastos e osteoclastos que atuam nos processos de remodelação óssea, levando a alterações da massa óssea, resultando em osteopenia/osteoporose. Objetivo: investigar alterações da massa óssea em mulheres com TCA, e presumivelmente deficientes em calcitonina. Métodos: Selecionamos 45 mulheres pré- menopausadas com TCA assistidas no ambulatório de tireoide. Destas, 33 realizaram exames bioquímicos e hormonais para excluir comorbidades, avaliar metabolismo ósseo e densitometria óssea (DXA, aparelho Lunar DPX GE Prodigy); 26 atenderam aos critérios de inclusão sendo comparadas a 26 mulheres saudáveis (grupo GC) pareadas por idade e índice de massa corpórea (IMC). A análise estatística foi realizada utilizando o programa SPSS. Como todas as variáveis apresentaram normalidade, para comparações foi empregado teste t de Student e teste do Qui-quadrado e, para as correlações, teste de Pearson, com significância se p<0,05. Resultados: Idade variou de 30;0 a 45;6 anos;meses (mediana TCA 37;11 e GC 35;3) e IMC foi 25,8 ± 6,3 no TCA e 27,5 ± 5,6Kg/m² no GC. Função tireoidiana mostrou-se adequada e as concentrações de cálcio, fósforo, magnésio, paratormônio, vitamina D foram normais em ambos os grupos. A densidade mineral óssea nas áreas padronizadas da coluna e fêmur foi normal e não apresentou diferença entre ambos, correlacionando-se positivamente apenas com IMC. Conclusão: Não se observou alteração de massa óssea na TCA comparada a pacientes saudáveis. A presumida deficiência de calcitonina inerente a esta condição clínica não resulta em osteopenia /osteoporose desde que outros fatores envolvidos na manutenção de massa óssea estejam adequados. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-08-29 2019-05-20T13:47:21Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
| format |
masterThesis |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
FRANCISCON, Priscila de Melo. Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune. 2018. 120f. Dissertação (Mestrado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2018. http://bdtd.uftm.edu.br/handle/tede/655 |
| identifier_str_mv |
FRANCISCON, Priscila de Melo. Avaliação da densidade mineral óssea em mulheres pré-menopausadas com tireoidite crônica autoimune. 2018. 120f. Dissertação (Mestrado em Ciências da Saúde) - Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Triângulo Mineiro, Uberaba, 2018. |
| url |
http://bdtd.uftm.edu.br/handle/tede/655 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.none.fl_str_mv |
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